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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | 膳食硝酸盐通过减少交感神经过度激活的机制降低血管紧张素Ⅱ诱导的高血压大鼠的血压显示文摘几项实验和临床研究表明,膳食中添加硝酸盐可提高一氧化氮的生物利用度。在口腔中,共生细菌将硝酸盐还原成亚硝酸盐,其随后被吸收到循环中,通过酶系统还原为一氧化氮。已知增加硝酸盐-亚硝酸盐-一氧化氮途径可以改善心血管、肾脏和代谢功能,并且交感神经兴奋有助于疾病的进展,但是膳食硝酸盐对交感神经活动的潜在影响仍有待阐明。 | 刘莉 叶鹏 ■ DD Cruz JC ■ A Zhuge Z Marques SM Naves LM Persson AEG Weitzberg E Lundberg JO Balarini CM Pedrino GR Braga VA ■ M | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 3 | Spelenthems and climate:a special issue of the Holocene显示文摘 | Lundberg J | 1999 | The Holocene1999，9，6： | 1 |
| 4 | Survival,integration,and differentiation of neural stem cell lines after transplantation to the adult rat striatum显示文摘 | Lundberg C Martinez-Serrano A Cattaneo E | 1997 | Exp Neurol1997，145，： | 1 |
| 5 | Nitrate, bacteria and human health 显示文摘 | Lundberg J O Weitzberg E Cole J A | 2004 | Nature Reviews Microbiology2004，2，7： | 1 |
| 6 | Separation of lipid classes from marine particulate material by HPLC on a polyvinyl alcohol-bonded stationary phase using dual-channel evaporative light-scattering detection 显示文摘 | Nordback J Lundberg E Christie W W | 1998 | Marine Chemistry1998，60，： | 1 |
| 7 | Increased amount of nitric oxidein exhaled air of asthmatics显示文摘 | Alving K Weitzberg E Lundberg J M | 1993 | Eur Respir 11993，6，9： | 1 |
| 8 | Cooperation among Companies,Universities and Local Government in a Swedish Context 显示文摘 | Lundberg H E Andresen | 2012 | Industrial Marketing Management2012，41，3： | 1 |
| 9 | Allergenic cross-reactivity between the nematode Anisakis simplex and the dust mites Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae, and Dermatophagoides pteronyssinus 显示文摘 | Johansson E Aponno M Lundberg M | 2001 | Allergy2001，56，7： | 1 |
| 10 | Increased amount of nitric oxide in exhaled air of asthmatics显示文摘 | Alving K Weitzberg E Lundberg JM | | 0，，09： | 1 |
| 11 | Increased amount of nitric oxide in exhaled air of asthmatics显示文摘 | Alving K Weitzberg E Lundberg JM | 1993 | Eur Respir J1993，6，9： | 1 |
| 12 | Advantages and dis- advantages of peripherally inserted central venous catheters ( PICC ) compared to other central venous lines: a systematic review of the liter- ature显示文摘 | Johansson E Hammarskjld F Lundberg D | 2013 | Acta Oncol2013，52，5： | 1 |
| 13 | The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics显示文摘 | Lundberg JO Weitzberg E Gladwin MT | 2008 | Nat Rev Drug Discov2008，7，： | 1 |
| 14 | Autoerine growth factors in human periodontal ligament ceils cultured on enamel matrix derivative显示文摘 | Lyngstadaas SP Lundberg E Ekdahl H | 2001 | J Clin Periodontol2001，28，： | 1 |
| 15 | The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics显示文摘 | LUNDBERG J O WEITZBERG E GLADWIN MT | 2008 | Nat Rev Drug Discov2008，7，： | 1 |
| 16 | Selective tissue accumulation of manganese and its effect on regional blood flow and haemodynamics after intravenous infusion of its chloride salt in the rat 显示文摘 | Gerdin B McCann E Lundberg C | 1985 | Int J Tissue React1985，7，3： | 1 |
| 17 | Increased amount of nitricoxide in exhaled air of asthmatics 显示文摘 | Alving K Weitzberg E Lundberg JM | 1993 | Eur Respir J1993，6，9： | 1 |
| 18 | Inhibition of hormone and cytokine stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased OPG and decreased RANKL and RANK in a STAT6 dependent pathway显示文摘 | Palmqvist P Lundberg P Persson E | 2006 | J Biol Chem2006，281，5： | 1 |
| 19 | Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway显示文摘 | Palmqvist P Lundberg P Persson E | 2006 | J Biol Chem2006，281，5： | 1 |
| 20 | Advanta- ges and disadvantages of peripherally inserted central ve- nous catheters (PICC) compared to other central venous lines : a systematic review of the literature 显示文摘 | Johansson E Hammarskjold F Lundberg D | 2013 | Acta Oncol2013，52，5： | 1 |
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