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| 1 | Banxia Xiexin Decoction(半夏泻心汤)Treats Diabetic Gastroparesis through PLC-IP3-Ca^2+/NO-cGMP-PKG Signal Pathway显示文摘Objective To test the effect of Banxia Xiexin Decoction(半夏泻心汤,BXD)on the contraction and relaxation of gastric smooth muscle(SM)in diabetic gastroparesis(DGP)model rats,and to explore the mechanism of BXD in the prevention and treatment of DGP through experiments of signal pathway both in vivo and in vitro.Methods Sixty Sprague-Dawley rats were divided into 6 groups according to a random number table:control group,model group,high-,medium-and low-dose BXD groups(9.2,4.6 and 1.8 g/(kg·d),respectively),and domperidone group(10 mg/(kg·d)),10 rats per group.DGP model was established initially by a single intraperitoneal injection of streptozotocin(STZ),and was confirmed by recording gastric emptying,intestinal transport velocity and gastric myoelectric activity of rats after 2 months.Each group was treated with a corresponding drug for 4 weeks.The mRNA and protein expressions of phospholipase C(PLC),inositol triphosphate(IP3),neuronal nitric oxide synthase(nNOS),and cyclic guanosine monophosphate(cGMP)dependent protein kinase G(PKG)were detected by reverse transcription-polymerase chain reaction and Western blot,respectively,while nitric oxide(NO)and cGMP expressions were detected by enzyme-linked immunosorbent assay.Gastric tissues were obtained from rats for primary cell culture preparation.Gastric SM cells were treated with 0.8µmol/L of STZ or STZ plus 1,000,500 and 200µg/mL of BXD or STZ plus 2.5µmol/mL of domperidone for 24,48,72 or 96 h,respectively.The length of gastric SM cells and intracellular Ca^2+concentration([Ca^2+]i)before and after BXD treatment was measured.Results Compared with the model group,high-and medium-dose BXD and domperidone significantly increased the expressions of PLC,IP3,NO,nNOS,cGMP and PKG in rat’s gastric tissue(P<0.01).Gastric SM cells treated with BXD showed a time-and dose-dependent increase in cell viability(P<0.01).The treatment with high-and medium-dose BXD and domperidone inhibited the increase in gastric SM cells length and increased[Ca^2+]i compared with the model cells(P<0.01).Conclusions Treatment with high-and medium-dose BXD significantly attenuated STZ-induced experimental DGP in rats.The therapeutic effect of BXD on DGP rats might be associated with the PLC-IP3-Ca^2+/NO-cGMP-PKG signal pathway. | WANG Bin ZENG Ke-wu HONG Zi-fu Tl Gui-xiang WANG Li-yun LU Pin LIU Zhen | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 8 |
| 2 | Effects of Zr on Microstructure and Short-TermStrength in GH586显示文摘0.020, 0.045 and 0.075 wt pct Zr were added to a Ni-base superalloy GH586 to investigate theirefFects on the microstructure and the short-term strengths at 850℃. The results showed thatproper Zr addition could improve the alloy tensile strength at 850℃ and short-term rupture life at850℃, 580 MPa. Zr exists in both γ’ phase and γ matrix, which caused Zr to distribute in graininstead of segregating in grain boundaries, therefore increased both of their lattice parametersbut decreased the mismatch between them. Meanwhile, it also increased the amount of grain-boundary carbides and decreased their size markedly. These contributed to the improvement ofshort-term rupture life. However, further addition of Zr resulted in forming Zr4C2S2, a plate-fike stable sulphurocarbides in grain boundaries, which decreased short-term strength at hightemperature, and led to a worse hot workability. According to the experimental results, theoptimum content of Zr should be 0.020 wt pct. | Xie, SS Wang, TL Lu, JY Yang, HC Zhao, GP | 1999 | Journal of Materials Science & Technology1999，15，5： | 3 |
