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| 1 | Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis显示文摘AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic rats.METHODS Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney. | Gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis显示文摘Cirrhosis is associated with marked abnormalities in the circulatory function that involve a reduction in systemic vascular resistance. An important cause of this vasodilatation is the increased production or activity of nitric oxide(NO) in the splanchnic circulation. During portal hypertension and cirrhosis an increased endothelial NO synthase(e NOS) activity is demonstrated in splanchnic vessels. In contrast, the activity of e NOS in the cirrhotic liver is decreased, which suggests a different regulation of e NOS in the liver and in the splanchnic vessels. Asymmetric dimethylarginine(ADMA) is an endogenous NO inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk in both the general population and among patients with cirrhosis. It has been demonstrated that the liver is a key player in the metabolism of ADMA. This observation was further supported by investigations in human patients, showing a close correlation between ADMA plasma levels and the degree of hepatic dysfunction. ADMA is degraded to citrulline and dimethylamine by dimethylarginine dimethylaminohydrolases(DDAHs). DDAHs are expressed as type 1 and 2 isoforms and are widely distributed in various organs and tissues, including the liver. In this review, we discuss experimental and clinical data that document the effects of dimethylarginines on vascular function in cirrhosis. Our increasing understanding of the routes of synthesis and metabolism of methylarginines is beginning to provide insights into novel mechanisms of liver disease and allowing us to identify potential therapeutic opportunities. | Paloma Lluch Gloria Segarra Pascual Medina | 2015 | World Journal of Gastroenterology2015，21，32： | 2 |
| 3 | A survey of genes differentially expressed during long-term heat-induced chilling tolerance in citrus fruit显示文摘 | MaríaTeresa Sanchez-Ballesta Yolanda Lluch MaríaJosé Gosalbes | 2003 | Planta2003，218，1： | 1 |
| 4 | precutaneous fixaton of supracondylar fractures of the humems in children 显示文摘 | Arino VI Lluch EE Ramirez AM | 1977 | J Bone Joint Surg(Am)1977，59，： | 1 |
| 5 | Circulating HER2 extracellular domain and resistance to chemotherapy in advanced breast cancer 显示文摘 | Colomer R Montero S Lluch A | 2000 | Clin Cancer Res2000，6，6： | 1 |
| 6 | Signal Conditioning for GMR Magnetic Sensors Applied to Traffic Speed Monitoring GMR Sensors显示文摘 | Pelegri Sebastia Jose Alberola Lluch Jorge Lajara Vicaino J | 2007 | Sensors and Actuators2007，137，7： | 1 |
| 7 | The Extended Linear Expenditure System显示文摘 | Lluch C | 1973 | European Economic Review1973，，4： | 1 |
| 8 | Adsorption of Phosphorus on Sediments of the Balearic Islands (Spain) Related to Their Composition 显示文摘 | Lopez P X Lluch M Vidal J A Morgui | 1996 | Estuarine Coastal and Shelf Science1996，42，： | 1 |
| 9 | Molecular clo- ning and expression analysis of the mevalonate kinase gene from Arabidopsis thaliana 显示文摘 | Lluch M A Masferrer A Arr6 M | 2000 | Plant Mol Biol2000，42，2： | 1 |
| 10 | Effect of a high-protein breakfast on the postprandial ghrelin response显示文摘 | Blom WA Lluch A Stafleu A | 2006 | Am J Clin Nutr2006，83，2： | 1 |
| 11 | Effects of deep cervical flexor training on pressure pain thresholds over myofascial trigger points in patients with chronic neck pain显示文摘 | Lluch E Arguisuelas MD Coloma PS | 2013 | J Manipulative Physiol Ther2013，36，9： | 1 |
| 12 | An integrative genomic and proteomic analysis of PIK3CA,PTEN,and AKT mutations in breast cancer显示文摘 | STEMKE-HALE K GONZALEZ-ANGULO A M LLUCH A | 2008 | Cancer Res2008，68，15： | 1 |
| 13 | The Extended Linear Expenditure System 显示文摘 | Constantino Lluch | 1973 | European Economic Review1973，4，1： | 1 |
| 14 | Adsorption of Phosphorus on Sediments of the Balearic Islands (Spain) Related to Their Composition 显示文摘 | LOPEZ P LLUCH X VIDAL M | 1996 | Estuarine Coastal and Shelf Science1996，42，： | 1 |
| 15 | The Extended Linear Expenditure System显示文摘 | CONSTANTINO LLUCH | 1973 | European Economic Review1973，，4： | 1 |
| 16 | The use of quantum mechanics calculations for the study of corrosion inhibitors显示文摘 | Costa J M Lluch J M | 1984 | Corrosion Science1984，24，： | 1 |
| 17 | Consumer Demand Systems and Aggregate Consumption in the USA: An Application of the Extended Linear Expenditure System 显示文摘 | Constantino Lluch Ross Alan Williams | 1975 | Canadian Journal of Economics1975，8，1： | 1 |
| 18 | Adsorption of phosphoruson sediments of the balearic islands related to their composition 显示文摘 | Lopez P Lluch X MorgufJ A | 1996 | Esmarine Coastal and Shelf Science1996，42，： | 1 |
| 19 | A theoretical study of the ground and first excited singlet state proton transfer reaction in isolated 7-azaindole–water complexes显示文摘 | Ricard Casadesús Miquel Moreno José M. Lluch | 2003 | Chemical Physics2003，，2： | 1 |
| 20 | Immediate effects of active cranio-cervical flexion exercise versus passive mobilisation of the upper cervical spine on pain and performance on the cranio-cervical flexion test显示文摘 | Lluch E Schomacher J Gizzi L | 2014 | Man Ther2014，19，1： | 1 |
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