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| 1 | 抗氧化剂一、二级预防随机试验中的死亡率系统回顾及汇总分析显示文摘背景:抗氧化剂正用于多种疾病的预防。
目的:评估补充抗氧化剂对一、二级预防随机临床试验参试者死亡率的影响。数据来源及试验选择:检索2005年10月前的电子数据库以及发表的文献目录。所有于成人中进行的、比较单独或联合使用β胡萝卜素、维生素A、维生素C(抗坏血酸)、维生素E及硒剂的安慰剂或空白治疗对照随机试验均纳入分析。使用随机、盲法及随访作为评估入选试验偏倚的指标。采用随机效应分析法分析抗氧化剂对全因死亡率的影响,结果以相对危险度(relative risk,RR)及其95%可信区间(confidence interval,CI)表示。采用汇总回归评估试验协变量的影响。
数据提取:共入选68项随即试验,包括232606例参试者(385篇文章)。
数据整合:将所有低和高偏倚风险抗氧化剂试验汇总后发现,抗氧化剂对死亡率无显著影响(RR,1.02;95%CI,0.98~1.06)。多变量汇总回归分析表明,低偏倚风险试验(RR,1.16;95%CI,1.05~1.29)和硒剂(RR,0.998;95%CI,0.997~0.9995)与死亡率显著相关。在包括180938例参试者在内的47项低偏倚试验中,补充抗氧化剂显著增加死亡率(RR,1.05;95%CI,1.02~1.08)。排除硒剂试验后,在低偏倚风险试验中,β胡萝卜素(RR,1.07;95%CI,1.02~1,11)、维生素A(RR,1.16;95%CI,1.10~1.24)以及维生素E(RR,1.04;95%CI,1.01~1.07)单独或联合使用均显著增加死亡率。维生素C及硒剂对死亡率无显著影响。
结论:β胡萝卜素、维生素A及维生素E治疗可能增加死亡率。维生素C和硒剂对死亡率的影响需要进一步研究。 | Goran Bjelakovic Dimitrinka Nikolova Lise Lotte Gluud Rose G. Simonetti Christian Gluud 顾佳(译) | 2007 | 美国医学会杂志(中文版)2007，26，5： | 35 |
| 2 | 属间体细胞杂交创建甘蓝型油菜细胞质雄性不育系及其鉴定显示文摘利用原生质体融合技,获得了甘蓝型油菜品种中双4号与新疆野生油菜野油18的对称性体细胞杂种。杂种当代建成的6株植株中有2株雄性不育株。用中双4号做轮回亲本与不育株回交,不育株率随回交代数增加而升高,至BC3代大部分株系的不育株率接近100%,到BC4代不育性稳定,群体中无育性分离现象。用波里马CMS的恢复系和保持系与其测交,6个甘蓝型油菜品系均可保持该不育系的不育性,表明该雄性不育胞质与Pol不育胞质不同。 | 胡琼 李云昌 梅德圣 方小平 Lise N. Hansen Sven B. Andersen | 2004 | 中国农业科学2004，37，3： | 40 |
| 3 | Diagnostic procedures for submucosal tumors in the gastrointestinal tract显示文摘This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscppy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools. | Laura Graves Ponsaing Katalin Kiss Annika Loft Lise Ingemann Jensen Mark Berner Hansen | 2007 | World Journal of Gastroenterology2007，13，24： | 25 |
| 4 | The Simultaneous Repression Of CCR and CAD, Two Enzymes of the Lignin Biosynthetic Pathway, Results in Sterility and Dwarfism in Arabidopsis thaliana显示文摘Cinnamoyl CoA reductase (CCR ) 和 cinnamyl 白酒脱氢酶(CAD ) 催化 monolignol 生合成的最后步骤。在 Arabidopsis,一 CCR 基因(CCR1, At1g15950 ) 并且二 CAD 基因(CAD C At3g19450 和 CAD D At4g34230 ) 涉及这条小径。三倍的恶棍 c 恶棍 d ccr1 变异的、命名 ccc,被获得。这异种显示严格的矮子显型和男绝育。在 ccc 的木质素内容成熟的茎被归结为 50% 野类型的水平。