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| 1 | 锡林河流域地表水水化学主离子特征及控制因素显示文摘通过对2006~2008年锡林河主要径流期内13个河水断面239个水样以及同期地下水和大气降水主离子水化学进行分析,结合锡林河流域的气象和水文资料,利用Piper三线图和Gibbs图分析了锡林河河水的水化学特征及主离子组成变化特征.结果表明,锡林河河水TDS变化范围在136.7~376.5mg·L^-1之间,平均245.1mg·L^-1,为低矿化度河水;河水中主要阳离子以Ca2+为主,阴离子以HCO3^-为主,河水的水化学类型从HCO3-—Ca2+过渡到HCO3--Ca2+·Mg2+;河水主离子平均浓度年内、年际变化均不大,年内变化表现在5月主离子浓度高于其他月,年际变化表现为主离子在2007年的平均浓度均较小;空间上,Ca2+、Na+、Mg2+、K+、Cl^-和HCO3^-的浓度呈现沿程逐渐增加的趋势,SO4^2-的浓度变化呈先增加后减小的趋势;河水中主离子浓度值介于大气降水和地下水之间,并且十分接近地下水浓度,说明地表水同时受大气降水和地下水补给并主要依靠地下水补给;Gibbs图显示河水离子组成主要与流域内的岩石风化有关,流域有一定量的蒸发岩存在,但蒸发岩对水化学的贡献弱于碳酸盐岩. | 唐玺雯 吴锦奎 薛丽洋 张明泉 Frauke Barthold Lutz Breuer Hans-Georg Frede | 2014 | 环境科学2014，35，1： | 61 |
| 2 | 煤矸石充填复垦地理化特性与重金属分布特征显示文摘为研究煤矸石充填复垦地农作物产量达到最佳时的覆土厚度及煤矸石充填复垦地重金属分布状况,该文以新庄孜矿煤矸石充填复垦地作为研究对象,采取室外田间小区试验和室内试验分析方法,选取不同覆土厚度50~60,60~70,70~80,80~90 cm的4类试验地块及对照地块对其土壤理化性质及农作物根系分布、长势产量、重金属元素含量进行调查分析,发现复垦地块各项指标与对照地块差异显著,劣于对照地块;煤矸石充填基质土壤理化性质较差;70~80 cm的厚度是煤矸石充填复垦造地较经济合理的覆土厚度。煤矸石复垦地重金属元素有向上迁移的趋势;复垦土壤及煤矸石基质中Pb、Zn、Cr元素含量处于安全水平;大部分监测的Cu、Ni、Cd元素含量高于淮南土壤背景值,低于中国土壤环境质量标准二级标准,对复垦土壤已构成潜在的威胁性,应予以重视;覆土厚度50~60 cm地块的煤矸石基质中Cu、Ni元素含量处于安全水平,煤矸石基质中Cd元素含量高于淮南土壤土壤背景值,低于中国土壤环境质量标准二级标准,应予以重视。结果表明70~80 cm的厚度是煤矸石充填复垦造地最佳覆土厚度;新庄孜煤矸石充填复垦地重金属有向上迁移的趋势,复垦土壤中重金属含量符合国家二级标准,未出现重金属污染情况,但部分重金属元素含量高于淮南市土壤背景值,应予以重视。 | 徐良骥 黄璨 章如芹 刘会平 严家平 Helmut Meuser Lutz Makowsky | 2014 | 农业工程学报2014，30，5： | 62 |
| 3 | 城市环境气候图的发展及其应用现状显示文摘城市环境气候图最初于20世纪70年代由德国气候研究者开发制作,通过近40年的发展,目前在世界范围内已有20个国家开展了相关研究与应用项目,从而为改善城市气候环境与提高人居生活条件提供决策依据。该文首先对城市环境气候图的发展及其制作方法进行了一个总体性的回顾,然后选取德国、日本和中国香港地区的研究案例用以考察目前该领域研究和应用现状与存在问题,进一步详细探讨了未来发展的方向,最后指出了在我国城市化进程中为应对诸多气候环境问题所迫切需要开展的相关研究问题。 | 任超 吴恩融 Katzschner Lutz 冯志雄 | 2012 | 应用气象学报2012，23，5： | 35 |
| 4 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 5 | 令牌目的循环时间T_(TR)对现场总线PROFIBUS测控周期的影响显示文摘在对PROFIBUS的令牌总线协议深入分析的基础上,讨论了影响基于PROFIBUS的现场总线系统的测控周期的因素,通过对令牌目的循环时间TTR不同设置对测控周期时间影响的具体分析,得出两个主要的结论:(1 )测控周期是在一定范围内随着TTR的增加而增加,之后将不随TTR变化;(2 )将TTR置于令牌的最小周转时间W时,高优先级任务能获得最短实时响应,但低优先级任务将得不到响应处理。文中还详细描述了一个具有两个主站、五个从站的实验系统的构成和实验过程。 | 侯维岩 费敏锐 阳宪惠 Lutz Rauchhaupt | 2005 | 仪器仪表学报2005，26，4： | 19 |
| 6 | 基于粉煤灰基质充填覆土复垦的最佳覆土厚度显示文摘为研究粉煤灰充填复垦地种植农作物的经济产量达到最优时的最佳覆土厚度,选择淮南上窑粉煤灰场复垦地为研究对象,选取不同厚度覆土(A:<40 cm;B:40~55 cm;C:55~70 cm;D:>70 cm)的地块采样监测冬小麦的经济产量、根长密度、土壤含水量、土壤pH、土壤N,P,K营养元素含量等指标。实验结果表明:有利于冬小麦生长并得到最佳产量的适宜覆土厚度为55~70 cm,其土壤pH为8.15,N,P,K含量分别为6.272,26.253,143.76 mg/kg。综合评价结果表明该地块的表土具有较好的营养能力,土壤质量较好。 | 徐良骥 许善文 严家平 MEUSER Helmut MAKOWSKY Lutz WEISS Eltje MAX Bjorn | 2012 | 煤炭学报2012，37，A02： | 13 |
