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| 1 | Application research of a novel designed peptide as a potential carrier显示文摘While a great deal of research has focused on the application of full-sequence ionic complementary peptide, detection of the capability of half-sequence ionic complementary peptide such as drug carriers, is rarely reported. This paper presents that the half-sequence ionic complementary peptide P9 (AC-Pro- Ser-Phe-Asn-Phe-Lys-Phe-Glu-Pro-NH2) can successfully stabilize a model hydrophobic drug pyrene in the aqueous solution. Soybean lecithin vesicles were used to mimic plasma membranes. Fluorescence data show that the pyrene is presented in the crystalline form when stabilized by P9 solution, and molecularly migrated from its peptide encapsulations into the membrane bilayers when the suspension is mixed with lipidosome vesicles. Slower release was observed when thicker coating was applied onto pyrene, which could be to control the wall thickness coating the cargo, and consequently the release rate. The result indicated that P9, with half-sequence ionic complement, may serve as a hydrophobic compounds carrier. | RUAN LiPing ZHANG HangYu LUO HanLin ZHAO XiaoJun | 2009 | Science China Chemistry2009，52，5： | 4 |
| 2 | Effect of Sonication on a Novel Designed Peptide显示文摘The reassembly of a half-sequence ionic self-complementarity peptide CH3CO-Pro-Ser-Phe-Cys-Phe-Lys-Phe-Glu-Pro-NH2 was reported, which could self-assemble into stable nanofibers and formed hydrogel consisting of >99% water. In this study, the nanofiber scaffold was sonicated by an ultrasonic cell disruptor. The effects of sonication were detected by circular dichroism (CD), atomic force microscopy (AFM), and rheology. AFM image illustrated that the sonicated fragments could quickly reassemble into nanofibers, while the morphology was distinguishable from the original one. CD spectrum revealed that the conversion occurred mainly between regular β-strand structure and distorted β-strand structure. Rheological analyses showed that the storage modulus (G') of the peptide solution at the 7th day after sonication decreased by nearly 40% compared with the value of the solution before sonication. Finally, a plausible conversion model was proposed to interpret the reassembly process. | 阮丽萍 LUO Hanlin ZHANG Hangyu XING Zhihua | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，3： | 2 |
| 3 | Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift显示文摘Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate rocks.The results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate rocks.Firstly,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study area.Secondly,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic strata.From NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic strata.In profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type faults.In plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal direction.Among them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weakest.This fault activity can be divided into four periods:Sinian,Cambrian-Permian,the early Indosinian period and the late Indosinian-Himalayan period,the transtensional strikeslip faults being the products of oblique extensions of pre-existing weak zones in the Xingkai and Emei taphrogenesis,with a particular inheritance in the main faults.(4)Combined with hydrocarbon accumulation factors,it is considered that the epigenetic karstification of the Tongwan and Caledonian unconformities in the northern slope controlled the formation and distribution of carbonate karst reservoirs over a large area,also acting as a good pathway for oil and gas migration.The extensional faults developed at the margin of the NS trending rift,controlling the sag-platform sedimentary pattern in the Dengying Formation of the Sinian.Strike-slip faults in NE,WNW and ENE directions may control the microgeomorphological pattern inside the platform and intensify the differential distribution of grain beach facies.The multi-stage hereditary activity of strike-slip faults not only improved the porosity and permeability of the reservoirs,but also acted as the main channel of oil and gas migration,providing favorable conditions for the development of the current multi-layer gasbearing scenario in the northern slope of the Central Sichuan Basin. | TIAN Xingwang LIU Guangdi LUO Bing YANG Yu WEN Long ZHANG Benjian CHEN Xiao SU Guiping SONG Zezhang PENG Hanlin ZHOU Gang YAN Wei YANG Dailin WANG Yunlong SUN Yiting DOU Shuang | 2022 | Acta Geologica Sinica(English Edition)2022，96，4： | 2 |
| 4 | Temperature and pH effects on biophysical and morphological properties of self-assembling peptide RADA16-I显示文摘 | Ye Zhaoyang Zhang Hangyu Luo Hanlin | 2008 | J Peptide Sci2008，14，2： | 1 |
