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| 1 | Liver injury in the era of COVID-19显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has undoubtedly revolutionized the whole globe and given a new point of view on respiratory tract infections.Nevertheless,coronavirus disease 2019(COVID-19)cannot be perceived as a disease limited only to pneumonia with diverse severity.More and more reports have demonstrated a wide range of possible systemic symptoms,including hepatic complications.Liver injury has been observed in a significant proportion of patients,especially in those with a severe or critical illness.COVID-19 might provoke a deterioration of liver function in patients with already diagnosed chronic liver diseases and without pre-existing liver disorders.The deterioration of liver function worsens the prognosis,increases the risk of a severe course of SARS-CoV-2 infection and prolongs the hospital stay.In general,patients who develop liver dysfunction in COVID-19 are mainly males,elderly people,and those with higher body mass index.The underlying mechanisms for hepatic failure in patients infected with SARS-CoV-2 are still unclear,nevertheless liver damage appears to be directly connected with virus-induced cytopathic effects.A liver injury observed during hospitalization might be simultaneously caused by the use of potentially hepatotoxic drugs,mainly antiviral agents.This minireview focuses on a possible relationship between COVID-19 and the liver,potential molecular mechanisms of liver damage,the characteristics of liver injury and suggested factors predisposing to hepatic manifestations in COVID-19 patients. | Halina Cichoż-Lach Agata Michalak | 2021 | World Journal of Gastroenterology2021，27，5： | 6 |
| 2 | Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease显示文摘BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth exploring.There are still plenty of unresolved issues related to the actual role of hematological indices as potential markers of liver function.AIM To study red blood cell distribution width(RDW),RDW-to-platelet ratio(RPR)and RDW-to-lymphocyte ratio(RLR) in alcohol-related liver cirrhosis(ALC) and metabolic-associated fatty liver disease(MAFLD).METHODS The study group was composed of 302 people:142 patients with ALC and 92 with MAFLD;68 persons were included as controls.RDW,RPR and RLR were measured in each person.Indirect and direct parameters of liver fibrosis were also assessed [aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index(APRI),fibrosis-4(FIB-4),gamma-glutamyl transpeptidase to platelet ratio(GPR),procollagen I carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,plateletderived growth factor AB,laminin].MELD score in ALC patients and nonalcoholic fatty liver disease(NAFLD) fibrosis score together with BARD score were obtained in the MAFLD group.The achieved results were compared to controls.Then a correlation between assessed markers was done.Diagnostic value of each investigated parameter and its suggested cut-off in the research group RESULTS RDW,RPR and RLR values turned out to be significantly higher in ALC and MAFLD groups compared to controls(ALC:P<0.0001;NAFLD:P<0.05,P<0.0001 and P<0.0001,respectively).RPR correlated positively with MELD score(P<0.01) and indirect indices of liver fibrosis(FIB-4 and GPR;P<0.0001) in ALC patients;negative correlations were found between PDGF-AB and both:RDW and RPR(P<0.01 and P<0.0001,respectively).RPR correlated positively with NAFLD fibrosis score and APRI(P<0.0001) in the MAFLD group;a positive relationship was observed between RDW and FIB-4,too(P<0.05).AUC values and suggested cut-offs for RDW,RPR and RLR in ALC patients were:0.912(>14.2%),0.965(>0.075) and 0.914(>8.684),respectively.AUC values and suggested cut-offs for RDW,RPR and RLR in MAFLD patients were:0.606(>12.8%),0.724(>0.047) and 0.691(>6.25),respectively.CONCLUSION RDW with its derivatives appear to be valuable diagnostic markers in patients with ALC.They can also be associated with a deterioration of liver function in this group. | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Tomasz Lach Halina Cichoż-Lach | 2022 | World Journal of Gastroenterology2022，28，38： | 4 |