| 7 | 粉煤灰充填复垦地理化特性与重金属分布特征研究--以淮南洛河电厂粉煤灰复垦地为例显示文摘本文以淮南上窑储灰场中的粉煤灰充填复垦地为研究对象,选择粉煤灰复垦地与灰场周边非复垦区对照地块进行布点采样,在复垦地中分六层[H1(0~20cm)、H2(20~40cm)、H3(40~60cm)、H4(60~80cm)、H5(80~100cm)、H6(100~120cm)]分别采集土壤、粉煤灰样品并进行监测,对照地块按照同样方法采样监测,分析复垦地土壤理化性质和重金属的分布特征。研究结果显示,随着采样深度的增加,复垦地pH值从8.21到8.49呈递增的空间分布特征,各采样层pH值均高于对照地块;随着采样深度的增加,复垦地的含水量呈增加的空间分布特征,对照地块的含水量则是先增加后减少,粉煤灰基质具有良好的保水性能;养分含量在不同层位存在较大差异,粉煤灰复垦地速效氮、速效钾含量从H1至H6层呈现减少后增加的空间分布特征,在H3层处达到最小值16.23mg·kg-1、158.97mg·kg-1,复垦地各层位的速效氮含量均低于对照地块、速效钾含量均高于对照地块;复垦地与对照地块的速效磷含量均呈现先减少后增加再减少的空间分布特征,最大有效磷含量分别为10.01mg·kg-1、11.91mg·kg-1。对比土壤养分分级标准,复垦地土壤中速效氮、速效磷含量均处于缺乏水平,应增施磷肥、氮肥或有机肥以增加土壤养分。粉煤灰复垦地表层土壤和粉煤灰中的Cu、Cr、Pb、Zn、Cd、Ni等元素中Cr、Pb、Zn含量均低于淮南土壤背景值和中国土壤背景值,其中粉煤灰层中各重金属元素均处于土壤环境质量标准的二级范围内,其余各层位重金属元素除Cd均处于土壤环境质量标准的一级范围内;土壤中各重金属元素含量除Zn外均低于粉煤灰中的含量,且粉煤灰层中重金属有向表土迁移的趋势。 | 徐良骥 许善文 杨秀芳 严家平 Helmut Meuser Lutz Makowsky | 2012 | 农业环境科学学报2012，31，12： | 13 |
| 8 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 9 | Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver显示文摘Spontaneous bacterial peritonitis(SBP) is a frequent, life-threatening bacterial infection in patients with liver cirrhosis and ascites. Portal hypertension leads to increased bacterial translocation from the intestine. Failure to eliminate invading pathogens due to immune defects associated with advanced liver disease on the background of genetic predisposition may result in SBP. The efficacy of antibiotic treatment and prophylaxis has declined due to the spread of multi-resistant bacteria. Patients with nosocomial SBP and with prior antibiotictreatment are at a particularly high risk for infection with resistant bacteria. Therefore, it is important to adapt empirical treatment to these risk factors and to the local resistance profile. Rifaximin, an oral, nonabsorbable antibiotic, has been proposed to prevent SBP, but may be useful only in a subset of patients. Since novel antibiotic classes are lacking, we have to develop prophylactic strategies which do not induce bacterial resistance. Farnesoid X receptor agonists may be a candidate, but so far, clinical studies are not available. New diagnostic tests which can be carried out quickly at the patient's site and provide additional prognostic information would be helpful. Furthermore, we need tools to predict antibiotic resistance in order to tailor first-line antibiotic treatment of spontaneous bacterial peritonitis to the individual patient and to reduce mortality. | Philipp Lutz Hans Dieter Nischalke Christian P Strassburg Ulrich Spengler | 2015 | World Journal of Hepatology2015，7，3： | 12 |
| 10 | Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence显示文摘AIM: To investigate biological prevention with flavonoids the recurrence risk of neoplasia was studied in patients with resected colorectal cancer and after adenoma polypectomy. METHODS: Eighty-seven patients, 36 patients with resected colon cancer and 51 patients after polypectomy, were divided into 2 groups: one group was treated with a flavonoid mixture (daily standard dose 20 mg apigenin and 20 mg epigallocathechin-gallat, n = 31) and compared with a matched control