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| 1 | Performance of silver nanoparticles in the catalysis of the oxygen reduction reaction in neutral media: Efficiency limitation due to hydrogen peroxide escape显示文摘为在盖住柠檬酸盐的银 nanoparticles 的中立 pH 的氧减小反应(ORR ) 的 electrocatalytic 活动(直径 = 18 nm ) 在玻璃质的碳(GC ) 上支持了 voltammetrically 被调查。使用新方法,由粘住形成一个随机的 nanoparticle 数组和 voltammetric 实验的 nanoparticles 的底层的修正被 GC 电极的沉浸同时执行在一浸透空气 0.1 M NaClO4 答案(pH = 5.8 ) 包含化学上综合的 nanoparticles。产生 nanoparticle 数组的试验性的 voltammograms 根据氧的二质子的、二电子的减小用自做的节目被模仿到第一电子转移是率决定的氢过氧化物。在银电极的情况中,产生的氢过氧化物进一步部分被减少经由异构的分解流水。在银 macroelectrode 和银 nanoparticles 上获得的结果的比较显示那,为在这研究采用的银 nanoparticles 和粒子报道(0.035%0.457%) , ORR 电极动力学更慢并且在玻璃质的支持碳的 nanoparticles 上更大的氢过氧化物的生产比上体积银。 | Christopher C. M. Neumann Eduardo Laborda Kristina Tschulik Kristopher R. Ward Richard G. Compton | 2013 | Nano Research2013，6，7： | 5 |
| 2 | Treatment of primary sclerosing cholangitis in children显示文摘Primary sclerosing cholangitis(PSC) is a rare disease of stricturing and destruction of the biliary tree with a complex genetic and environmental etiology.Most patients have co-occurring inflammatory bowel disease. Children generally present with uncomplicated disease, but undergo a variable progression to endstage liver disease. Within ten years of diagnosis, 50% of children will develop clinical complications including 30% requiring liver transplantation.Cholangiocarcinoma is a rare but serious complication affecting 1% of children.Ursodeoxycholic acid and oral vancomycin therapy used widely in children as medical therapy, and may be effective in a subset of patients. Gamma glutamyltransferase is a potential surrogate endpoint for disease activity, with improved survival in patients who achieve a normal value. Endoscopic retrograde cholangiopancreatography is a necessary adjunct to medical therapy to evaluate mass lesions or dominant strictures for malignancy, and also to relieve biliary obstruction. Liver transplantation remains the only option for patients who progress to end-stage liver disease. We review special considerations for patients before and after transplant, and in patients with inflammatory bowel disease. There is presently no published treatment algorithm or guideline for the management of children with PSC. We review the evidence for drug efficacy, dosing, duration of therapy, and treatment targets in PSC, and provide a framework for endoscopic and medical management of this complex problem. | Trevor J Laborda M Kyle Jensen Marianne Kavan Mark Deneau | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 3 | Hereditary pancreatitis:An updated review in pediatrics显示文摘Hereditary Pancreatitis(HP)has emerged as a significant cause of acute,acute recurrent and chronic pancreatitis in the pediatric population.Given that it presents similarly to other causes of pancreatitis,a positive family history and/or isolation of a gene mutation are vital in its designation.Inheritance patterns remain complex,but mutations involving the PRSS1,SPINK1,CFTR and CTRC genes are commonly implicated.Since being first described in 1952,dozens of genetic alterations that modify the action of pancreatic enzymes have been identified.Among children,these variants have been isolated in more than 50%of patients with chronic pancreatitis.Recent research has noted that such mutations in PRSS1,SPINK1 and CFTR genes are also associated with a faster progression from acute pancreatitis to chronic pancreatitis.Patients with HP are at increased risk of developing diabetes mellitus,exocrine pancreatic insufficiency,and pancreatic adenocarcinoma.Management follows a multi-disciplinary approach with