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| 1 | Controlled release of FK506 from micropatterned PLGA films:potential for application in peripheral nerve repair显示文摘After decades of research,peripheral nerve injury and repair still frequently results in paralysis,chronic pain and neuropathies leading to severe disability in patients.Current clinically available nerve conduits only provide crude guidance of regenerating axons across nerve gap without additional functionality.FK506(Tacrolimus),an FDA approved immunosuppressant,has been shown to enhance peripheral nerve regeneration but carries harsh side-effects when delivered systemically.The objective of this study was to develop and evaluate a bioresorbable drug delivery system capable of local extended delivery of FK506 that also provides topological guidance cues to guide axon growth via microgrooves.Photolithography was used to create micropatterned poly(lactide-co-glycolic acid)(PLGA) films embedded with FK506.Non-patterned,10/10 μm(ridge/groove width),and 30/30 μm patterned films loaded with 0,1,and 3 μg/cm2 FK506 were manufactured and characterized.In vitro FK506 rate of release testing indicated that the films are capable of an extended(at least 56 days),controlled,and scalable release of FK506.Neurite extension bioactivity assay indicated that FK506 released from the films(concentration of samples tested ranged between 8.46–19.7 ng/m L) maintained its neural bioactivity and promoted neurite extension similar to control FK506 dosages(10 ng/m L FK506).The multi-functional FK506 embedded,micropatterned poly(lactide-co-glycolic acid) films developed in this study have potential to be used in the construction of peripheral nerve repair devices. | Brett Davis Susan Wojtalewicz Pratima Labroo Jill Shea Himanshu Sant Bruce Gale Jayant Agarwal | 2018 | Neural Regeneration Research2018，13，7： | 2 |
| 2 | J Org Chem显示文摘 | Rajecwama W G Labroo R B Cohen L A | 1999 | 64(4):1369-13711999，64，4： | 1 |
| 3 | The Effect of Conceptual and PerceptualFluency on Brand Evaluation显示文摘 | Lee A Labroo A | 2004 | Journal of Marketing Re-search2004，41，2： | 1 |
| 4 | The effect of conceptual and perceptual fluency on brand evaluation 显示文摘 | Lee A Y Labroo A | 2004 | Journal of Mar- keting Research2004，41，2： | 1 |
| 5 | Be better or be merry: How mood affects self-control显示文摘 | FISHBACH A LABROO A A | 2007 | J Personality Soc Psychol2007，93，2： | 1 |
| 6 | Be better or be merry: how mood affects self-control 显示文摘 | Fishbach A Labroo AA | 2007 | Journal of Personality and Social Psychology2007，93，2： | 1 |
| 7 | The Effect of Concep tual and PerceptualFluency on Brand Evaluation显示文摘 | Lee A Labroo A | 2004 | Journal of Marketing Re-search2004，41，2： | 1 |
| 8 | Synthesis of α-estradiol-3-benzoate-17-(succinyl-12α-tetracycline): a potential bone-seeking estrogen显示文摘 | Orme MW Labroo VM | 1994 | Bioorg Med Chem Lett1994，4，11： | 1 |
| 9 | The Effect of Conceptual and PerceptualFluency on Brand Evaluation显示文摘 | Lee A Labroo A | 2004 | Journal of Marketing Re-search2004，41，2： | 1 |
| 10 | Synthesis of β-estrodial-3-benzoate-17-(succinyl-12A-tetrocycline): a potential bone-seeking estrogen 显示文摘 | Orme MW Labroo VM | 1994 | Bioog Med Chem Lett1994，4，11： | 1 |
| 11 | An Influence of Product and Brand Name on Positive Affect:Implicit and Explicit Measures显示文摘 | ISEN M A LABROO A A DURLACH P | 2004 | Motivation and Emotion2004，28，1： | 1 |
| 12 | The Effect of Conceptual and Perceptu-al Fluency on Brand Evaluation显示文摘 | Lee A Labroo A | 2004 | Journal of MarketingResearch2004，41，2： | 1 |
| 13 | Be better or be merry:How mood affects self-control显示文摘 | Fishbach A Labroo A A | | 0，，93： | 1 |
| 14 | Fentany metabolism by human hepatic and intestinal cytochrome P4503A4 implication for interindividual variability in disposition,effcacy,and drug interactions显示文摘 | Labroo RB Paine MF Thumel KE | 1997 | Orug Metab Dispos1997，25，： | 1 |
| 15 | Fentanyl metabolism by human hepetic and intestinal cytochrome P4503A4 implication for interindividual variability in disposition, efficacy, and drug interactions显示文摘 | Labroo RB Paine MF Thummel KE | 1997 | Drug Metab Dispos1997，2，： | 1 |
| 16 | Of frowning watches and frog wines: semantic priming and visual fluency 显示文摘 | Labroo A Dhar R Schwarz N | 2008 | Journal of Consumer Research2008，，34： | 1 |
| 17 | Fentanyl metabolismby human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions显示文摘 | Labroo RB Paine MF Thummel KE | 1997 | Drug Metab Dispos1997，25，9： | 1 |
| 18 | From Firm Muscles to Firm Willpower Understanding the Role of Embodied Cognition in Self-Regulation 显示文摘 | HUNG I W LABROO A A | 2011 | Journal of Consumer Research2011，37，6： | 1 |
| 19 | Fentanyl metabolism by human Hepatic and intestinal cytoehlome P4503A4: im- plieations for interindividual Variability in disposition, efficaey, and drug interactions 显示文摘 | Labroo RB Paine MI7 Thummel KE | 1997 | Drug Metab DisPos1997，25，9： | 1 |
| 20 | Be better or be merry: How mood affects self-control显示文摘 | FISHBACH A LABROO A A | 2007 | J Personal Soc Psychol2007，93，2： | 1 |
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