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164篇 您的检索式：作者名="Laffitte"

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	题名	作者	年代	出处	被引量
1	Fabrication of sharp silicon hollow microneedles by deep-reactive ion etching towards minimally invasive diagnostics显示文摘Microneedle technologies have the potential for expanding the capabilities of wearable health monitoring from physiology to biochemistry.This paper presents the fabrication of silicon hollow microneedles by a deep-reactive ion etching(DRIE)process,with the aim of exploring the feasibility of microneedle-based in-vivo monitoring of biomarkers in skin fluid.Such devices shall have the ability to allow the sensing elements to be integrated either within the needle borehole or on the backside of the device,relying on capillary filling of the borehole with dermal interstitial fluid(ISF)for transporting clinically relevant biomarkers to the sensor sites.The modified DRIE process was utilized for the anisotropic etching of circular holes with diameters as small as 30μm to a depth of>300μm by enhancing ion bombardment to efficiently remove the fluorocarbon passivation polymer.Afterward,isotropic wet and/or dry etching was utilized to sharpen the needle due to faster etching at the pillar top,achieving tip radii as small as 5μm.Such sharp microneedles have been demonstrated to be sufficiently robust to penetrate porcine skin without needing any aids such as an impact-insertion applicator,with the needles remaining mechanically intact after repetitive penetrations.The capillary filling of DRIE-etched through-wafer holes with water has also been demonstrated,showing the feasibility of use to transport the analyte to the target sites.	Yan Li Hang Zhang Ruifeng Yang Yohan Laffitte Ulises Schmill Wenhan Hu Moufeed Kaddoura Eric J.M.Blondeel Bo Cui	2019	Microsystems & Nanoengineering2019，5，1：	4
2	Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘	Castrillo A Laffitte BA	2003	Nat Med2003，9，2：	1
3	LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes 显示文摘	Laffitte BA Repa JJ Joseph SB	2001	Proc Natl Acad Sci USA2001，98，2：	1
4	Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue显示文摘	Laffitte BA Chao LC Li J		0，，：	1
5	Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha显示文摘	Venkateswaran A Laffitte BA Joseph SB	2000	Proc Natl Acad Sci USA2000，97，12：	1
6	The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions 显示文摘	Laffitte BA Joseph SB Chen M	2003	Mol Cell Biol2003，23，6：	1
7	Autoregu- lation of the human liver X receptor alpha promoter 显示文摘	Laffitte B A Joseph S B Walczak R	2001	Mol Cell Biol2001，21，：	1
8	Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors显示文摘	Joseph SB Laffitte BA Patel PH	2002	J Biol Chem2002，277，11：	1
9	Severe pustular eruption associated with imatinib and voriconazole in a patient with chronic myeloid leukemia显示文摘	Gambillara E Laffitte E Widmer N	2005	Dermatology2005，211，4：	1
10	Gliotoxin from Aspergillus fumigatus affects phagocytosis and the organization of the actin cytoskeleton by distinct signalling pathways in human neutrophils显示文摘	Comera C Andre K Laffitte J	2007	Microbes Infect2007，9，1：	1
11	Reciprocal regula- tion of inflammation and lipid metabolism by liver X recep- tors 显示文摘	Joseph SB Castrillo A Laffitte BA	2003	Nat Med2003，9，2：	1
12	Dual anaerobic co-digestion of sewage and confectionery waste显示文摘	Laffitte Trouque S Foster C F	2000	Bioresource Technology2000，71，：	1
13	Reciprocal regulation of inflammation and lipid metabolism by liver X receptors 显示文摘	Joseph SB Castrillo A Laffitte BA	2003	Nature Medicine2003，9，2：	1
14	Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘	Joseph SB Castrillo A Laffitte BA	2003	Nature Medicine2003，9，2：	1
15	Transcription of thevascular endothelial growth factor gene in macrophages is regulatedby liver X receptors 显示文摘	Walczak H Joseph SB Laffitte BA	2004	J Biol Chem2004，279，：	1
16	Reciprocal regulation of inflammation and lipid metabolism by liver X receptors显示文摘	Joseph SB Castrillo A Laffitte BA	2003	Nat Med2003，9，2：	1
17	Subclinical doses of T-2 toxin impair acquired immune re- sponse and liver cytoehrome P450 in pigs 显示文摘	MEISSONNIER G M LAFFITTE J RAYMOND I	2008	Toxicology2008，247，1：	1
18	Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue显示文摘	LAFFITTE B A CHAO L C LI J	2003	Proceedings of the National Academy Sciences of United States of America2003，100，：	1
19	Subclinical doses of T-2 toxin impair acquired immune response and liver cytochreme P450 in pigs显示文摘	Meissonnier GM Laffitte J Raymond I	2008	Toxicology2008，247，：	1
20	Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors显示文摘	JOSEPH S B LAFFITTE B A PATEL P H	2002	The Journal of Biological Chemistry2002，277，11：	1

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