group (n = 56). Both groups were observed for 3-4 years by surveillance colonoscopy and by questionnaire. RESULTS: Of 87 patients enrolled in this study, 36 had resected colon cancer and 29 of these patients had surveillance colonoscopy. Among the flavonoid-treated patients with resected colon cancer (n = 14), there was no cancer recurrence and one adenoma developed. In contrast the cancer recurrence rate of the 15 matched untreated controls was 20% (3 of 15) and adenomas evolved in 4 of those patients (27%). The combined recurrence rate for neoplasia was 7% (1 of 14) in the treated patients and 47% (7 of 15) in the controls (P = 0.027). CONCLUSION: Sustained long-term treatment with a flavonoid mixture could reduce the recurrence rate of colon neoplasia in patients with resected colon cancer. | Harald Hoensch Bertram Groh Lutz Edler Wilhelm Kirch | 2008 | World Journal of Gastroenterology2008，14，14： | 12 |
| 11 | 基于图像处理与支持向量机的树上苹果早期估产研究显示文摘为了实现果树挂果期的精准管理,针对树上苹果早期估产问题,以'Gala'苹果为研究对象,开展了对定果后的果树进行产量估测的研究,提出了一种图像处理结合支持向量机的树上苹果早期估产方法。首先在苹果园内获取定果后的果树树冠图像,此时的树上苹果颜色为绿色(本文称此时期为果树青果期);采用分析图像各颜色分量值分布图法,确定在YCb Cr颜色空间中,以Cb≤100与Cr≥120作为分割树冠图像中苹果的条件;从果树树冠图像中提取果实个数、果实面积、果实树叶比、受遮挡果实个数比例及受遮挡果实面积比例;以上述5个特征参数作为输入,实际产量为输出,利用支持向量机方法建立树上苹果早期估产模型。本文利用训练集(含50个样本)训练模型,预测产量与实际产量的决定系数R2达到了0.724 2,均方根误差RMSE为1.71 kg,平均绝对百分比误差MAPE为9%,平均预测误差MFE为0.21。利用测试集(含15个样本)测试模型,得到RMSE为2.45 kg,MAPE为13%。结果表明该模型不仅具有较好的预测精度与无偏性,且具有较好的鲁棒性,所采用的树上苹果早期估产方法可行。 | 程洪 Lutz Damerow Michael Blanke 孙宇瑞 | 2015 | 农业机械学报2015，46，3： | 11 |
| 12 | 中国人口的不确定性研究显示文摘文章对2000年人口普查所反映的生育水平、出生性别比和人口年龄结构等主要人口指标存在的不确定性进行了梳理,并运用概率人口预测方法系统讨论了中国未来人口变动趋势过程中相关人口变量的不确定性问题。结果显示,当前对中国生育率水平、出生性别比和低龄儿童人口数量的估计都存在很大的差异。这些差异直接影响中国人口目前和未来的不确定性。 | 任强 郑晓瑛 Wolfgang Lutz Sergei Scherbov | 2008 | 中国人口科学2008，，6： | 10 |
| 13 | Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy显示文摘Primary ovarian insufficiency(POI)is an ovarian dysfunction that affects more than 1%of women and is characterized by hormone imbalances that afflict women before the age of 40.The typical perimenopausal symptoms result from abnormal levels of sex hormones,especially estrogen.The most prevalent treatment is hormone replacement therapy(HRT),which can relieve symptoms and improve quality of life.However,HRT cannot restore ovarian functions,including secretion,ovulation,and fertility.Recently,as part of a developing field of regenerative medicine,stem cell therapy has been proposed for the treatment of POI.Thus,we recapitulate the literature focusing on the use of stem cells and biomaterials for POI treatment,and sum up the underlying mechanisms of action.A thorough understanding of the work already done can aid in the development of guidelines for future translational applications and clinical trials that aim to cure POI by using regenerative medicine and biomedical engineering strategies. | Sichen Zhang Dashuai Zhu Xuan Mei Zhenhua Li Junlang Li Mengjie Xie Halle Jiang Williams Lutz Shaowei Wang Ke Cheng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 14 | 基于树冠图像特征的苹果园神经网络估产模型显示文摘针对树上苹果产量的早期估测问题,提出了一种利用果树图像树冠树叶与果实的信息,通过BP(Back propagation)神经网络建立模型进行苹果估产的方法。