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		题名	作者	年代	出处	被引量
	1	High passage numbers induce resistance to apoptosis in C2C12muscle cells显示文摘Cell lines with high passage numbers exhibit alterations in cell morphology and functions.In thepresent work,C2C12 skeletal muscle cells with either low(<20)or high(>60)passage numbers(identified as l-C2C12 or h-C2C12,respectively)were used to investigate the apoptotic response to H2O2 as a function ofculture age h-C2C12.We found that older cultures(h-C2C12 group)were depleted of mitochondrial DNA(mtDNA).When we analyzed the behavior of Bad,Bax,caspase-3 and mitochondrial transmembrane potential,we observed that cells in the h-C2C12 group were resistant to H2O2 induction of apoptosis.We propose seriallycultured C2C12 cells as a refractory model to H2O2-induced apoptosis.In addition,the data obtained in thiswork suggest that mtDNA is required for apoptotic cell death in skeletal muscle C2C12 cells.	LUCIA PRONSATO ANABELA LA COLLA ANA CAROLINA RONDA LORENA MILANESI RICARDOBOLAND ANDREA VASCONSUELO	2013	BIOCELL2013，37，1：	0

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