| 5 | Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo显示文摘HMG-CoA reductase(HMGCR) protein is usually upregulated after statin(HMGCR inhibitor) treatment, which inevitably diminishes its therapeutic efficacy, provoking the need for higher doses associated with adverse effects. The proteolysis targeting chimera(PROTAC) technology has recently emerged as a powerful approach for inducing protein degradation. Nonetheless, due to their bifunctional nature, developing orally bioavailable PROTACs remains a great challenge. Herein, we identified a powerful HMGCR-targeted PROTAC(21 c) comprising a VHL ligand conjugated to lovastatin acid that potently degrades HMGCR in Insig-silenced HepG2 cells(DC50 Z 120 nmol/L) and forms a stable ternary complex, as predicated by a holistic modeling protocol. Most importantly, oral administration of the corresponding lactone 21 b reveled favorable plasma exposures referring to both the parent 21 b and the conversed acid 21 c. Further in vivo studies of 21 b demonstrated robust HMGCR degradation and potent cholesterol reduction in mice with diet-induced hypercholesterolemia, highlighting a promising strategy for treating hyperlipidemia and associated diseases. | Guoshun Luo Zhenbang Li Xin Lin Xinyu Li Yu Chen Kun Xi Maoxu Xiao Hanlin Wei Lizhe Zhu Hua Xiang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 1 |
| 6 | Stretchable and anti-impact iontronic pressure sensor with an ultrabroad linear range for biophysical monitoring and deep learning-aided knee rehabilitation显示文摘Monitoring biophysical signals such as body or organ movements and other physical phenomena is necessary for patient rehabilitation.However,stretchable flexible pressure sensors with high sensitivity and a broad range that can meet these requirements are still lacking.Herein,we successfully monitored various vital biophysical features and implemented in-sensor dynamic deep learning for knee rehabilitation using an ultrabroad linear range and highsensitivity stretchable iontronic pressure sensor(SIPS).We optimized the topological structure and material composition of the electrode to build a fully stretching on-skin sensor.The high sensitivity(12.43 kPa^(−1)),ultrabroad linear sensing range(1 MPa),high pressure resolution(6.4 Pa),long-term durability(no decay after 12000 cycles),and excellent stretchability(up to 20%)allow the sensor to maintain operating stability,even in emergency cases with a high sudden impact force(near 1 MPa)applied to the sensor.As a practical demonstration,the SIPS can positively track biophysical signals such as pulse waves,muscle movements,and plantar pressure.Importantly,with the help of a neuro-inspired fully convolutional network algorithm,the SIPS can accurately predict knee joint postures for better rehabilitation after orthopedic surgery.Our SIPS has potential as a promising candidate for wearable electronics and artificial intelligent medical engineering owing to its unique high signal-to-noise ratio and ultrabroad linear range. | Hongcheng Xu Libo Gao Haitao Zhao Hanlin Huang Yuejiao Wang Gang Chen Yuxin Qin Ningjuan Zhao Dandan Xu Ling Duan Xuan Li Siyu Li Zhongbao Luo Weidong Wang Yang Lu | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
| 7 | Ductile and high strength Cu fabricated by solid-state cold spray additive manufacturing显示文摘In this work,pure Cu with excellent strength and ductility(UTS of 271 MPa,elongation to fracture of 43.5%,uniform elongation of 30%)was prepared using cold spray additive manufacturing(CSAM),realizing a breakthrough in the field.An in-depth investigation was conducted to reveal the microstructure evolution,strengthening and ductilization mechanisms of the CSAM Cu,as well as the single splats.The results show that the CSAM Cu possesses a unique heterogeneous microstructure with a bimodal grain structure and extensive infinitely circulating ring-mounted distribution of twinning.Based on the single splat observation,the entire copper particle forms a gradient nano-grained(GNG)structure after high-speed impact deposition.The GNG-structured single splat serves as a unit to build the heterogeneous microstructure with bimodal grain distribution during the successive deposition in CSAM.The results also show that CSAM can achieve synergistic strengthening and ductilization by controlling the grain refinement and dislocation density.This work provides potential for CSAM technique in manufacturing various metallic parts with the desired combination of high strength and good ductility without additional post-treatments. | Chaoyue Chen Yingchun Xie Shuo Yin Wenya Li Xiaotao Luo Xinliang Xie Ruixin Zhao Chunming Deng Jiang Wang Hanlin Liao Min Liu Zhongming Ren | 2023 | Journal of Materials Science & Technology2023，，3： | 0 |
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