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| 1 | Characterisation of human non-proliferative diabetic retinopathy using the fractal analysis显示文摘· AIM: To investigate and quantify changes in the branching patterns of the retina vascular network in diabetes using the fractal analysis method.·METHODS: This was a clinic-based prospective study of 172 participants managed at the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and December 2013. A set of 172 segmented and skeletonized human retinal images, corresponding to both normal(24 images) and pathological(148 images)states of the retina were examined. An automatic unsupervised method for retinal vessel segmentation was applied before fractal analysis. The fractal analyses of the retinal digital images were performed using the fractal analysis software Image J. Statistical analyses were performed for these groups using Microsoft Office Excel2003 and Graph Pad In Stat software.·RESULTS: It was found that subtle changes in the vascular network geometry of the human retina are influenced by diabetic retinopathy(DR) and can be estimated using the fractal geometry. The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is slightly lower than the corresponding values of mild non-proliferative DR(NPDR) images(segmented and skeletonized versions).The average of fractal dimensions D for the normal images(segmented and skeletonized versions) is higher than the corresponding values of moderate NPDR images(segmented and skeletonized versions). The lowestvalues were found for the corresponding values of severe NPDR images(segmented and skeletonized versions).· CONCLUSION: The fractal analysis of fundus photographs may be used for a more complete understanding of the early and basic pathophysiological mechanisms of diabetes. The architecture of the retinal microvasculature in diabetes can be quantitative quantified by means of the fractal dimension.Microvascular abnormalities on retinal imaging may elucidate early mechanistic pathways for microvascular complications and distinguish patients with DR from healthy individuals. | Stefan Tǎlu Dan Mihai Cǎlugǎru Carmen Alina Lupascu | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 4 |
| 2 | Experimental Determination of Automotive System Response Characteristics, Automotive Engineering International显示文摘 | ZHEN J T LIM T C LUG O | 2001 | Journal of Passenger Cars: Mechanical System2001，，6： | 1 |
| 3 | Partial liquid ventilation confers protection against acute lung injury induced by endotoxin in juvenile piglets显示文摘 | GUO Z L LUG P REN T | 2009 | Respir Physiol Neurobiol2009，167，3： | 1 |
| 4 | Experimental Determination of Automotive System Response Characteristics显示文摘 | ZHEN J LIM T C LUG Q | 2001 | Journal of Passenger Cars: Mechanical Systems2001，110，6： | 1 |
| 5 | Photocatalysis on TiO2 surfaces:Principles,mechanisms,and selected results显示文摘 | LINSEBIGLER A L LUG Q YATES J T | 1995 | Chem Rev1995，95，3： | 1 |
| 6 | Determination of System Vibrato- ry Response Characteristics Applying a Spectral-based In- verse Sub-structuring Approach显示文摘 | ZHEN J LIM T C LUG Q | 2004 | International Journal Ve- hicle Noise and Vibration2004，1，12： | 1 |
| 7 | Experimental Determination of Automotive System Response Characteristics, Automotive Engineering International显示文摘 | ZHEN J T LIM T C LUG Q | 2001 | Journal of Passenger Cars: Mechanical System2001，110，6： | 1 |
| 8 | Simultaneous multichannel wavelength multicasting and XOR logic gate multicasting for three DPSK signals based on four-wave mixing in quantum-dot semiconductor optical amplifier显示文摘 | QIN J LUG W SAKAMOTO T | 2014 | Optics Express2014，22，29： | 1 |
| 9 | A novel locus involved in extracellular polysaccharide production and virulence of Xanthomonas campestris pathovar campestris 显示文摘 | LUG T MA Z F HU J R | 2007 | Microbiol2007，153，3： | 1 |
| 10 | Photocatalysis on TiO2 surfaces : principles, mechanisms, and selected results 显示文摘 | LINSEBIGLER A L LUG Q YATES J T | 1995 | Chemical Review1995，95，3： | 1 |
| 11 | Transverse blast loading of hollow beams with square cross- sections 显示文摘 | KARAGIOZOVA D YU T X LUG | 2013 | Thin-Walled Structures2013，62，： | 1 |
| 12 | Photocatalysis on TiO2 surfaces: Principles, mechanisms, and selected results显示文摘 | LINSEBIGLER A L LUG Q YATES J T | 1995 | Chem Rev1995，95，3： | 1 |
| 13 | Experimental study and numerical simulation of pipe-on-pipe impact 显示文摘 | YANG J L LUG Y YU T X | 2009 | International Journal of Impact Engineering2009，36，1011： | 1 |
| 14 | A study on type Ⅱ structures part Ⅰ:a modified one-dimensional mass-spring model显示文摘 | GAO Z Y YU T X LUG X | 2004 | Int J Impact Eng2004，4，： | 1 |
| 15 | Kinetics of AlOOH dissolving in caustic solution studiedby high-pressure DSC显示文摘 | BAO L ZHANG T A DOU Z H LUG Z GUO Y N NI P Y WU X J MA J | 2011 | Trans Nonferrous Met Soc China2011，21，1： | 1 |
| 16 | Photocatalysis on TiO2 surfaces: principles, mechanisms, and selected results 显示文摘 | LINSEBIGLER A L LUG Q YATES J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 17 | Optical phase erasure based on FWM in HNLF enabling format conversion from 320-Gb/s RZD-QPSK to 160-Gb/s RZ-DPSK 显示文摘 | LUG W MIYAZAKI T | 2009 | Optics Express2009，17，13： | 1 |
| 18 | Photocatalysis on TiO2surfaces:principles,mechanisms and selected results显示文摘 | LINSEBIGLER A L LUG Q YATES J T | 1995 | Chem Rev1995，95，3： | 1 |
| 19 | Photocatalysis on TiO^2 surfaces: Principles, mechanisms, and selected results 显示文摘 | LINSEBIGLER A L LUG Q YATES J T | 1995 | Chem Rev1995，95，： | 1 |
| 20 | Experimental Determination of Automotive System Response Characteristics显示文摘 | ZHEN J LIM T C LUG Q | 2001 | Journal of Passenger Cars: Mechanical Systems2001，110，6： | 1 |
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