| 3 | Computational Modelling of Retrofitting a Coal Fired Boiler Type OP-230 for Predicting NOX Reduction显示文摘This study focuses on a CFD modelling of biomass-derived syngas co-firing with coal in an older mid-sized PC-fired boiler of type OP-230 with low-emission burners on the front wall. The simulations were performed to determine whether the boiler can be retrofitted for the fulfilment of the prospective environmental protection regulations relating to levels of NO_X emissions. The improvement of the air staging via the dual-fuel technique was based on the indirect co-firing technology. The impact of two arrangements of dedicated syngas nozzles(below and above the existing coal burners), two syngas compositions and two heat replacements(5% and 15%) on the course of thermal processes in a furnace was tested. The reductions in NO_X emissions were predicted relative to the baseline when only coal is combusted. The highest reduction of about 38% was achieved with the syngas nozzles below the existing coal burners and 15% heat replacement. This arrangement of nozzles offers the residence time sufficient to co-fire coal with waste derived syngas. A lower reduction in NO_X emissions was obtained with the nozzles above the burners as the enlargement of local fuel rich zone near syngas injection becomes significant for 15% heat replacement. Results provide for the decreasing impact of methane content along with the increase of syngas heat input. The avoided CO_2 emissions through the syngas indirect co-firing with coal in the boiler are linear function of heat replacements. | MOTYL Przemyslaw LACH Jan | 2018 | Journal of Thermal Science2018，27，5： | 2 |
| 4 | Patents anti Productivity Growth at the Industry Level: A First Look 显示文摘 | Lach S | 1995 | Economies Letters1995，49，： | 1 |
| 5 | Predicting the probability of meningiomas recurrence based on the quantity of peritumoral brain edema on computerized tomography scanning显示文摘 | Mantle RE Lach B Delgado MR | 1999 | J Neurosurg1999，91，2： | 1 |
| 6 | Detection statistics for a pulsed laser radar显示文摘 | J A Schell G Lachs | 1971 | IEEE Transactions on Aerospace and Electronic Systems1971，7，6： | 1 |
| 7 | Asphyxia - related deaths 显示文摘 | Klaus Puschel Elisabeth TUrk Holger Lach | 2004 | Forensic Sci Int2004，144，7： | 1 |
| 8 | Spontaneous anaplasia in pilocytic astrocytoma of cerebellum显示文摘 | Lach B Al Shail E Patay Z | 2003 | Br J Neurosurg2003，17，3： | 1 |
| 9 | Predicting the probability of meningioma recurrence based on the quantity of peritumoral brain edema on computerized tomography scanning显示文摘 | Mantle RE Lach B Delgado MR | 1999 | J Neurosurg1999，91，3： | 1 |
| 10 | Environmental and economic costs of nonindigenous species in the United States显示文摘 | Pimentel D Lach L Zuniga R | 2000 | BioScience2000，50，1： | 1 |
| 11 | Role of NPY Y1 receptor on acquisition, consoli- dation and extinction on contextual fear conditioning:dissociation be- tween anxiety,locomotion and non - emotional memory behavior 显示文摘 | Lach G de Lima TC | 2013 | Neurobiol Learn Mem2013，103，： | 1 |
| 12 | Broadband Software-Radio Spread-Specmun Communications Using Time-Frequency Distribution Synthesis 显示文摘 | Stephen R Lach Moeness G Interference Excision for Amin Alan R Lindsey | 1999 | IEEE Journal on Selected Areas in Communication (S0733-8716)1999，17，4： | 1 |
| 13 | Modulation formats for 100 G and beyond 显示文摘 | Eugen Lach Wilfried | 2011 | Opt FiberTechnol2011，17，5： | 1 |
| 14 | Role of NPY Yl receptor on acquisition, consolidation and extinction on contextual fear conditioning: Dissociation between anxiety, locomotion and non-emotional memory behavior 显示文摘 | Lach G | 2013 | Neurobiol Learn Mem2013，103，： | 1 |
| 15 | Effects of rubber content and temperatureon unstable fracture behavior in ABS materials with differentparticle sizes显示文摘 | Lach B R Grellmann W | 2001 | Journal of Applied Polymer Science2001，79，1： | 1 |
| 16 | Predicting the Probability of Meningioma Recurrence based on the quantity of Peritumoral brain edema on computerized tomography scanning显示文摘 | Mantle RE Lach B Deigado MR | 1999 | J Neurosurg1999，91，9： | 1 |
| 17 | Structure - function analysis of the antioxidant properties of haptoglobin 显示文摘 | Melamed M Lache O Enav B I | 2001 | Blood2001，98，13： | 1 |
| 18 | Estimation of phase velocities at floodingpoint in packed columns for any gas/liquid system 显示文摘 | Kuzniewska lach I | 1999 | TheCanadian Journal of Chemical Engineering1999，77，3： | 1 |
| 19 | Area-wide system protection scheme against extreme contingencies显示文摘 | LACHS W R | 2005 | Proceedings of the IEEE2005，93，5： | 1 |
| 20 | The trial of regeneration of used impregnated activated carbons after manganese sorption 显示文摘 | Okoniewska E Lach J Kacprzak M | 2008 | Desalination2008，，223： | 1 |
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