|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Construction of regular and ir-regular shearlets 显示文摘 | KUTYNIOK G LAB ATE D | 2007 | Joumal of Wavelet Theory and Appli-cations2007，1，： | 1 |
| 3 | The solar radiation between 3,300and 12,500显示文摘 | NECKEL H LABS D | 1984 | Solar Physics1984，90，： | 1 |
| 4 | Mechanoeleetric contributions to sudden cardiac death显示文摘 | Lab MJ | 2001 | Cardiovase Res2001，50，2： | 1 |
| 5 | The solar spectral irradiance from 200 to 2400 mn as measured by the SOLSPEC spectrometer from the Atlas and Eureca missions 显示文摘 | Thuiltier G Herse M Labs D | 2003 | Solar Physics2003，214，1： | 1 |
| 6 | Heterogeneous changes of monophasic action potential induced by sustained stretch in atrium显示文摘 | Babuty D Lab MJ | 2001 | J Cardiovasc Electrophysiol2001，12，： | 1 |
| 7 | The solar spec-tral irradiance from 200 to 2400 nm as measured by the SOLSPEC spectrometer from the ATLAS and EURECA missions显示文摘 | THUILLIER G HERSE M LABS D | 2003 | Solar Physics2003，214，： | 1 |
| 8 | Primary vesical clear cell adenocarcinoma arising in endometriosis: a rare case of mullerian origin显示文摘 | Lab K Desai D Hadway P | 2013 | Anticancer Res2013，33，： | 1 |
| 9 | The solar spectral irradiance from 200-2400 nm as measured by the SOLSPEC spectrometer from the ATLAS and EURECA missions 显示文摘 | Thuillier G Herse M Labs D | 2003 | Solar Phys2003，214，1： | 1 |
| 10 | Genetic association with response to intravitreal ranibizumab in patients with neovascular AMD 显示文摘 | Kloeckener-Gruissem B Barthelmes D Labs S | 2011 | Invest Ophthalmol Vis Sci2011，52，： | 1 |
| 11 | The solar radiation between 3300 and 12500A显示文摘 | NECKEL H LABS D | 1984 | Solar Physics1984，90，： | 1 |
| 12 | The Integrated Model of Embedded Management Systems and Its Implementation显示文摘The Simple Network Management Protocol( SNMP ) is nowadays the key enabling management technology, while Web technologies have proved to be attractive to networks and systems management. Future development in the management domain should be 'integrated'. In this article, an embedded management model, which provides an integrated device management framework, is presented. This model consists of five functional modules including System service layer, Application layer, Data layer, Middle layer and Access layer. Each module is described, with the mutual relation included. Then the key points of implementation are discussed. And the system design with the development tools provided by WindRiver Systems, which enable products to be developed cost effectively and efficiently, is described in detail. | LIU Hong, DING Wei (Broadband Communication Network R&D Lab, Beijing University of Posts and Telecommunications, Beijing 100876, P.R.China) | 2002 | The Journal of China Universities of Posts and Telecommunications2002，9，3： | 1 |
| 13 | Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells显示文摘 | KORCHEV YE RAVAL M LAB MJ GORELIK J EDWARDS CR RAYMENT T Kenerman D | 2000 | Biophys J2000，78，5： | 1 |
| 14 | Solar limb darkening 1986-1990 (h303 to 1099 nm) 显示文摘 | Neckel H Labs D | 1994 | Solar Physics1994，153，12： | 1 |
| 15 | The solar spectral irradiance from 200 to 2400 nm as measured by the SOLSPEC spectrometer from the Atlas and Eureca missions显示文摘 | Thuillier G Hers M Labs D | 2003 | Solar Physics2003，214，1： | 1 |
| 16 | Inhibitory effect of procyanidin-rich extracts on LDL oxidation in vitro显示文摘 | Mazur A Bayle D Lab C | 1999 | Atherosclerosis1999，145，： | 1 |
| 17 | Germination of cotton cultivar seeds under water stressinduced by polyethylene glycol - 6000 显示文摘 | Carlos H S G M Riselane LAB Pedro D F | 2011 | Sci Agric(Piracicaba Braz)2011，68，2： | 1 |
| 18 | The Solar Spectral Irradiance from 200 to 2400 nm as Measured by the SOLSPEC Spectrometer from the ATLAS and EURECA Missions显示文摘 | Thuillier G Herse M Labs D | 2003 | Solar Physics2003，214，1： | 1 |
| 19 | The solar radiation between 3 300 and 12 500 显示文摘 | NECKEL H LABS D | 1984 | Solar Physics1984，90，： | 1 |
| 20 | The solar radiation between 3300 and12500 Angstroms显示文摘 | Neckel H Labs D | 1984 | Solar Physics1984，90，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员