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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Cerivastatin, an inhibitor of 3 - hydroxy - 3 - methylglutaryl coenzyrne A reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models显示文摘 | Loic V Claudine S Farroch M | 2002 | Arteoselerosis thrombosis and vascular biology2002，22，： | 1 |
| 3 | Scattering of Laser Pulses (Plane Wave and Focused Gaussian Beam)by Spheres 显示文摘 | LOIC M GERARD G | 2001 | Appl Opt2001，40，15： | 1 |
| 4 | Enzyme-linked immunosorbent assay testing of shoots grown in vitro and the use of immnnocapture-reverse transcriptionpolymerase chain reaction improve the detection of Prunus necrotic ringspot virus in rose显示文摘 | Benoit M Loic C Jean-Paul O | 2000 | Phytopathology2000，90，5： | 1 |
| 5 | Intake of Flavonoida and Lung Cancer显示文摘 | Loic L M Suzanne P M Jean H H | 2000 | Journal of the National Cancer Institute2000，92，2： | 1 |
| 6 | AB?, crosstalk with ethylene and nitric oxide in seed dormancy and germination 显示文摘 | Erwann A Julien S Francoise C Loic R Annie M | 2013 | Frontiers in Plant Science2013，4，： | 1 |
| 7 | Cerivastatin,an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase,inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in invivo models显示文摘 | Loic V Claudine S Farroch M | 2002 | Arteosclerosis Thrombosis and Vascular Biology2002，22，： | 1 |
| 8 | Cerivastatin, an inhibitor of 3-methylglutaryl coenzyme,A reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in invivo models显示文摘 | Loic V Claudine S Farroch M | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 9 | 3D negative electrode stacks for integrated all-solid-state lithium microbatteries显示文摘 | Loic Baggetto Harm C M Knoops Rogier A H Niessen | 2010 | J Mater Chem2010，20，： | 1 |
| 10 | Controlling lipidaccumulation in cereal grains 显示文摘 | Guillaume B Loic L Peter M | 2012 | Plant Science2012，18，： | 1 |
| 11 | Electroche miluminescence -based fibre optic biosensors for flow injection analysis of glucoseand lactate in natural samples 显示文摘 | Christophe A M Loic J B | 1999 | Anal Chem Acta1999，381，： | 1 |
| 12 | Grain growth-controlled giant permittivity in soft chemistry CaCu3Ti4Olz ceramics显示文摘 | LOIC M SOPHIE G F BERNARD D | 2008 | Journal of the American Ceramic Society2008，91，2： | 1 |
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