首先在苹果园内分别获取果树在苹果半熟期、成熟期的数字图像,并在苹果收获时将每棵树上的苹果称量,得到实际产量;采用图像处理方法识别出树冠上的果实及树叶;提取果实区域及树叶区域与产量相关的信息为输入,以果树实际产量为输出,建立基于BP神经网络的半熟期与成熟期估产模型,拟合度R分别达到0.928 7、0.980 4。将模型用于待估产样本,得到半熟期样本估测产量与实际产量拟合度R为0.876 6,成熟期样本估测产量与实际产量拟合度R为0.960 6。结果表明该模型具有较好的预测精度与鲁棒性。 | 程洪 Lutz Damerow Michael Blanke 孙宇瑞 程强 | 2015 | 农业机械学报2015，46，1： | 7 |
| 15 | 基于茎直径和茎流复合测量的植物根压无损观测方法显示文摘植物夜间补水依靠根压。根压是研究植物水分生理的重要指标之一,但是根压测量是一个迄今尚未解决的技术难题,尤其是对草本植物,因不允许采用开窗式测量,所以具有更大的技术挑战性。为此探讨了在茎直径与茎流速率复合测量基础上,对Steppe水分存储和流动数学模型作算法换序,实现植物根压的无损动态观测。实验样本选取3株温室茄子,得到了2个独立的、连续5 d的实验数据。结果显示夜间及次日凌晨茄子样本的茎流速率为零,茎直径缓慢增长,此时间段内根压开始出现;晴天时,白天茄子样本蒸腾作用强烈,茎流速率大,茎秆收缩明显,夜间根压增幅较快;阴天时,情况恰好相反,夜间茄子样本根压幅值较小。可见,根压动态均满足茎流速率和茎直径变化的信息解译与气象数据的影响,完全符合已知的植物水分生理调节规律。因此,算法换序对无损观测茄子样本的根压是可行的,可将该方法应用于其他植物根压的无损检测。 | 员玉良 程强 Lutz Damerow 孙宇瑞 | 2015 | 农业机械学报2015，46，11： | 7 |
| 16 | Noninvasive indocyanine green plasma disappearance rate predicts early complications,graft failure or death after liver transplantation显示文摘BACKGROUND:Early detection of graft malfunction or postoperative complications is essential to save patients and organs after orthotopic liver transplantation (OLT).Predictive tests for graft dysfunction are needed to enable earlier implementation of organ-saving interventions following transplantation.This study was undertaken to assess the value of indocyanine green plasma disappearance rates (ICG-PDRs) for predicting postoperative complications,graft dysfunction and patient survival following OLT.METHODS:Eighty-six patients undergoing OLT were included in this single-centre trial.ICG-PDR was assessed daily for the first 7 days following OLT.Endpoints were graft loss or death within 30 days and postoperative complications,graft loss,or death within 30 days.RESULTS:Postoperative complications of 31 patients included deaths (12 patients) or graft losses.ICG-PDR was significantly different in patients whose endpoints were graft loss or death beginning from day 3 and in those whose endpoints were graft loss,death,or postoperative complications beginning from day 4 after OLT.For day 7 measurements,receiver operating characteristic curve analysis revealed an ICG-PDR cut-off for predicting death or graft loss of 9.6% per min (a sensitivity of 75.0%,a specificity of 72.6%,positive predictive value 0.35 negative predictive value 0.94).For prediction of graft loss,death or postoperative complications,the ICG-PDR cut-off was 12.3%per min (a sensitivity of 68.9%,a specificity of 66.7%,positive