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| 1 | Lessons from “real life experience” of rifaximin use in the management of recurrent hepatic encephalopathy显示文摘BACKGROUND Hepatic encephalopathy(HE)is a major complication of cirrhosis with independent prognostic significance.The current management of HE is mainly based on lactulose.Rifaximin has been shown to decrease the risk of HE recurrence in patients with episodic forms.HE can also be persistent.However,there is no drug support recommendation for rifaximin use in this setting.AIM To assess the effectiveness of rifaximin in the management of recurrent episodes of HE and recurrent acute exacerbations on persistent HE,in“real life conditions”.METHODS In this retrospective study,using a within-subjects design,we collected data of patients treated with rifaximin for HE in two liver diseases centers,during the six-month period before and during the six-month period after the initiation of rifaximin.The primary effectiveness endpoint was the total number of HE events involving hospitalization.RESULTS Rifaximin was introduced for prevention of recurrent HE episodes in 29 out of 62 patients with normal mental status between episodes and for prevention of recurrent acute exacerbations on persistent HE in 33 out of 62 patients.In the“prevention of recurrent HE episodes”group,fewer HE events(0.79 vs 1.78;P=0.013)were reported during the period of time when rifaximin was used.In the“prevention of recurrent acute exacerbations on persistent HE”group,there was no significant difference in the number of HE-events(1.48 vs 1.77;P=0.582).CONCLUSION In this real-life experience,the effectiveness of rifaximin was confirmed in the prevention of HE episodes recurrence but was not proved in the prevention of acute exacerbations recurrence on persistent HE. | Fiona Chautant Maeva Guillaume Marie-Angèle Robic Jean-François Cadranel Jean-Marie Peron Hortensia Lison Charlène Cool Christophe Bureau Véronique Duhalde | 2020 | World Journal of Hepatology2020，12，1： | 3 |
| 2 | Efficacy of sustained blood levels ofinterleukin-1 recep0tor antagonist in anmimal model of arthritis显示文摘 | Lison Bendele Tracy Mcabee Gine Sennello | 1999 | ArthritisRheum1999，42，3： | 1 |
| 3 | The nanosilicahazard:another variable entity显示文摘 | Napierska D Thomassen L C J Lison D | 2010 | Particle and Fibre Toxicology2010，7，： | 1 |
| 4 | The nanosilica hazard:another variable entity显示文摘 | NapierskaD Thomassen LC Lison D | 2010 | Part Fibre Toxicol2010，7，： | 1 |
| 5 | Applications of liquid chromatog- raphy coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review显示文摘 | Roux A Lison D Junot C | 2011 | Clin Biochem2011，44，1： | 1 |
| 6 | Anterior and combined antero-posterior fusion for lumbar disc pain,A preliminary study显示文摘 | Lison MA Williams H | 1991 | Spine1991，16，： | 1 |
| 7 | Fast-track cardiac anesthesia: efficacy and safety of remifentanil versus sufentanil显示文摘 | Lison S Schill M Conzen P | 2007 | J Cardiothorac Vase Anesth2007，21，1： | 1 |
| 8 | Reactivity of carbon nanotubes:free radical generation or scavenging activity? 显示文摘 | Fenoglio I Tomatis M Lison D Muller J Fonseca A Nagy J B | 2006 | Free Radic Biol Med2006，40，： | 1 |
| 9 | Human toxicity of cobalt-containing dust and experimental studies on the mechanism of interstitial lung disease (hard metal disease)显示文摘 | Lison D | 1996 | Crit Rev Toxicol1996，26，6： | 1 |
| 10 | Percutaneous coronarv iutervention after subcutaeous enoxpariu pretreatment inpatients with unstable anginapectoris显示文摘 | Collet JP Montalescot G Lison L | 2001 | Circulation2001，103，： | 1 |
| 11 | Respiratory toxicity of carbon nanotubes:how worried should we be?显示文摘 | MULLER J HUAUX F LISON D | 2006 | Carbon2006，44，6： | 1 |
| 12 | Sintered indium-tin-oxide (ITO) particles:a new pneumotoxic entity显示文摘 | LISON D LALOY J CORAZZARI I | | 0，，02： | 1 |
| 13 | Comparative evaluation of in vitro micronucleus test and the alkaline single cell gel electrophoresis assay for the detection of DNA damaging agents:Genotoxie effects of cobalt prouder,tungsten carbide and cobalt-tungsten carbide显示文摘 | Goethem F V lison D Kitsch-Voiders M | 1997 | Mutation Research1997，392，： | 1 |
| 14 | Nanoscale atomic lithography with a cesium atomic beam显示文摘 | F. Lison H.-J. Adams D. Haubrich M. Kreis S. Nowak D. Meschede | 1997 | Applied Physics B Lasers and Optics1997，，3： | 1 |
| 15 | Direct determination of glycidyl esters of fatty acids in vegetable oils by LC - MS 显示文摘 | BLUMHORST M R VENKITASUBRAMANIAN P COL- LISON M W | 2011 | J Am Oil Chem Soc2011，88，9： | 1 |
| 16 | Percutaneous coronary intervention after subcutaneous enosaparin pretreatment patients with untable anginapectoris显示文摘 | Montalescot G Collet JP Lison L | 2001 | Circulation2001，103，： | 1 |
| 17 | Percutaneous coronary intervention after subcutaneous enoxaparin pretreatment in patients with unstable angina pectoris显示文摘 | Colet JP Montalescot G Lison L | 2001 | Circulation2001，103，5： | 1 |
| 18 | Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assays显示文摘 | Lison D Thomassen LC Rabolli V | 2008 | Toxicol Sci2008，104，1： | 1 |
| 19 | Sulfur mustard upregulates the expression of interleukin-8 in cultured human keratinocytes 显示文摘 | Lardot C Dubois V Lison D | 1999 | Toxicol Lett1999，110，12： | 1 |
| 20 | A polymorphism of the ability to smell urinary metabolites of asparagus显示文摘 | LISON M BLONDHEIM SH MELMED RN | 1980 | Br Med J1980，281，： | 1 |
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