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| 1 | PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer显示文摘Background:Programmed cell death ligand-1(PD-L1)and ligand-2(PD-L2)interaction with programmed cell death protein-1(PD-1)represent an immune-inhibiting checkpoint mediating immune evasion and is,accordingly,an important target for blockade-based immunotherapy in cancer.In non-small-cell lung cancer(NSCLC),improved understanding of PD-1 checkpoint blockade-responsive biology and identification of biomarkers for prediction of a clinical response to immunotherapy is warranted.Thus,in the present study,we systematically described PD-L1 and PD-L2 expression correlated genes in NSCLC.Methods:We performed comparative retrospective analyses to identify PD-L1 and PD-L2 mRNA expression corre-lated genes in NSCLC.For this,we examined available datasets from the cancer cell line encyclopedia(CCLE)project lung non-small-cell(Lung_NSC)and the cancer genome atlas(TCGA)projects lung adenocarcinoma(LUAD)and squamous cell carcinoma(LUSC).Results:Analysis of the CCLE dataset Lung_NSC identified expression correlation between PD-L1 and PD-L2.Moreo-ver,we identified expression correlation between 489 genes and PD-L1,191 genes and PD-L2,and 111 genes for both.PD-L1 and PD-L2 also expression correlated in TCGA datasets LUAD and LUSC.In LUAD,we identified expression corre-lation between 257 genes and PD-L1,914 genes and PD-L2,and 211 genes for both.In LUSC,we identified expression correlation between 26 genes and PD-L1,326 genes and PD-L2,and 13 genes for both.Only a few genes expression correlated with PD-L1 and PD-L2 across the CCLE and TCGA datasets.Expression of Interferon signaling-involved genes converged in particular with the expression correlated genes for PD-L1 in Lung_NSC,for PD-L2 in LUSC,and for both PD-L1 and PD-L2 in LUAD.In LUSC,PD-L1,and to a lesser extent PD-L2,expression correlated with chromosome 9p24 localized genes,indicating a chromosome 9p24 topologically associated domain as an important driver of in particu-lar LUSC PD-L1 expression.Expression correlation analyses of the PD-L1 and PD-L2 receptors programmed cell death protein-1(PD-1),Cluster of differentiation 80(CD80),and Repulsive guidance molecule B(RGMB)showed that PD-1 and CD80 expression correlated with both PD-L1 and PD-L2 in LUAD.CD80 expression correlated with PD-L2 in LUSC.Conclusions:We present gene signatures associated with PD-L1 and PD-L2 mRNA expression in NSCLC which could possess importance in relation to understand PD-1 checkpoint blockade-responsive biology and development of gene signature based biomarkers for predicting clinical responses to immunotherapy. | Trine Vilsbøll Larsen Dianna Hussmann Anders Lade Nielsen | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | Metallurgical Studies of Austenitic Stainless Steel 304 under Warm Deep Drawing显示文摘Austenitic stainless steel 304 was deep drawn with different blank diameters under warm conditions using20 thydraulic press.A number of deep drawing experiments both at room temperature and at 150℃ were conducted to study the metallography.Also,tensile test experiments were conducted on a universal testing machine up to 700 ℃and the broken specimens were used to study the fractography of the material using scanning electron microscopy in various regions.The microstructure changes were observed at limiting draw ratio(LDR)when the cup is drawn at different temperatures.In austenitic stainless steel,martensite formation takes place that is not only affected by temperature,but also influenced by the rate at which the material is deformed.In austenitic stainless steel 304,dynamic strain regime appears above 300℃ and it decreases the formability of material due to brittle fracture as studied in its fractography.From the metallographic studies,the maximum LDR of the material is observed at 150 ℃ before dynamic strain regime.It is also observed that at 150 ℃,grains are coarse in the drawn cups at LDR. | Jayahari Lade Balu Naik Banoth Amit Kumar Gupta Swadesh Kumar Singh | 2014 | Journal of Iron and Steel Research(International)2014，21，12： | 2 |
| 3 | Distortion invariant object recognition in the dynamic link architecture 显示文摘 | Lades M Vorbroggen C J Buhmann J | 1993 | IEEE Transactions on Computer1993，42，3： | 2 |
| 4 | Significance of Particle Crushing in Granular Materials显示文摘 | Poul V. Lade Jerry A. Yamamuro Paul A. Bopp | 1996 | Journal of Geotechnical Engineering1996，，4： | 2 |
| 5 | Evolution of time dependent behavior of soils显示文摘 | AUGUSTESEN A LIINGAARD M LADE P V | 2004 | International Journal of Geomechanics2004，4，3： | 1 |
| 6 | Significance of particle crushing in granular materials显示文摘 | LADE PV YAMAMURO J A BOPP P A | 1996 | Journal of Geotechnical Engineering1996，122，4： | 1 |
| 7 | Effects of voids and volume changes on the behavior of frictional materials显示文摘 | Lade P V | 1988 | International Journal for Numerical and Analytical Methods in Geomechanics1988，12，： | 1 |
| 8 | Influence of time effects on instability of granular materials显示文摘 | LADE P V YAMAMURO J A BOPP P A | 1997 | Computers and Geotechnics1997，20，34： | 1 |
| 9 | The concept of effective stress for soil, concrete and rock 显示文摘 | Lade P V De Boer R | 1997 | Gfiotechnique1997，47，1： | 1 |
| 10 | Distortion invariant object recognition in the dynamic link architecture 显示文摘 | Lades M Vorbriiggen J C Buhmann J | 1993 | IEEE Transactions on Computers1993，42，3： | 1 |
| 11 | Expimental study of drained creep behavior of sand 显示文摘 | LADE P V LIU C T | 1998 | Journal of Engineering Mechanics1998，124，8： | 1 |
| 12 | Time effects relate to crushing in sand显示文摘 | KARIMPOUR H LADE P V | 2010 | Joumal of Geotechnical and Geoenvironmental Engineering2010，136，9： | 1 |
| 13 | Strain increment and stress directions in torsion shear tests显示文摘 | HONG W P LADE P V | 1989 | Journal of Geotechnical Engineering1989，115，10： | 1 |
| 14 | Anisotropic three-dimensional behavior of a normally consolidated clay显示文摘 | Kirkga M M Lade P V | 1993 | Canadian Geotechnical Journal1993，30，84： | 1 |
| 15 | Concept of effective stress for soil, concrete and rock 显示文摘 | Lade P V De Boer R | 1997 | Geotechnique1997，47，1： | 1 |
| 16 | Distortion invariant object recognition in the dynamic link architecture 显示文摘 | | 1993 | IEEE Trans on Computers1993，42，3： | 1 |
| 17 | Distortion invariant object recognition in the dynamic link architecture显示文摘 | Lades M Vorbmggen J C Buhmann J | 1993 | IEEE Transactions on Computers IEEE1993，42，3： | 1 |
| 18 | Distortion invariant object recognition in the dynamic link architecture 显示文摘 | Lades M Vorbruggen J C Buhmann J | 1993 | IEEE Transactions on Computers1993，42，3： | 1 |
| 19 | Significance of particlecrushing in granular materials显示文摘 | LADE P V YAMAMURO J A | 1996 | Journal of GeotechnicalEngineering ASCE1996，122，4： | 1 |
| 20 | Three-dimensional Behavior of Remolded Clay显示文摘 | Duncan J M | 1978 | J Geotech Eng ASCE1978，104，2： | 1 |
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