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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | Optimal reduction of linear systems显示文摘 | Luus R | 1999 | J of Franklin Institute1999，336，3： | 2 |
| 5 | Simultaneous stabilization of linear single-input systems by linear state feedback control显示文摘 | Howitt G D Luus R | 1991 | Int J of Control1991，54，5： | 1 |
| 6 | Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma显示文摘 | Luu H H Zhou Haydon R C | 2005 | Cancer Letters2005，229，1： | 1 |
| 7 | Optimization by direct search and systematic reduction of the size of search region显示文摘 | LUUS R JAAKOLA T H I J | 1973 | AICHE1973，19，3： | 1 |
| 8 | Toxicogenomics of A375 hunmn malignant melanoma cells treated with arbutin 显示文摘 | CHENG S K LUU R H SHEU J N | 2007 | Journal of Biomedical Science2007，14，1： | 1 |
| 9 | The adsorption of microcystin-LR by natural clay particles 显示文摘 | Morris R J Williams D E Luu He A | 2000 | Toxicon2000，38，2： | 1 |
| 10 | Modeling of army research laboratory EMP simulators显示文摘 | Miletta J R Chase R J Luu B B | 1993 | IEEE Trans on Nuclear Science1993，40，6： | 1 |
| 11 | Optimization of fed-batch reactors by the Luus-Jaakola optimization procedure 显示文摘 | LUUS R HENNESSY D | 1999 | Industrial & Engineering Chemistry Research1999，38，： | 1 |
| 12 | Hadrosaurian dinosaurs of North America显示文摘 | LuU R S Wright N E | 1942 | Geological Society of America Special Paper1942，40，： | 1 |
| 13 | Paclitaxel reduces regulatory T cell numbers and inhibitory function and enhances the antitumor effects of the TLR9 agonist PF-3512676 in the mouse 显示文摘 | Vicari AP Luu R Zhang N | 2009 | Cancer Immunol Immunother2009，58，4： | 1 |
| 14 | Optimization by direct search and systematic reduction of the size of search region显示文摘 | Luus R Jaakola THI | 1973 | AIChE1973，19，4： | 1 |
| 15 | The adsorption of microcystin-LR by natural clay particles显示文摘 | MORRIS R J WILLIAMS D E LUU H A | 2000 | Toxicon2000，38，2： | 1 |
| 16 | Optimal switching control via direct searchoptimization 显示文摘 | Luus R Chen Y Q | 2004 | Asian Journal of Control2004，6，2： | 1 |
| 17 | Optimization of system reliability by a new nonlinear integer programming procedure显示文摘 | Luus R | 1985 | IEEE Trans Reliability1985，24，： | 1 |
| 18 | Trajectories of receptive language development from 3 to 12 years of age for very preterm children显示文摘 | Luu TM Vohr BR Schneider KC Katz KH Tucker R Allan WC | 2009 | Pediatrics2009，124，1： | 1 |
| 19 | Optimal Switching Control Via Direct Search Optimization显示文摘 | Luus R Chen YangQuan | 2003 | IEEE on Deision and contool2003，，： | 1 |
| 20 | Evidence for catch-up in cognition and receptive vocabulary among ado- lescents hom very preterm 显示文摘 | Thuy Mai Luu Betty R Walter Allan | 2011 | Pediatrics2011，128，2： | 1 |
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