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| 1 | MOCVD与MBE生长GaAs/AlGaAs量子阱材料的红外探测器特性比较显示文摘用金属有机物化学气相沉积法 ( MOCVD)生长 Ga As/Al Ga As量子阱材料 ,并制成红外探测器 .测量了材料的光致发光光谱和探测器的光电流响应光谱及其它光电特性 ,峰值波长7.9μm,响应率达到 6× 1 0 3V/W,与分子束外延法 ( MBE)生长的材料和相关器件进行了比较 ,MOCVD法可满足量子阱材料和器件的要求 . | 李娜 李宁 陆卫 窦红飞 陈张海 刘兴权 沈学础 H.H.Tan LanFu C.Jagadish M.B.Johnston M.Gal | 2000 | Journal of Semiconductors2000，21，5： | 5 |
| 2 | Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion显示文摘Glioblastoma (GBM ) 是在成年人的最流行的恶意的主要大脑肿瘤并且展出异常地好攻击的显型的一个系列。肿瘤房间增长和侵略被 chemokines 和他们的受体极其调整。最近的研究证明了 chemokine CCL5 和它的受体 CCR5 在肿瘤侵略和转移起重要作用。尽管如此,在 GBM 的 CCR5 的角色仍然保持不清楚。现在的学习提供 chemokine 受体 CCR5 高度被表示并且在人的 GBM 把预后与穷人联系了的证据。机械学地, CCL5CCR5 调停 Akt 的激活,并且随后在 U87 和 U251 房间导致增长和侵略回答。而且, CCR5 的下面规定显著地在 U87 肿瘤禁止了 glioma 的生长异种皮移植老鼠模型。最后,在 GBM 的高 CCR5 表示在耐心的样品与增加的 p-Akt 表示被相关。一起,这些调查结果建议 CCR5 是与 gliomagenesis 联系的一个批评分子的事件。 | Lanfu Zhao Yuan Wang Yafei Xue Wenhai Lv Yufu Zhang Shiming He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 3 | Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study显示文摘Objective:This study aimed at examining the alterations in metabolomic profiles caused by treatment of H.pylori infection,and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up after treatment.Methods:An intervention trial was performed in 183 participants,117 of whom were H.pylori positive participants receiving treatment for H.pylori infection.H.pylori positive participants were prospectively followed for 182 to 1,289 days.Untargeted metabolomics assays were conducted on plasma samples collected at baseline,6 months after treatment,and during continued follow-up.Results:We identified 59 metabolites with differential posttreatment changes between participants with successful and failed H.pylori eradication,17 metabolites significantly distinguished participants with successful vs.failed eradication.Two metabolites[PC(18:1(11Z)/14:1(9Z))and(2S)-6-amino-2-formamidohexanamide]showed posttreatment changes positively associated with successful H.pylori eradication,and were inversely associated with the risk of gastric lesion progression among participants with successful eradication.In contrast,9-decenoic acid showed posttreatment changes inversely associated with successful eradication:its level was positively associated with the risk of gastric lesion progression among participants with successful eradication.Although the identified metabolites showed a temporary but significant decline after treatment,the trend generally reversed during continued follow-up,and pretreatment levels were restored.Conclusions:Treatment of H.pylori infection significantly altered plasma metabolic profiles in the short term,and key metabolites were capable of distinguishing participants with successful vs.failed eradication,but might not substantially affect metabolic regulation in the long term.Several plasma metabolites were differentially associated with the risk of gastric lesion progression among participants with successful or failed eradication. | Wenhui Wu Zongchao Liu Zhexuan Li Weidong Liu Lanfu Zhang Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
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