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| 1 | Essential oils as alternatives to antibiotics in swine production显示文摘This review article summarizes the efficacy, feasibility and potential mechanisms of the application of essential oils as antibiotic alternatives in swine production.Although there are numerous studies demonstrating that essential oils have several properties, such as antimicrobial, antioxidative and antiinflammatory effects, feed palatability enhancement and improvement in gut growth and health, there is still a need of further investigations to elucidate the mechanisms underlying their functions.In the past,the results has been inconsistent in both laboratory and field studies because of the varied product compositions, dosages, purities and growing stages and conditions of animals.The minimal inhibitory concentration(MIC) of essential oils needed for killing enteric pathogens may not ensure the optimal feed intake and the essential oils inclusion cost may be too high in swine production.With the lipophilic and volatile nature of essential oils, there is a challenge in effective delivery of essential oils within pig gut and this challenge can partially be resolved by microencapsulation and nanotechnology.The effects of essential oils on inflammation, oxidative stress, microbiome, gut chemosensing and bacterial quorum sensing(QS) have led to better production performance of animals fed essential oils in a number of studies.It has been demonstrated that essential oils have good potential as antibiotic alternatives in feeds for swine production.The combination of different essential oils and other compounds(synergistic effect) such as organic acids seems to be a promising approach to improve the efficacy and safety of essential oils in applications.High-throughput systems technologies have been developed recently,which will allow us to dissect the mechanisms underlying the functions of essential oils and facilitate the use of essential oils in swine production. | Faith A.Omonijo Liju Ni Joshua Gong Qi Wang Ludovic Lahaye Chengbo Yang | 2018 | Animal Nutrition2018，，2： | 24 |
| 2 | Effect of dietary supplementation with protease on growth performance,nutrient digestibility, intestinal morphology, digestive enzymes and gene expression of weaned piglets显示文摘This study was conducted to investigate the effect of dietary protease supplementation on the growth performance, nutrient digestibility, intestinal morphology, digestive enzymes and gene expression in weaned piglets. A total of 300 weaned piglets(21 days of age Duroc x Large White x Landrace; initial BW = 6.27 ± 0.45 kg) were randomly divided into 5 groups. The 5 diets were: 1) positive control diet(PC), 2) negative control diet(NC), and 3) protease supplementations, which were 100, 200, and 300 mg per kg NC diet. Results indicated that final BW, ADG, ADFI, crude protein digestibility, enzyme activities of stomach pepsin, pancreatic amylase and trypsin, plasma total protein, and intestinal villus height were higher for the PC diet and the supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Supplementations of 200 and 300 mg protease per kg NC diet significantly increased the ratio of villus height to crypt depth(VH:CD) of duodenum, jejunum and ileum compared with NC diet(P < 0.05). Feed to gain ratio, diarrhea index, blood urea nitrogen, and diamine oxidase were lower for the PC diet and supplementations of 200 and 300 mg protease per kg NC diet than for the NC diet(P < 0.05). Piglets fed the PC diet