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| 1 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 2 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 3 | Does the molecular structure of CaH_2 affect the dihydrogen bonding in CaH_2 HY(Y = CH_3,C_2H_3,C_2 H,CN,and NC) complexes? A quantum chemistry study using MP2 and B3LYP methods显示文摘Second-order M ller-Plesset(MP2) and density functional theory(DFT) calculations have been carried out in order to investigate the structures and properties of dihydrogen-bonded CaH 2 HY(Y = CH 3,C 2 H 3,C 2 H,CN,and NC) complexes.Our calculations revealed two possible structures for CaH 2 in CaH 2 HY complexes:linear(I) and bent(II).The bond lengths,interaction energies,and strengths for H H interactions obtained by both MP2 and B3LYP methods are quite close to each other.It was found that the interaction energy decreases with increasing electron density at the Ca-H bond critical point.Atom-in-molecule(AIM) results show that for all of Ca-H H-Y interactions considered here,the Laplacian of the electron density at the H H bond critical point is positive,indicating the electrostatic nature of these Ca-H H-Y dihydrogen bonded systems. | FENG Lu BAI FuQuan WU Yang ZHANG HongXing | 2012 | Science China Chemistry2012，55，2： | 3 |
| 4 | Production of C60/C70 Ion Beams显示文摘With a 30 keV mini-separator at the accelerator laboratory of Fudan University,we have successfully obtained about 1 nA fullerene ion bea.m.Under the same conditions,we have also observed the fragment ions C_(n)^(+) (n=20-40).The C_(60)^(+) (C_(70)^(+)) beams will be used study collision between fullerene and electrons,atoms and photons. | FANG Dufei GAO Haibin LU Fuquan TANG Jiayong YANG Fujia | 1993 | Chinese Physics Letters1993，10，8： | 0 |
| 5 | Aerosol optical properties and its direct radiative forcing over Tibetan Plateau from 2006 to 2017显示文摘Studies on optical properties of aerosols can reduce the uncertainty for modelling direct radiative forcing(DRF)and improve the accuracy for discussing aerosols effects on the Tibetan Plateau(TP)climate.This study investigated the spatiotemporal variation of aerosol optical and microphysical properties over TP based on OMI and MERRA2,and assessed the influence of aerosol optical properties on DRF at NamCo station(30°46.44′N,90°59.31′E,4730 m)in the central TP from 2006 to 2017 based on a long measurement of AERONET and the modelling of SBDART model.The results show that aerosol optical depth(AOD)exhibits obvious seasonal variation over TP,with higher AOD500nm(>0.75)during spring and summer,and lower value(<0.25)in autumn and winter.The aerosol concentrations show a fluctuated rising from 1980 to 2000,significant increasing from 2000 to 2010 and slight declining trend after 2013.Based on sensitivity experiments,it is found that AOD and single scattering albedo(SSA)have more important impact on the DRF compared withαvalues and ASY.When AOD440nm increases by 60%,DRF at the TOA and ATM is increased by 57.2%and 60.2%,respectively.When SSA440nm increases by 20%,DRF at the TOA and ATM decreases by 121%and 96.7%,respectively. | Hongru Bi Siyu Chen Dan Zhao Fuquan Lu Yu Chen Yawen Guan | 2023 | Particuology2023，，3： | 0 |
| 6 | Absolute Cross Sections for Single Ionization of Ar^(+) and Cl^(+) by Electron Impact显示文摘A crossed-beam facility for electron impact ionization of ions was constructed.The absolute cross sections for single ionization of Ar^(+) and Cl^(+) ions at electron energies ranging from 30 to 500eV were measured.The uncertainty is about±13%. | SHI Wei FANG Dufei LU Fuquan GAO Haibin GU Jian WU Songmao WU Weiming TANG Jiayong YANG Fujia | 1994 | Chinese Physics Letters1994，11，2： | 0 |
| 7 | Effects of Electron Donating Ability of Substituents and Molecular Conjugation on the Electronic Structures of Organic Radicals显示文摘The geometries and electronic structures of a series of electron donor-acceptor radical molecules have been studied theoretically.The computational results show that the introduction of substituents with strong electron donating ability into tri-(2,4,6-trichlorophenyl)methyl(TTM)radicals enables the radical molecules to form the non-Aufbau electronic structure.The difficulty of forming the non-Aufbau electronic structure decreases with the enhancement of the electron donating ability of the substituent,but the expansion of the molecular conjugated system is not conducive to the formation.The hybridization of different fragments in molecular orbitals results in the disproportionation of orbital energy level and forms a staggered energy level structure.The electronic structure of radical molecules can be adjusted by substituents and molecular skeleton profoundly,which is a very effective means for molecular design. | LI Pengyuan FENG Lu LI Guangyue BAI Fuquan | 2023 | Chemical Research in Chinese Universities2023，39，2： | 0 |
| 8 | Single Electron Capture for Impact of Proton on H_(2)显示文摘The cross sections of electron capture for 3-10 keV proton traversing H_(2) were measured by using the‘growth rate’method.The experimental procedure is described.The experimental results are in good agreement with the recommended data. | WU Weimin GU Jian WU Songmao LU Fuquan YANG Fujia | 1994 | Chinese Physics Letters1994，11，8： | 0 |
| 9 | Single Electron Capture for Ce^(+)and Ho^(+)in H_(2)显示文摘The single-electron capture cross sections for the impact of rare-earth ions Ce^(+),Ho^(+)on H_(2)are measured in the energy range 3-8keV by'growth rate'method.The measurement also reveals that the incident ions are predominantly in ground state. | WU Weimin GU Jian WU Songmao LU Fuquan YANG Fujia | 1995 | Chinese Physics Letters1995，12，1： | 0 |
| 10 | OPTICAL ISOTOPE SHIFT MEASUREMENTS USING COLLINEAR ION BEAM LASER SPECTROSCOPY AND THE CONFIGURATION OF THE NdII(23537)_(9/2)^(0) LEVEL显示文摘The optical isotope shifts,of five even isotopes of neodymium have been measured by using collinear ion beam laser spectroscopy(CZBLS).Isotopically pure NdII ions with energy of 30ke V from an isotope separator were collinearly interacted with light from a tunable dye laser and selectively excited from a metastable level of 4f^(4) 5d^(6) K_(9/2) to the(23537)_(9/2)^(0) level by Doppler tuning technique.The resonant excitation frequency values for each Nd isotope with mass number of 142,144,146,148 and 150 were obtained.After the separation of the normal and specific mass shift and the field shift from the experimentally measured isotope shift,the configuration of the(23537)_(9/2)^(0),level was decomposed into 4f^(4)6p,4f^(3)5d^(2) and 4f^(3)5d6p,and their fractions,for the first time.were determined to be 0.12-0.13,0.88-0.85 and 0-0.02,respectively. | LU Fuquan WU Songmao WANG Yau sen SHI Wei SHI Peixiong SONG Linggen YANG Jianjun TANG Jiayong YANG Fujia | 1990 | Chinese Physics Letters1990，7，1： | 0 |
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