avoidance of triggers,surveillance of associated conditions,treatment of pancreatic insufficiency and use of endoscopic and surgical interventions for complications.With significant sequela,morbidity and a progressive nature,a thorough understanding of the etiology,pathophysiologic mechanisms,diagnostic evaluation,current management strategies and future research considerations for this evolving disease entity in pediatrics is warranted. | Arvind Vasant Panchoo Grant H VanNess Edgardo Rivera-Rivera Trevor J Laborda | 2022 | World Journal of Clinical Pediatrics2022，11，1： | 2 |
| 4 | Dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line显示文摘 | Laborda J Sausville EA Hoffman T | 1993 | J Biol Chem1993，268，6： | 1 |
| 5 | T cell leukemia-associated human Notch/translocation-associated Notch homologue has IkB- like activity and physically interacts with nuclear factor-kB proteins in T cells显示文摘 | GUAN E WANG J LABORDA J | 1996 | J Exp Med1996，183，5： | 1 |
| 6 | Chemical charicterization of commercial soybean products 显示文摘 | Garcia MC Marina ML Laborda F | 1998 | Food Chemistry1998，62，3： | 1 |
| 7 | DLk,a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line显示文摘 | Laborda J Sausville EA Hoffman T | 1993 | J Biol Chem1993，268，6： | 1 |
| 8 | Determination of antimony by electrochemical hydride generation atomic absorption spectrgmetry in samples with high iron content using chelating resins as on-line removal system 显示文摘 | E Bolea D Arroyo F Laborda | 2006 | Analytica Chimica Acta2006，569，1： | 1 |
| 9 | Liquefaction and/ orsolubilization of Spanish coals by Newly isolatedmicroorganism 显示文摘 | Monistrol I F Laborda F | 1994 | Fuel Process Technology1994，40，3： | 1 |
| 10 | Hemoptysis workup before embolization, Single-Center Experience with a 15-year Period Follow-Up显示文摘 | De Gregorio MA Medrano J Laborda A | 2007 | Tech Vasc Interventional Radiol2007，10，： | 1 |
| 11 | T cell leukemia-associated human Notch/translocation- associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells显示文摘 | Guan E Wang J Laborda J Norcross M Baeuerle P A Hoffman T | 1996 | J Exp Med1996，183，： | 1 |
| 12 | Mouse resistin modu- lates adipogenesis and glucose uptake in 3T3-L1 preadipoeytes through the ROR1 receptor 显示文摘 | Sánchez-Solana B Laborda J Baladrón V | 2012 | Mol Endocrinol2012，26，1： | 1 |
| 13 | Processes of Liquefaction/Solubilization, of Spanish Coals by Microorganisms显示文摘 | Laborda F Monistrol I F Luna N | 1999 | Appl Microbiol Biotechnol1999，52，1： | 1 |
| 14 | The role of the epidermal growth factor-like protein dlk in cell differentiation显示文摘 | Laborda J | | 0，，： | 1 |
| 15 | Study of the Mechanisms by Which Microorganisms Solubilize and/or Liquefy Spanish Coal显示文摘 | Laborda F Femandez M Luna N | 1997 | Fuel Processing Technology1997，52，13： | 1 |
| 16 | Study ofthe Mechanisms Which Microorganisms Solubilize and /or Liquefy Spanish Coals显示文摘 | Laborda F Fernandez M Luna N Monistrol I F | 1997 | Fuel Processing Technology1997，52，1： | 1 |
| 17 | Prognostic factors associated with resectable pulmonary metastases from colorectal cancer显示文摘 | MuiiozLIare A Carrera Revilh S GilNegrete Laborda A | 2007 | Arch Bronconeumol2007，43，6： | 1 |
| 18 | 查看详情显示文摘 | F Laborda E Bolea J R Castillo | | 0，，： | 1 |
| 19 | Tubular electrolytic hydride generation for continuous and flow injection sample in atomic absorption spectrometry显示文摘 | LABORDA F BOLEA E LUAN R | 2000 | J Anal At Spectrom2000，15，3： | 1 |
| 20 | Mobilization and speciation of chromium in compost:A methodological approach显示文摘 | Laborda F Gorriz M P Bolea E | 2007 | Science of The Total Environment2007，373，1： | 1 |
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