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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | randomized trial of neoadjuvant cisplatin,vincristine,bleomyin,and radical hysterectomy versus radiation therapy for bulky stage I B and II A cervical cancer 显示文摘 | Chang TC Lai CH Hong JH | 2000 | Chn Oncol2000，18，8： | 1 |
| 3 | Laparoscopic approach of surgical treatment for primary hepatolithiasis:a cohort study显示文摘 | Lai EC Ngai TC Yang GP | | 0，，05： | 1 |
| 4 | Randomized clinical trial of Ligasure versus conventional surgery for extended gastric cancer resection显示文摘 | Chen TC Lai IR | 2003 | Br J Surg2003，90，12： | 1 |
| 5 | Laparoseopic approach of sur- gical treatment for primary hepatolithiasis: a cohort study 显示文摘 | Lai EC Ngai TC Yang GP | 2010 | Am J Surg2010，199，5： | 1 |
| 6 | Clinieopathologie features and prognostic analysis of MSI-high colon eaneer显示文摘 | Lin CC Lai YL Lin TC | 2012 | Int J Coloreetal Dis2012，，3： | 1 |
| 7 | Prognostic factors in surgically treated small cell cervical carcinoma followed by adjuvant chemotherapy 显示文摘 | Chang TC Lai CH Tseng CJ | 1998 | Cancer1998，83，4： | 1 |
| 8 | 18F-FDG uptake in squamous cell carcinoma of the cervix is correlated with glucose transporter 1 expression显示文摘 | Yen TC See LC Lai CH et al | 2004 | J Nucl Med2004，45，0： | 1 |
| 9 | prognostic factors in surgically treated small cell cervical carcinoma followed by adjuvant chemotherapy显示文摘 | Chang TC Lai CH Tseng CJ | 1998 | Cancer1998，83，4： | 1 |
| 10 | Enterovirus 71 trigging of neuronal apoptosis through activation of Abl-Cdk5 Signalling 显示文摘 | Chen TC Lai YK Yu CK | 2007 | Cell Mierobiol2007，9，11： | 1 |
| 11 | MicroRNA-122,a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma显示文摘 | Tsai WC Hsu PW Lai TC | 2009 | Hepatology2009，49，5： | 1 |
| 12 | Outcome and prognostic factors in ovarian germ cell malignancies显示文摘 | Lai CH Chang TC Hsueh S | 2005 | Gynecol Oncol2005，96，78： | 1 |
| 13 | Association of asthma and bipolar disorder:A nationwide population-based study in Taiwan显示文摘 | Lin TC Lee CT Lai TJ | 2014 | J Affect Disord2014，2，168： | 1 |
| 14 | A prospective randomized trial to study the impact of pretreatment FDG-PET for cervical cancer patients with MRI-detected positive pelvic but negative para-aortic lymphadenopathy 显示文摘 | Tsai CS Lai CH Chang TC | 2010 | IntJ Radiat Oncol Biol Phys2010，76，2： | 1 |
| 15 | 18 F-FDG uptake in squamous cell carcinoma of the cervix is correlated with glucose transporter 1 expression显示文摘 | Yen TC See LC Lai CH | | 0，，： | 1 |
| 16 | Hypoxia-responsive miR- NAs target argonaute 1 to promote angiogenesis显示文摘 | CHEN Z LAI TC JAN YH | 2013 | J Clin In-vest2013，123，3： | 1 |
| 17 | Discovery,regulation,and action of the major apoptotic nucleases DFF40/CAD and endonuclease G显示文摘 | Cheng AC Huang TC Lai CS | 2005 | J Cell Biochem2005，94，6： | 1 |
| 18 | Prognostic factors in patients with bulky stage ⅠB or ⅡA cervical carcinoma undergoing neoadjurant chemotherapy and radical hysterectomy 显示文摘 | Lai CH Hsueh S Chang TC | 1997 | Gynecol Oncol1997，64，3： | 1 |
| 19 | Prognostic factors insurgically treated small cell cervical carcinoma followed byadjuvant chemotherapy显示文摘 | Chang TC Lai CH Tseng CJ | 1998 | Cancer1998，83，： | 1 |
| 20 | Positron emission tomography in gynecologic cancer 显示文摘 | Yen TC Lai CH | 2006 | Semin Nucl Med2006，36，1： | 1 |
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