|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Low level of p27kip1 protein expression in gastric adenocarcinoma is associated with disease progression and poor ont-come显示文摘 | Nitti D Belluco C Mammano E Marchet A Ambrosi A Mencarelle R Segato P Lise M | 2002 | J Surg Oncol2002，81，： | 1 |
| 3 | Meta-analysis of hepatic arterial infusion for unresectable liver metastases from colorectal Cancer:the end of an era? 显示文摘 | Moeellin S Pilati P Lise M | 2007 | J Clin Oncol2007，25，： | 1 |
| 4 | Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC) 显示文摘 | Franceschi S Lise M Tr6po C | 2011 | Cancer Epidemiol Biomarkers Prev2011，20，1： | 1 |
| 5 | Inhibition of Adenovirus Infection and Adenain by Green Tea Catechins 显示文摘 | JOSEPH M ANGELIQUE R LISE I | 2003 | Antiviral Research2003，，58： | 1 |
| 6 | Clinical correlations of alpha2,6-sialyltransferase expression in colorectal cancer patients显示文摘 | Lise M Belluco C Perera S P | 2000 | Hybridoma2000，19，： | 1 |
| 7 | Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non - smoking, Norwegian women in the HUNT 2 study 显示文摘 | Margrete M H Lise B A Berit B I | 2010 | Environl Res2010，110，5： | 1 |
| 8 | Voluntary contrac- tion of the tensor tympani muscle and its audiometric effects 显示文摘 | Angeli RD Lise M Tabajara CC | 2013 | Journal of Laryngology and Otology2013，127，： | 1 |
| 9 | Carvedilol or propranolol in portal hypertension? A randomized comparison显示文摘 | Lise Hobolth S?ren M?ller Henning Gr?nb?k Klaus Roelsgaard Flemming Bendtsen Erik Feldager Hansen | 2012 | Scandinavian Journal of Gastroenterology2012，，4： | 1 |
| 10 | Formalin-fixed paraffin embedded tissue: the holy grail of clinical proteomics显示文摘 | Valérie B Lise P Evelyne M | 2014 | Proteomics Clinical Application2014，8，10： | 1 |
| 11 | Incidence of thyroid cancer in Italy,1991-2005:time trends and age-period-cohort effects显示文摘 | Dal Maso L Lise M Zambon P | 2011 | Ann Oncol2011，22，4： | 1 |
| 12 | Incidence of thyroid cancer in It- aly,1991-2005: time trends and age-period-cohort effects显示文摘 | Maso L Lise M Zambon P | 2011 | Ann Onc2011，22，： | 1 |
| 13 | Genetic variation within and among Danish brow trout hatchery strains,assessed by PCR-RFLP analysis of mitochondrial DNA segments 显示文摘 | Michael M H Karen lise D M Gorm R | 1997 | Aquaculture1997，153，12： | 1 |
| 14 | Stimulation of protein synthesis and expansion of pig blastocysts by insulin in vitro显示文摘 | LEWIS A M KAYE P L LISING R | 1992 | Reprod Fertil Dev1992，4，1： | 1 |
| 15 | Incidence ofthyroid cancer in Italy, 1991-2005: time trends and ageperiod-cohort effects 显示文摘 | DAL MASO L LISE M ZAMBON P | 2011 | Ann Oncol2011，22，4： | 1 |
| 16 | Prognostic factors affecting long term outcome after liver resection for hepatocellular carcinoma:results in a series of 100 Italian patients显示文摘 | Lise M Bacchetti S Da PP | | Cancer0，，： | 1 |
| 17 | Meta-analysis of hepatic arterial infusion for unresectable liver metastases from colorectal cancer the end of an era显示文摘 | Mocellin S Pilati P Lise M | 2007 | J Clin Oncol2007，25，35： | 1 |
| 18 | Both growth hormone and exgenous glutamine increase gastrointestinal glutamine uptake in trauma显示文摘 | Marianne M Lise B | 1997 | Ann Surg1997，225，1： | 1 |
| 19 | Radiation exposure during fluo- roscopy : should we be protecting our thyroids? 显示文摘 | TSE V LISING J KHADRA M | 1999 | Aust N Z J Surg1999，69，12： | 1 |
| 20 | lncidence of thyroid cancer in Italy, 1991-2005 : time trends and age-period-cohort effects显示文摘 | Maso L Lise M Zambon P | 2011 | Ann Onc2011，22，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员