| 3 | Assessment of liver tumor response by high-field (3 T) MRIafter radiofrequency ablation:short-and midterm evolution of diffusion parameters within the ablation zone显示文摘 | Lu TL Becce F Bize P | 2012 | Eur J Radiol2012，81，9： | 1 |
| 4 | Expression of c-fos protein in sugstance Precetor-like immunoreactive neurons in response to noxious stimuli on the urrnry bladder:an observation in the lunbosacral cord segments of the rat显示文摘 | Lu Yan Jin SX Xu TL | | 0，，： | 1 |
| 5 | Conditionally ablated ptenin prostate basal cells promotes basal-to-luminal differentiation and causes invasive peostate cancer in mice显示文摘 | Lu TL Huang YF You LR | 2013 | Am J Pathol2013，182，： | 1 |
| 6 | Clozapine for blephamspasm, obsess-ive-compulsive symptoms, and psychotic symptoms in a patient of old brain infarction 显示文摘 | Sun CH Lu CH Huang TL | 2006 | Clin Neuropharmacol2006，29，： | 1 |
| 7 | The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons显示文摘 | Lu H Xu TL | 2002 | J Biol Chem2002，277，41： | 1 |
| 8 | Smoking and alcohol drinking in relation to risk of gastric cancer:a population- based,prospective cohort study 显示文摘 | Sjodahl K Lu Y Nilsen Tl | 2007 | Int J Cancer2007，120，1： | 1 |
| 9 | Ascending aorta measurements as assessed by ECG-gated multi-detector computed tomography: a pilot study to establish normative values for transcatheter therapies 显示文摘 | Lu TL Huber CH Rizzo E | 2009 | Eur Radiol2009，19，： | 1 |
| 10 | Disease burden and related medical costs of rotavirus infections in Taiwan 显示文摘 | Lu CY Lauderdale TL Fang YH | 2006 | BMC Infect Dis2006，6，： | 1 |
| 11 | Biliary complications and management in pediatric living donor liver transplantation for un- derlying biliary atresia 显示文摘 | Lu CH Tsang LLC Huang TL | 2012 | Transplant Proc2012，44，2： | 1 |
| 12 | The dose-response pharmaeology of intrathecal sufentanil in female volunteers 显示文摘 | Lu JK Schafer PG Gardner TL | 1997 | Anesth Analg1997，85，： | 1 |
| 13 | Expression of c-fos protein in substance P receptor-like immunoreactive neurons in response to noxious stimuli in the urinary bladder:an observation in the lumbosacral cord segments of the rat 显示文摘 | Lu Y Jin SX Xu TL | 1995 | Neurosci Lett1995，198，2： | 1 |
| 14 | Inorganic whiskers reinforced bismaleimide composites显示文摘 | Liang GZ Hu XL Lu TL | 2005 | Journal of Materials Science2005，40，7： | 1 |
| 15 | Hispolon from Phellinus linteus has anti- proliferative effects via MDM2 -recruited ERKI/2 activity in breast and bladder cancer ceils 显示文摘 | Lu TL Huang GJ Lu TJ | 2009 | Food Chem Toxico12009，47，8： | 1 |
| 16 | (2012) Laparoscopic complete mesocolic excision (CME) with medial access for right-hemi colon cancer: feasibility and technical strategies 显示文摘 | Feng B Sun J Ling TL Lu AG Wang ML Chert XY Ma JJ Li JW Zang L Harl DP Zheng MH | 2012 | Surg Endosc2012，26，12： | 1 |
| 17 | Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells显示文摘 | LU TL HUANG GJ LU TJ | 2009 | Food Chem Toxicol2009，47，8： | 1 |
| 18 | Conditionally ablated Pten in prostate basal cells promotes basal-to-luminal differentia- tion and causes invasive prostate cancer in mice 显示文摘 | LU TL HUANG YF YOU LR | 2013 | Am J Pathol2013，182，3： | 1 |
| 19 | Smoking and alcohol drinking in relation to risk of gastric cancer:a population- based prospective cohort study 显示文摘 | Sjodahl K Lu Y Nilsen TL | 2007 | Int J Cancer2007，120，1： | 1 |
| 20 | Dissemination of muhidrug- resistant, class I integron-carrying Acinetobacter baurnannii isolates in Taiwan 显示文摘 | Huang LY Chen TL Lu PL | 2008 | Clin Mierobiol Infect2008，14，11： | 1 |
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