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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Measurement of leaf and canopy photosynthetic C02 exchange in the field显示文摘 | Farageand P K Garcia R L | 1996 | Journal of Experimental Botany1996，47，304： | 1 |
| 3 | Can improved photosynthesis increase crop yields? 显示文摘 | Long S P Zhu X G Naidu S L | 2006 | Plant Cell Environ2006，29，： | 1 |
| 4 | Nuclear Magnetic Resonance studies of water mobility in bread during storage 显示文摘 | Chen P L Long Z Ruan R | 1997 | LWT- Food Science and Technology1997，30，2： | 1 |
| 5 | Nuclear magneticresonance studies of water mobility in bread duringstorage显示文摘 | Chen P L Long Z Ruan R | 1997 | Lebensmittel-Wissenschafl und-Technologie1997，30，2： | 1 |
| 6 | Can improvement in photosynthesis increase crop y eldsV显示文摘 | Long S P Zhu X G Naidu S L Ort D R | 2006 | Plant Cell Environment2006，29，3： | 1 |
| 7 | The maize epicuticular wax layer provides UV protection显示文摘 | Long L M Patel H P Cory W C | 2002 | Functional Plant Biology2002，30，1： | 1 |
| 8 | One step synthesis of silica-coated nanoparticles at room temperature and their luminescence properties显示文摘 | Wang Y L Lu J P Huang X F Long J X Tong Z F | 2008 | Materials Letters2008，62，19： | 1 |
| 9 | Immunological differences in Eimeria maxima:effect of a mixed immmunizing inocculum on heterologous challenge显示文摘 | LONG P L MILLARD B J | 1979 | Parasitol1979，79，： | 1 |
| 10 | Passive techniques for ground temperature control显示文摘 | Heuer C E Long E L Zarling J P | 1985 | Thermal Considerations in Frozen Ground Engineering Monograph Series by ASCE Technical Council on Cold Regions Engineering New York1985，1985，： | 1 |
| 11 | Mandibular coronoid fractures : treatment options 显示文摘 | Shen L Li J Li P Long J Tian W Tang W | 2013 | Oral Maxilfofac Surg2013，42，6： | 1 |
| 12 | Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4 CD25 regulatory T- cells of type 1 diabetic subjects 显示文摘 | LONG S A CEROSALET'FI K BOLLYKY P L | 2010 | Diabetes2010，59，2： | 1 |
| 13 | Rural Resident's Attitudes Toward Recreation and Tourism Development显示文摘 | ALLEN L R H R HAFER P T LONG | 1993 | Ournal of Travel Research1993，21，4： | 1 |
| 14 | Eimeria: Further studies on the immunisation of young chickens kept in litter pens显示文摘 | Long P L Millard B J | 1979 | Avian Pathol1979，8，3： | 1 |
| 15 | Photosynthesis-is it limiting to biomass production显示文摘 | Beadle C L Long S P | 1985 | Biomass1985，8，： | 1 |
| 16 | Reaction path of protein farnesyltransferase at atomic resolution显示文摘 | LONG S B CASEY P J BEESE L S | 2002 | Nature2002，419，： | 1 |
| 17 | Influence of coarse ag- gregate on the permeation, durability and the microstructure character- istics of ordinary Portland cement concrete显示文摘 | BASHEER L BASHEER P A M LONG A E | 2005 | Construction and Build- ing Materials2005，，19： | 1 |
| 18 | Can improved photosynthesis increase crop yields? 显示文摘 | LONG S P ZHU X G NAIDU S L | 2006 | Plant Cell Environ2006，29，： | 1 |
| 19 | Eimeria of American chickens:character-stics of six attenuated strains produced by selection for precociousdevelopment显示文摘 | Long P L Johnson J K | 1988 | Avian Pathology1988，17，： | 1 |
| 20 | Can improvement in photosynthesis increase crop yields显示文摘 | Long S P Zhu X G Naidu S L | 2006 | Plant Cell Environ2006，29，： | 1 |
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