had a higher peptide transporter 1(PepTl) mRNA abundance in duodenum than piglets fed the NC diet(P < 0.05), and supplementations of 100, 200 and 300 mg protease per kg NC diet increased the PepTl mRNA abundance in duodenum(P < 0.05) comparing with the NC diet. Piglets fed the PC diet had a higher b0,+AT mRNA abundance in jejunum than piglets fed the NC diet(P < 0.05), and supplementations of 200 and 300 mg protease per kg NC diet increased the b0,+AT mRNA abundance in jejunum and ileum comparing with the NC diet(P < 0.05). In summary, dietary protease supplementation increases growth performance in weaned piglets, which may contribute to the improvement of intestinal development, protein digestibility, nutrient transport efficiency, and health status of piglets when fed low digestible protein sources. | Jianjun Zuo Baoming Ling Lina Long Tiejun Li Ludovic Lahaye Chengbo Yang Dingyuan Feng | 2015 | Animal Nutrition2015，，4： | 18 |
| 3 | Prediction and diagnosis of colorectal anastomotic leakage: A systematic review of literature显示文摘Although many studies have focused on the preoperative risk factors of anastomotic leakage after colorectal surgery(CAL), postoperative delay in diagnosis is common and harmful. This review provides a systematic overview of all available literature on diagnostic tools used for CAL. A systematic search of literature was undertaken using Medline, Embase, Cochrane and Webof-Science libraries. Articles were selected when a diagnostic or prediction tool for CAL was described and tested. Two reviewers separately assessed the eligibility and level of evidence of the papers. Sixty-nine articles were selected(clinical methods: 11, laboratory tests: 12, drain fluid analysis: 12, intraoperative techniques:22, radiology: 16). Clinical scoring leads to early awareness of probability of CAL and reduces delay of diagnosis. C-reactive protein measurement at postoperative day 3-4 is helpful. CAL patients are characterized by elevated cytokine levels in drain fluid in the very early postoperative phase in CAL patients. Intraoperative testing using the air leak test allows intraoperative repair of the anastomosis. Routine contrast enema is not recommended. If CAL is clinically suspected, rectal contrast-computer tomography is recommended by a few studies. In many studies a 'no-test' control group was lacking, furthermore no golden standard for CAL is available. These two factors contributed to a relatively low level of evidence in the majority of the papers. This paper provides a systematic overview of literature on the available tools for diagnosing CAL. The study shows that colorectal surgery patients could benefit from some diagnostic interventions that can easily be performed in daily postoperative care. | Freek Daams Zhouqiao Wu Max Jef Lahaye Johannus Jeekel Johan Frederik Lange | 2014 | World Journal of Gastrointestinal Surgery2014，6，2： | 10 |
| 4 | Zinc Fingers, TAL Effectors, or Cas9-Based DNA Binding Proteins: What's Best for Targeting Desired Genome Loci?显示文摘ZINC FINGER-AND TAL EFFECTORBASED DNA BINDING PROTEINS Programmable DNA binding proteins (PDPs) that selectively bind user-defined nucleotide sequences can navigate protein domains to any desired target within the genome.Different functional domains can be fused to PDPs to achieve (1) activation or repression of transcription,(2) nicking or cleavage of DNA,or (3) modification or removal of epigenetic marks at the targeted genome spot.Given their broad applicability,the development of highly specific,easy-to-use PDPs has been a holy grail of biotechnology since the determination of the 3-D structure of zinc fingers (ZFs) bound to DNA in 1991 (Pavletich and Pabo,1991). | Annett Strauβ Thomas Lahaye | 2013 | Molecular Plant2013，6，5： | 6 |
