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| 1 | Seminal biomarkers for the evaluation of male infertility显示文摘为努力与他们的搭挡一起怀孕的男人,诊断工具被限制并且经常由仅仅标准精液分析组成。这基线测试用作男富饶的一个粗略的评价,离开需要另外的诊断 biomarkers 的病人和临床医生。精液从因此,这评论在某些男不孕情形在当前、新奇的精液的 biomarkers 上集中包括自然富饶,区分精子缺乏病原学,并且预言的繁殖的腺帮助了的男性包含分子的最高的集中繁殖技术成功。当前可得到的测试包括 antisperm 抗体试金, DNA 破碎索引,在 situ 杂交的精子荧光,和另外的历史的精子功能的测试。当前的试金的差的诊断能力导致了继续的努力发现更预兆的 biomarkers。genomics, epigenetics, proteomics, transcriptomics,和为新奇男不孕 biomarkers 的发展的 metabolomics 抓住诺言的地里的新兴的研究。TEX101, ECM1,和 ACRV1 的精液的基于蛋白质的试金已经是可得到的或在为临床的使用的最后的开发中。当我们试图理解男不孕的 pathophysiologic 过程, DNA, RNA,蛋白质,或代谢物的另外的面板正在被探索。未来冒险将需要继续数据集成和确认让临床上有用的不孕 biomarkers 的开发帮助男不孕诊断,处理,并且建议。 | Jared M Bieniek Andrei P Drabovich Kirk C Lo | 2016 | Asian Journal of Andrology2016，18，3： | 15 |
| 2 | 冠状动脉内皮功能障碍患者循环MOTS-c水平下调显示文摘MOTS-c是一种新发现的线粒体衍生肽,其在调节代谢稳态中起作用。该研究旨在研究在没有显著冠状动脉结构性病变的患者中循环MOTS-c水平是否也与内皮功能障碍相关。方法:纳入无冠状动脉结构性病变的复发性心绞痛并接受冠状动脉造影和内皮功能检测的患者40例。 | Qin Q Delrio S Wan J Jay Widmer R Cohen P Lerman LO Lerman A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 14 |
| 3 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 4 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 5 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 6 | Composting salmon farm mortalities with passive areration显示文摘 | Liao P H Vizcarra A T Chen A Lo K V | 1996 | Compost Science and Utilization1996，2，4： | 2 |
| 7 | Application of highresolution thermal infrared remote sensing and GIS to assess the urban heat island effect 显示文摘 | Lo C P Quattrovhi D A and Luvall J C | 1997 | International Journal of Remote Sensing1997，18，2： | 2 |
| 8 | Characterization of silane-modified immobilized gold colloids as a substrate for surface-enhanced Raman spectroscopy显示文摘 | Olson L G Lo Y S Beebe T P | 2001 | Analytical Chemistry2001，73，： | 1 |
| 9 | Time domain buffeting analysis of suspension bridge subjected to turbulent wind with effective action angle显示文摘 | Ding Q Lee P K K Lo S H | 2000 | Journal of Sound and Vibration2000，233，2： | 1 |
| 10 | Effect on hepatitis B virus DNA levds in children infected with different genotypes显示文摘 | Sangfelt P Norder H Magnius LO Interferon - alpha 2b treament in hepatitis B carriers | 1997 | Acta Paediatr1997，86，2： | 1 |
| 11 | Development and applications of the reciprocating plate显示文摘 | Lo P C Baird M H I Rama Rao N V | 1992 | Column Chem Eng Commun1992，116，： | 1 |
| 12 | Ethyl caffeate suppresses NF-kappa B activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin显示文摘 | Chiang Y M Lo C P Chen Y P | 2005 | Br J Pharmacol2005，146，3： | 1 |
| 13 | Real-time garbage collection for flash-memory storage systems of realtime embedded systems 显示文摘 | Chang L P Kuo T W Lo S W | 2004 | ACM Transactions on Embedded Computing Systems2004，3，4： | 1 |
| 14 | Urban indicators of China from radiance-calibrated digital DMSP OLS nighttime images显示文摘 | LO C P | 2002 | Annals of the Asso ciation of American Geographers2002，92，： | 1 |
| 15 | Enzymecatalyzed production and chemical composition of diacylglycerols from corn oil deodorizer distillate 显示文摘 | LO S K BAHARIN B S TAN C P | 2004 | Food Biotechnol2004，18，： | 1 |
| 16 | The effects of dietary supplementation of vitamins C and E on the a-tocopherol content of muscles, liver and kidney, on the stability of lipids, and on certain meat quality parameters of the longissimus dorsi of rabbits 显示文摘 | Lo Fiego D P Santoro P Macchioni P | 2004 | Meat Science2004，67，： | 1 |
| 17 | Effects of trimetazidine administration before thrombolysis inpatients with anterior myocardial infarction:short-term and long-term results显示文摘 | Di Pasquale P Lo Verso O Bucca V | 2002 | Cardiovasc Drug Ther2002，13，： | 1 |
| 18 | Microwave-hydrothermal decomposition of perfluorooctanoic acid in water by iron-activated persulfate oxidation显示文摘 | Lee Y C Lo S L Chiueh P T | | Water Research0，44，3： | 1 |
| 19 | On edge-graceful labelings of graphs显示文摘 | Lo S P | 1985 | Congressus Numerantium1985，50，： | 1 |
| 20 | Comparison of the LMA Supreme? with the LMA Proseal? forairway management in pa?tients anaesthetized in prone position显示文摘 | Lo' pez AM Valero R Hurtado P | 2011 | BritishJournal of An?aesthesia2011，107，2： | 1 |
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