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| 1 | Gut epithelial barrier dysfunction in humanimmunodeficiency virus-hepatitis C virus coinfectedpatients:Influence on innate and acquired immunity显示文摘Even in cases where viral replication has been controlled by antiretroviral therapy for long periods of time, human immunodeficiency virus(HIV)-infected patients have several non-acquired immunodeficiency syndrome(AIDS) related co-morbidities, including liver disease, cardiovascular disease and neurocognitive decline, which have a clear impact on survival. It has been considered that persistent innate and acquired immune activation contributes to the pathogenesis of these non-AIDS related diseases. Immune activation has been related with several conditions, remarkably with the bacterial translocation related with the intestinal barrier damage by the HIV or by hepatitis C virus(HCV)-related liver cirrhosis. Consequently, increased morbidity and mortality must be expected in HIV-HCV coinfected patients. Disrupted gut barrier lead to an increased passage of microbial products and to an activation of the mucosal immune system and secretion of inflammatory mediators, which in turn might increase barrier dysfunction. In the present review, the intestinal barrier structure, measures of intestinal barrier dysfunction and the modifications of them in HIV monoinfection and in HIV-HCV coinfection will be considered. Both pathogenesis and the consequences for the progression of liver disease secondary to gut microbial fragment leakage and immune activation will be assessed. | Mercedes Márquez Clotilde Fernández Gutiérrez delÁlamo JoséAntonio Girón-González | 2016 | World Journal of Gastroenterology2016，22，4： | 7 |
| 2 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 3 | Multi residue determination of the penicillins regulated bythe European Union,in bovine,porcine and chicken muscle,by LC-MS/MS显示文摘 | MACAROV C A TONG L Martínez-Huélamo M | 2012 | Food Chem2012，135，4： | 1 |
| 4 | Reduction of counts of Listeria monocytogenes in cheese by means of high hydrostatic pressure 显示文摘 | Lopez-Pedemonte T Roig-Sagues A De Lamo S | 2007 | Food Microbiology2007，24，1： | 1 |
| 5 | Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria 显示文摘 | De Lamo Marin S Xu Y Meijler M | 2007 | Bioorganic & Medicinal Chemistry Etters2007，17，6： | 1 |
| 6 | Rapid detection and differentiation of Alicyclobacillus species in fruit juice using hydrophobic grid membranes and attenuated total reflectance infrared microspectroscopy 显示文摘 | GRASSO E M YOUSEF A E DE LAMO CASTELLVI S | 2009 | Journal of Agricultural and Food Chemistry2009，57，10： | 1 |
| 7 | A review of the efficacy and safety of oral antidiabetic drugs显示文摘 | Stein SA Lamos EM Davis SN | 2013 | Expert Opin Drug Saf2013，12，2： | 1 |
| 8 | Canagliflozin, an inhibitor of sodium-glucose cotransporter 2, for the treatment of type 2 diabetes mellitus 显示文摘 | LAMOS EM YOUNK LM DAVIS SN | 2013 | Expert Opin Drug Metab Toxicol2013，9，6： | 1 |
| 9 | Changes in exercise tolerance,health related quality of life,and peripheral muscle characteristics of chronic obstructive pulmonary disease patients after 6 weeks' training显示文摘 | Montes de Oca M Torres SH González Y Romero E Hernández N Tálamo C | 2005 | Arch Bronconeumol2005，41，8： | 1 |
| 10 | Canagliflozin , an inhibitor of so- dium-glucose cotransporter 2, for the treatment of type 2 diabetes mel- litus显示文摘 | Lamos EM Younk LM Davis SN | 2013 | Expert Opin Drug Metab Toxicol2013，9，6： | 1 |
| 11 | A review of the effica- cy and safety of oral antidiabetic drugs显示文摘 | Stein SA Lamos EM Davis SN | 2013 | Expert Opin Dr- ugSaf2013，12，2： | 1 |
| 12 | Reduction of counts of Listeria monocytogenes in cheese by means of high hydrostatic pressure显示文摘 | López-Pedemonte T Roig-Sagués A de Lamo S | 2007 | Food Microbiolog2007，24，1： | 1 |
| 13 | Multi residuedetermination of the penicillins regulated by the European Union,in bovine,porcine and chicken muscle, by LC - MS/MS 显示文摘 | Macarov C A Tong L Martfnez-Hu^lamo M | 2012 | Food Chemistry2012，135，4： | 1 |
| 14 | Reduction of counts of Listeria monocy togenes in cheese by means of high hydrostatic pressure显示文摘 | López-Pedemonte T Roig-Sagués A de Lamo S | 2007 | Food Microbiology2007，24，1： | 1 |
| 15 | 18 F-FDG PET/CT in the evaluation of POEMS syndrome显示文摘 | Albertí MA Martinez-Yélamos S Fernandez A | 2010 | Eur J Radiol2010，76，： | 1 |
| 16 | An evaluation of bone mineral densi-ty in Australian women of Asian descent显示文摘 | Lamos G Baillon LG | 1998 | AustralasRadiol1998，42，： | 1 |
| 17 | Changes in Exercise Tolerance, Health Related Quality of Life, and Peripheral Muscle Characteristics of Chronic Obstructive Pulmonary Disease Patients After 6 Weeks’ Training显示文摘 | M. Montes de Oca S.H. Torres Y. González E. Romero N. Hernández C. Tálamo | 2005 | Archivos de Bronconeumología (Internet)2005，，8： | 1 |
| 18 | Role of leptin in Japanese quail development显示文摘 | Máǔajová M Lamoéová D Zeman M | 2002 | Acta Veterinaria Brno2002，71，： | 1 |
| 19 | A review of the efficacy and safety of oral antidiabetic drugs显示文摘 | Stein SA Lamos EM Davis SN | 2013 | Expert Opin Drug Saf2013，12，2： | 1 |
| 20 | Ethylene seems required for the berry de- velopment and ripening in grape, a non-climacteric fruit显示文摘 | CHERVIN C EL-KEREAMY A ROUSTAN J P LATCHE A LAMO J BOUZAYEN M | 2004 | Plant Sci- ence2004，167，6： | 1 |
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