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| 1 | Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects显示文摘AIM: To establish an association between the serum leptin levels and the development of gallstone disease (GD).METHODS: We carried out a non-matched case-controlled study in a university hospital in Mexico City. Two hundred and eighty-seven subjects were included: 97 cases with gallstones and 190 controls. Body mass index (BMI), fasting plasma leptin, insulin, serum lipid, and lipoprotein levels were measured. Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Unconditional logistic regression analysis (univariate and multivariate)stratified by BMI was used to calculate the risk of GD.RESULTS: The multivariate conditional regression analysis revealed a model for those patients with BMI <30. The selected variables in the model were HOMA-IR index with OR = 1.31, P= 0.02 and leptin higher than median with OR = 2.11, P= 0.05. In the stratum of BMI ≥30, we did not find a useful model.CONCLUSION: We concluded that insulin resistance and the development of GD appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles. | Nahum Méndez-Sánchez Luisa B Bermejo-Martínez Yolanda Vi(n|~)als Norberto C Chavez-Tapia Irina Vander Graff Guadalupe Ponciano-Rodríguez Martha H Ramos Misael Uribe | 2005 | World Journal of Gastroenterology2005，11，39： | 11 |
| 2 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 3 | Normal pressure hydrocephalus: a qualitative study on outcome显示文摘 | Paulo B Luisa A Olga R | 2013 | Arq Neuropsiquiatr2013，71，： | 1 |
| 4 | Review on thermal energy storage with phase change:materials,heat transfer analysis and applications显示文摘 | MARIN J M LUISA F | 2003 | Applied Thermal Engineering2003，23，： | 1 |
| 5 | Antioxidant activities of sicilian prickly pear(opuntia ficus indica)fruit extracts and re ducing properties of its betalains: betanin and indicaxanthin显示文摘 | Daniela B Luisa T Francesca D G | 2002 | Agricultural and Food Chemistry2002，50，23： | 1 |
| 6 | Thrombotic microangiopathy associated with parvovirus B19 infection after renal transplantation显示文摘 | Luisa M Graziella Z Daniela B | 2000 | J Am Soc Nephrol2000，11，： | 1 |
| 7 | Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: biological and clinical result 显示文摘 | FEDERICO C LUISA B ELISA F | 2005 | Cancer Gene Therapy2005，12，： | 1 |
| 8 | Prevalence and natural history of adrenal incidentalomas显示文摘 | Nicoletta S Francesco F | 2003 | Eur J Endocrinol2003，149，4： | 1 |
| 9 | Intra-inflorescence variation in floral traits and reproductive success of the hermaphrodite Silene acutifolia显示文摘 | Luisa B M | 2004 | Annals of Botany2004，94，： | 1 |
| 10 | Primary angiosarcoma of the pericardium:case report and review of the literature显示文摘 | ANA T LUISA M IVAN B | 2010 | Kardiol Pol2010，68，7： | 1 |
| 11 | Review on thermal energy storage with phase change materials:Heat transfer analysis and applications显示文摘 | Zalba B Marin J M Luisa F | 2003 | Appl Therm Eng2003，23，： | 1 |
| 12 | An analysis of e- business adoption and its impact on relational quality in travel agency-supplier relationships 显示文摘 | LUISA A JOAQUIN A J E B | 2010 | Tourism Management2010，31，6： | 1 |
| 13 | Altered T cell costimulation during chronic hepatitis B infection 显示文摘 | Luisa B Siham S Darrell L | 2009 | Cellular Immunology2009，257，12： | 1 |
| 14 | Fungal and plant gene expression in ar- buscular myeorrhizal symbiosis显示文摘 | Raffaella B Luisa L | 2006 | Mycorrhiza2006，16，8： | 1 |
| 15 | Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae显示文摘 | PAOLA F LUISA B RAFFAELLO V | 2004 | Journal ofCellBiology2004，166，7： | 1 |
| 16 | Mimotopes of nicotinic receptor binding site selected by a combinatorial peptide library显示文摘 | LUISA B LUISA L LELLI B | 2001 | Biochemistry2001，40，： | 1 |
| 17 | Comparative analysis of 8 - oxoG: C, 8 - oxoG: A, A: C and C: C DNA repair in ex- tracts from wild type or 8 -oxoG DNA glycosylase deficient mammalian and bacterial ceils 显示文摘 | Francoise D Magnar B Luisa L | 2003 | DNA Repair2003，2，6： | 1 |
| 18 | Dendritic cell-specific antigen delivery by coronavirus vaccine vectors induces long-lasting protective antiviral and an- titumor immunity显示文摘 | Luisa C B Roland Z Reinhard M | 2010 | MBIO2010，1，4： | 1 |
| 19 | Management of hepatitis C 显示文摘 | Alberti A Luisa B | 2003 | J Hepatology2003，38，： | 1 |
| 20 | Long-term follow-up of children undergoing topical intranasal steroid therapy for adenoidal Hypertrophy显示文摘 | Marco B Luisa V Giovanni P | 2008 | International Journal of Pediatric Otorhino￣laryngology2008，72，3： | 1 |
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