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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Researching mouth care in the ICU显示文摘 | Holberton P Liggett G Lundberg D | 1996 | Can Nurse1996，92，5： | 1 |
| 3 | Structure relations alone the margins of the offshore Taiwan accretionary wedge: implications for accretion and crustal kinematics显示文摘 | Reed D L Lundberg N Liu C S | 1992 | Acta Geologica Taiwaniea1992，30，105： | 1 |
| 4 | p53Activation following Rift Valley Fever Virus Infection Contributes to Cell Death and Viral Production显示文摘 | Austin D Baer A Lundberg L | 2012 | PLoS One2012，7，36： | 1 |
| 5 | Advantages and dis- advantages of peripherally inserted central venous catheters ( PICC ) compared to other central venous lines: a systematic review of the liter- ature显示文摘 | Johansson E Hammarskjld F Lundberg D | 2013 | Acta Oncol2013，52，5： | 1 |
| 6 | Assessing, controlling, and assuring the quality of medical information on the Internet: Caveant lector et viewor--Let the reader and viewer beware显示文摘 | Silberg W M Lundberg G D Musacchio R A | 1997 | Jama the Journal of the American Medical Association1997，277，15： | 1 |
| 7 | Preparation of calcium alginate nanoparticles using water-in-oil ( W/O ) nanoemulsions 显示文摘 | Machado AHE Lundberg D Ribeiro A J | 2012 | Langmuir: the ACS Journal of Surfaces and Colloids2012，28，9： | 1 |
| 8 | Intensive care syndrome:A literature review显示文摘 | Granberg A Engberg IB Lundberg D | 1996 | Intensive Crit Care Nurs1996，12，： | 1 |
| 9 | Stressful memo- ties and psychological distress in adult mechanically ventila- ted intensive care patients-a 2-month follow-up study 显示文摘 | Samuelson K A Lundberg D Fridlund B | 2007 | Acta Anaesthesiol Scand2007，51，6： | 1 |
| 10 | Advanta- ges and disadvantages of peripherally inserted central ve- nous catheters (PICC) compared to other central venous lines : a systematic review of the literature 显示文摘 | Johansson E Hammarskjold F Lundberg D | 2013 | Acta Oncol2013，52，5： | 1 |
| 11 | Structural relations along the margins of the offshore Taiwan accretionary wedge:implications for accretion and crustal kinematics显示文摘 | Reed D L Lundberg N Liu C S Kuo B Y | 1992 | Acta Geologica Taiwanica1992，30，： | 1 |
| 12 | Intensive care syndrome: a literature review显示文摘 | Granberg A Engberg IB Lundberg D | 1996 | Intensive Crit Care Nurs1996，12，3： | 1 |
| 13 | Generation of oligodendroglial progenitors from neural stem cells显示文摘 | Zhang SC Lundberg C Lipsitz D | | 0，，07： | 1 |
| 14 | Preparation of an ionomer elastomer by continuous sulfonation in an extruder and neutralization in static mixers显示文摘 | Siadat R Lundberg R D Lenz R W | 1980 | Polym Eng Sci1980，20，： | 1 |
| 15 | Increased plasma levels of natriuretic peptide type B and A in children with congenital heart defects with left compared with right ventricular volume overload or pressure overload显示文摘 | Westerlind A Lundberg P | 2005 | Clin Physiol Funct Imaging2005，25，5： | 1 |
| 16 | Stressful memories and psychological distress in adult mechanically ventilated intensive care patients - a 2-month follow-up study显示文摘 | Samuelson KA Lundberg D Fridlund B | 2007 | Acta Anaesthesiol Scand2007，51，6： | 1 |
| 17 | Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain显示文摘 | LUNDBERG C ENGLUND U TRONO D | 2002 | Exp Neurol2002，175，2： | 1 |
| 18 | A new look in social tourism显示文摘 | Lundberg D | 1972 | Cornell Hotel and Restaurant Administration Quarterly1972，，13： | 1 |
| 19 | A survey of the current use of peripherally inserted central venous catheter (PICC) in Swedish oncology departments 显示文摘 | Johansson E Hammarskjold F Lundberg D | 2013 | Acta Oncol2013，52，6： | 1 |
| 20 | Photoluminescence imaging of speleothem microbanding with a high-resolution confocal scanning laser macroscope 显示文摘 | Ribes A Lundberg J Waldron D | 2000 | Quaternary International2000，6871，： | 1 |
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