predictive value 0.57,negative predictive value 0.77).CONCLUSIONS:ICG-PDR measurements on postoperative day 7 are predictive of early patient outcomes following OLT.The added value over that of routinely determined laboratory parameters is low. | Lutz Schneider Martin Spiegel Sebastian Latanowicz Markus A Weigand Jan Schmidt Jens Werner Wolfgang Stremmel Christoph Eisenbach | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 6 |
| 17 | Utility of different glycemic control metrics for optimizing management of diabetes显示文摘The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications, recent studies have revealed that this metric has some limitations; it conveys a rather complex message, which has to be taken into consideration for diabetes screening and treatment. On the basis of recent clinical trials, the relationship between Hb A1 c and cardiovascular outcomes in long-standing diabetes has been called into question. It becomes obvious that other surrogate and biomarkers are needed to better predict cardiovascular diabetes complications and assess efficiency of therapy. Glycated albumin, fructosamin, and 1,5-anhydroglucitol have received growing interest as alternative markers of glycemic control. In addition to measures of hyperglycemia, advanced glucose monitoring methods became available. An indispensible adjunct to Hb A1 c in routine diabetes care is selfmonitoring of blood glucose. This monitoring method is now widely used, as it provides immediate feedback to patients on short-term changes, involving fasting, preprandial, and postprandial glucose levels. Beyond the traditional metrics, glycemic variability has been identified as a predictor of hypoglycemia, and it might also be implicated in the pathogenesis of vascular diabetes complications. Assessment of glycemic variability is thus important, but exact quantification requires frequently sampled glucose measurements. In order to optimize diabetes treatment, there is a need for both key metrics of glycemic control on a day-to-day basis and for more advanced, user-friendly monitoring methods. In addition to traditional discontinuous glucose testing, continuous glucose sensing has become a useful tool to reveal insufficient glycemic management. This new technology is particularly effective in patients with complicated diabetes and provides the opportunity to characterize glucose dynamics. Several continuous glucose monitoring(CGM) systems, which have shown usefulness in clinical practice, are presently on the market. They can broadly be divided into systems providing retrospective or real-time information on glucose patterns. The widespread clinical application of CGM is still hampered by the lack of generallyaccepted measures for assessment of glucose profiles