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| 1 | Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi显示文摘BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent years.However,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well understood.In this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and caspase-8.METHODS:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 proteins.RESULTS:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and prolonged.However,it did not significantly influence the expression of Bcl-2.CONCLUSION:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8. | Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 17 |
| 2 | ON A MULTILINEAR OSCILLATORY SINGULAR INTEGRAL OPERATOR(I)显示文摘ONAMULTILINEAROSCILLATORYSINGULARINTEGRALOPERATOR(I)CHENWENGUHUGUOENLUSHANZHENManuscriptreceivedOctober18,1994.RevisedDece... | CHEN WENGU * HU GUOEN * LU SHANZHEN * Manuscript received October 18, 1994. Revised December 13, 1995. *Department of Mathematics, Beijing Normal University, Beijing 100875, China. **Project supported by the National Natural Scienc | 1997 | Chinese Annals of Mathematics,Series B1997，18，2： | 8 |
| 3 | A mechanism for enhanced photocatalytic activity of nano-size silver particle modified titanium dioxide thin films显示文摘Ag-TiO2 nanostructured thin films with silver volume fraction of 0–20% were deposited on silicon and quartz substrates by RF magnetron sputtering and annealed in ambient air at 950°C for 1 h. The phase structure and surface topography of the films were characterized by X-ray diffractometer and transmission electron microscope. Photocatalytic activity of the films was evaluated by light induced degradation of methyl orange (C14H14N3NaO3S) solution using a high pressure mercury lamp as lamp-house. The relation of photocatalytic activity and silver content was studied in detail. It was found that silver content influences phase structure of TiO2 thin films, and silver in the films is metallic Ag (Ag0). With increasing silver content from 0 to 20 vol%, photocatalytic activity of the films increases first and then decreases. A suitable amount (2.5–5 vol%) silver addition can significantly enhance the photocatalytic activity of TiO2 films. The enhanced photocatalytic activity was mainly attributed to the extension of visible light absorption region of the films, the presence of anatase phase, the increase of oxy-gen anion radicals O2? and reactive center of surface Ti3+, and the better separation between electrons and holes on the films surface. | MENG FanMing1,2,3*, LU Fei1,3, SUN ZhaoQi1,3 & Lü JianGuo1,2,4 1 School of Physics and Materials Science, Anhui University, Hefei 230039, China 2 Key Laboratory of Materials Modification by Laser, Ion and Electron Beams (Dalian University of Technology), Ministry of Education, Dalian 116024, China 3 Anhui Key Laboratory of Information Materials and Devices, Anhui University, Hefei 230039, China 4 Department of Physics and Electronic Engineering, Hefei Normal University, Hefei 230061, China | 2010 | Science China(Technological Sciences)2010，53，11： | 4 |
| 4 | Clinical and laboratory characteristics associated with a high optical density anti-platelet factor 4 ELISA test显示文摘 | Lu BY Kudlowitz D Gardner LB | 2015 | J Blood Med2015，6，： | 1 |
| 5 | The clinical characteristics and prognosis of Chinese early stage breast cancer patients:a retrospec- tive study显示文摘 | Lu WL Li HX Qian BY | 2010 | Breast J2010，16，3： | 1 |
| 6 | Assay of disulfide oxidase and isomerase based on the model of hirudin folding 显示文摘 | Lu BY Chang JY | 2005 | Anal Biochem2005，339，1： | 1 |
| 7 | Predictive value of rapid shallow breathing index measured at initiation and termination of a 2-hour spontaneous breathing trial for weaning outcome in ICU patients显示文摘 | Kuo PH Wu HD Lu BY | | 0，，： | 1 |
| 8 | Assessing sequence plasticity of a virus-like nanoparticle by evolution toward a versatile scaffold for vaccines and drug delivery显示文摘 | Lu Y Chan W Ko BY | 2015 | Proc Natl Acad Sci USA2015，112，12： | 1 |
| 9 | The clinical characteristics and prognosis of Chinese early stage breast cancer patients: a retro- spective study显示文摘 | Lu WL Li HX Qian BY | 2010 | Breast J2010，16，3： | 1 |
| 10 | The clinical characteristics and prognosis of Chinese early stage breast cancer patients:a relrospective study显示文摘 | Lu WL Li HX Qian BY | 2010 | Breast J2010，16，3： | 1 |
| 11 | Effects of propafenone, quinidine, and their combination on ventricular fibrillation threshold in dogs 显示文摘 | Lu F Zhang XM Mei BY | 1992 | Zhongguo Yao Li Xue Bao1992，13，4： | 1 |
| 12 | The clinical charecteristincs and prognosis of Chinese early stage breast cancer patients:a retrospective study显示文摘 | Lu WL Li HX Qian BY | 2010 | Breast J2010，16，3： | 1 |
| 13 | Protective effect of bamboo shoot oil on experimental nonbacterial prostatitis in rats 显示文摘 | Lu BY Cai HF Huang WS | 2011 | Food Chem2011，124，3： | 1 |
| 14 | Combined chemotherapy and extemal beanl radiation for stage IE and liE natural killer T-cell lymphoma of nasal cavity显示文摘 | Wang BY Lu JJ Ma X | 2007 | Leuk Lymphoma2007，48，2： | 1 |
| 15 | Assay of disulfide oxidase and isomerase based on themodel of hirudin folding显示文摘 | Lu BY Chang JY | 2005 | Anal Biochem2005，339，1： | 1 |
| 16 | Reciprocal changes in p27Kip1 and p21Cip1 in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors 显示文摘 | Fan Z Shang BY Lu Y | 1997 | Clin Cancer Res1997，3，： | 1 |
| 17 | Application and research progression of lapa- roscopic liver resection 显示文摘 | Jiang WS LU BY | 2008 | Minimally Invasive Medicine2008，3，5： | 1 |
| 18 | Micrometas- expression in with early-stage cervical cancer 显示文摘 | Wang HY Sun JM Lu HF tases dctected by cytokeratin 19 sentinel lymph nodes of patients | 2006 | Int J Gynecol Canc- er2006，16，2： | 1 |
| 19 | Surgical treatment and prognostic analysis of 93 cases of hilar cholangiocarcinoma显示文摘 | Zhang BY Lu Y Dong Q | | 0，，03： | 1 |
| 20 | Down-regulation of zinc transporter 8 in the pancreas of db/db mice is rescued by exendin-4 administration显示文摘 | Liu BY Jiang Y Lu Z | | 0，，： | 1 |
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