| 5 | 蛋白酶在动物生产中的应用显示文摘蛋白原料价格昂贵、环境问题以及蛋白酶相对其他饲料添加剂具有更好的可获得性,使蛋白酶在动物营养中的应用也越来越受到高度关注。蛋白酶能够提高单胃动物对蛋白质、多肽及氨基酸的消化能力,同时改善单胃动物消化生理功能。在家禽营养中,使用蛋白酶可提高家禽的生产性能,或者在使用相对便宜的配方饲料喂养家禽时维持家禽的生产性能。蛋白酶在猪营养中的应用可促进断奶仔猪的生长,减少某些饲料原料中抗营养因子的负面影响。在水产养殖中应用蛋白酶能保持或改善水产动物生产性能的前提下,通过降低鱼粉用量、应用植物蛋白原料及其它非常规植物蛋白原料来降低饲料成本。 | Ludovic Lahaye Robert Gauthier 熊玲玲 | 2011 | 饲料与畜牧(新饲料)2011，，7： | 4 |
| 6 | Structural studies on agar fractions extracted sequentially from chinese red sea weeds:Gracilaria sjeostedtii, G. textorii andG. salicornia using13C-NMR and IR spectroscopy显示文摘 | Ji Minghou M. Lahaye W. Yaphe | 1988 | Chinese Journal of Oceanology and Limnology1988，，2： | 2 |
| 7 | Inhomogeneous distribution of REE in scheelite and dynamics of Archaean hydrothermal systems (Mt. Charlotte and Drysdale gold deposits, Western Australia)显示文摘 | Jo?l Brugger Yann Lahaye Sylvie Costa David Lambert Roger Bateman | 2000 | Contributions to Mineralogy and Petrology2000，，3： | 2 |
| 8 | 责任金融:将原则付诸实践显示文摘小额金融具有双重底线的特征,近年来爆发的信贷危机凸显双重底线之间存在的矛盾冲突。基于此,有必要对双重底线进行重新平衡,而出路就是实施责任金融战略。文章首先界定了责任金融的内涵;随后从行业自我监管、政府监管、消费者能力提高三个方面探讨了责任金融对客户保护的三个战略;最后结合实践发展现状提出了推动责任金融发展的建议。 | Mekee,Lahaye Koning | 2013 | 科学决策2013，，11： | 2 |
| 9 | Cell-wall polysaccharides from the marine green alga Ulva rigida (Ulvales,Chlorophyta) Chemical structure of ulvan显示文摘 | Ray B Lahaye M | 1995 | Carbohydrate Research1995，274，： | 1 |
| 10 | Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers显示文摘 | Sebastian Bultmann Robert Morbitzer Christine S. Schmidt Katharina Thanisch Fabio Spada Janett Elsaesser Thomas Lahaye Heinrich Leonhardt | 2012 | Nucleic Acids Research2012，，12： | 1 |
| 11 | The tomato resistance protein Bs4 is a predicted non-nuclear TIR-NB-LRR protein that mediates defense responses to severely truncated derivatives of AvrBs4 and overexpressed AvrBs3显示文摘 | Schornack S Ballvora A Gürlebeck D Peart J Ganal M Baker B Bonas U Lahaye T | 2004 | The Plant Journal2004，37，1： | 1 |
| 12 | DNA barcoding the floras of biodiversity hotspots显示文摘 | Lahaye R Warner J Bogarin D | 2008 | Proc Natl Acad Sci USA2008，105，8： | 1 |
| 13 | Cloning and sequencing of the PIF gene involved in repair and recombination of yeast mitochondrial DNA 显示文摘 | Foury F Lahaye A | 1987 | EMBO1987，6，5： | 1 |
| 14 | Inhibition of the oxidation of carbon-carbon composite by boron oxide 显示文摘 | Baranne P Lahaye J | 1986 | Carbon1986，24，4： | 1 |
| 15 | Mill after chemoradiotherapy of rectal cancer: a useful tool to select patients for local excision 显示文摘 | Engelen SM Beets-Tan RG Lahaye M J | 2010 | Dis Colon Rectum2010，53，7： | 1 |
| 16 | 中国江蓠属红藻所含琼胶的结构特征显示文摘 | 纪明侯 M. Lahaye W. Yaphe | 1986 | 海洋与湖沼1986，，01： | 1 |
| 17 | The influence of impurities contained in quartz sand on the catalytic reduction of nitric oxide by carbon monoxide显示文摘 | LAHAYE I | 1996 | Appl Surf Sci1996，93，2： | 1 |
| 18 | DNA barcoding the floras of biodiversity hotspots显示文摘 | Lahaye R van der Bank M Bngarin D | 2008 | Proceedings of the National Academy of Sciences USA2008，105，： | 1 |
| 19 | Hsp70 pro-tein positively regulates rabies virus infection 显示文摘 | Xavier Lahaye Aurore Vidy Baptiste Fouquet | 2012 | Virology2012，86，9： | 1 |
| 20 | Chromosome landing at the barley rar 1 locus显示文摘 | SHRRASN K SCHULZE L P | 1998 | Mol Gen Genet1998，20，： | 1 |
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