and standardized reporting of glucose data. In this article, we will discuss advantages and limitations of various metrics for glycemic control as well as possibilities for evaluation of glucose data with the special focus on glycemic variability and application of CGM to improve individual diabetes management. | Klaus-Dieter Kohnert Peter Heinke Lutz Vogt Eckhard Salzsieder | 2015 | World Journal of Diabetes2015，6，1： | 6 |
| 18 | Transjugular intrahepatic portosystemic shunt in refractory chylothorax due to liver cirrhosis显示文摘A pleural effusion containing chylomicrons is termed chylothorax and results from leakage of lymph fluid into the pleural cavity.We report on the case of a 59-year-old woman with severe dyspnea due to a large chylothorax.She was known to have liver cirrhosis but no ascites.There was no history of trauma,cardiac function was normal and thorough diagnostic work-up did not reveal any signs of malignancy.In summary,no other etiology of the chylothorax than portal hypertension could be found.Therapy with diuretics as well as parenteral feeding failed to relieve symptoms.After a transjugular intrahepatic portosystemic shunt(TIPS) had successfully been placed,pleural effusion decreased considerably.Eight months later,TIPS revision had to be performed because of stenosis,resulting in remission from chylothorax.This case shows that even in the absence of ascites,chylothorax might be caused by portal hypertension and that TIPS can be an effective treatment option. | Philipp Lutz Holger Strunk Hans Heinz Schild Tilman Sauerbruch | 2013 | World Journal of Gastroenterology2013，19，7： | 6 |
| 19 | 碘化N-正丁基氟哌啶醇对豚鼠心房肌细胞乙酰胆碱敏感性钾通道的影响显示文摘目的研究碘化N正丁基氟哌啶醇(F2)对豚鼠心房肌细胞乙酰胆碱敏感性钾通道(KACh)的影响,探讨其对KACh的作用机制。方法采用膜片钳全细胞记录方法,测定F2对原代培养的豚鼠心房肌细胞乙酰胆碱敏感性钾电流IK(ACh)的影响。结果细胞外给予F2对豚鼠心房肌细胞IK(ACh)呈可逆性、浓度依赖性的阻断作用。细胞内添入抗水解的GTP类似物GTPγS后,结果同前。细胞内给予50μmol·L-1F2对IK(ACh)无作用。结论F2是豚鼠心房肌细胞KACh的一种快速通道阻断剂,发挥作用部位在细胞膜外侧,作用位点在钾通道本身,与乙酰胆碱受体无关。 | 刘冰 石刚刚 高分飞 Lutz Pott | 2005 | 中国药理学通报2005，21，5： | 5 |
| 20 | 充填与非充填开采条件下煤矿沉陷区耕地土壤质量空间分布规律研究显示文摘为了研究煤矿井下充填开采是否能有效保护地表耕地土壤环境,保持土壤肥力,本文以皖北矿业集团公司五沟煤矿充填开采工作面与非充填开采工作面为试验区,在2个工作面对应上方地表分别划分试验区域和对照区域,进行采样、相关土壤指标检测及结果分析。试验区域(充填开采)包括:地表沉陷区坡脚B1处(点1?~点3?)、沉陷区坡面B2处(点4?~点6?)、沉陷区坡顶B3处(点7?~点9?);对照区域(非充填开采)包括:地表沉陷区坡脚A1处(点1~点3)、沉陷区坡面A2处(点4~点6)、沉陷区坡顶A3处(点7~点9)。每个区域分别在9个采样点内按照0~20 cm、20~40 cm和40~60 cm 3个土壤深度分层采集土样,对土壤理化性质以及该区域小麦株高和经济产量进行了测定和分析。试验结果显示,充填开采区域土壤碱解氮、有效磷、速效钾和有机质在3个土层的平均含量均高于非充填开采区域。试验观测期间,3月份B1处小麦株高小于A1处,5—6月B2和B3处小麦长势均优于A2和A3处,直至收割;小麦成熟时,充填开采区域经济产量高于非充填开采区。充填开采区域地块土壤含水量高于非充填开采区域。因此,本文认为充填开采比非充填开采更能保持开采区域上覆土壤的养分和水分。但与正常土壤背景值相比,充填开采区域上覆土壤仍存在某些营养元素(如有机质及磷元素)含量不足的问题,其作为农耕地需要加强人工活动的影响,如增施肥料、加强田间管理等。 | 徐良骥 黄璨 章如芹 严家平 Helmut MEUSER Lutz MAKOWSKY | 2014 | 中国生态农业学报2014，22，6： | 5 |
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