另外,茎木质素结构严重地被影响,在抵抗内部单位的契约和加入由戏剧的丰富出现进象 coniferaldehyde 那样的 monolignol 先锋的聚合物 sinapaldehyde,和 ferulic 酸。男绝育由于在花药内层的木质化的缺乏,它引起花药裂开并且花粉版本的失败。ccc hypolignified 茎积累黄酮醇 glycosides, sinapoyl malate 和 feruloyl malate 的更高的数量,它建议酉分的小径的重定向。因此, CAD 和 CCR 的缺席, monolignol 小径的关键酶,比他们中的每的单个缺席在显型上有更严重的后果。另一 CCR 感应(CCR2, At1g80820 ) 并且另一 CAD (CAD1, At4g39330 ) 不补偿主要 CCR 和 CAD 活动的缺席。CCR 和 CAD 活动的这缺乏不仅影响木质化,而且严重地影响植物的发展。当试着减少植物的木质素内容以便便于 lignocellulose-to-bioethanol 变换过程时,这些后果必须小心地被考虑。 | Johanne Thevenin Brigitte Pollet Bruno Letarnec Luc Saulnier Lionel Gissot Alessandra Maia-Grondard Catherine Lapierre Lise Jouanin | 2011 | Molecular Plant2011，4，1： | 18 |
| 5 | 抗体偶联药物质量控制和临床前评价专家共识显示文摘抗体偶联药物,即ADC(Antibody-Drug conjugate),是通过连接子(linker)将具有生物活性的小分子药物偶联至单克隆抗体(单抗)上而产生的。目前,绝大部分ADC是由靶向肿瘤抗原的抗体通过连接子与高效细胞毒性的小分子化学药物偶联而成。 | 王兰 郭莎 于传飞 王文波 付志浩 霍艳 王欣 耿兴超 刘丽 文海若 陈琰 Christopher Yu 蔺亚萌 方言 房健民 姚雪静 李新芳5 胡朝红 杨敬 Lise Loberg | 2018 | 中国药事2018，32，7： | 9 |
| 6 | 男性肥胖对精液质量和辅助生殖结局的影响显示文摘已有文献报道男性超重及肥胖造成内分泌紊乱,可能会降低男性的生育能力。然而,男性体重指数(BMI)对精液质量和辅助生殖结局的影响却仍具争议。本研究将肥胖男性与正常体重男性对比,探明男性BMI的升高对精液质量和辅助生殖结局的影响。本研究纳入的612例肥胖不育男性来自丹麦生育中心,记录身高和体重数据并计算BMI值。根据BMI值(kgm^-2)将男性分为4组:〈20为体重不足组,20-24.9为正常体重组,25—29.9为超重组,〉30为超重组。依据WHO指南进行常规精液分析,按照SCSA检测精液DNA完整性。结果发现,男性BMI对常规精液参数(包括精子浓度、精子数目、精子体积及活动力)并无统计学影响。此外,诸如受孕率、GQE等辅助生殖结局,妊娠结局并未因BMI的升高而受显著影响。 | Lise Thomsen Peter Humaidan Leif Bungum Mona Bungum | 2014 | Asian Journal of Andrology2014，16，5： | 9 |
| 7 | Principles and potential of the anaerobic digestion of waste-activated sludge显示文摘 | Lise Appels Jan Baeyens Jan Degrève Raf Dewil | 2008 | Progress in Energy and Combustion Science2008，，6： | 4 |
| 8 | Development and predictive validity of the cirrhosis-associated ascites symptom scale: A cohort study of 103 patients显示文摘AIM To develop a scale of domains associated with the health-related quality-of-life(HRQOL) in patients with cirrhosis-related ascites.METHODS We initially undertook literature searches and a qualitative study in order to design a cirrhosis-associated ascites symptom(CAS) scale describing symptoms with a potential detrimental impact on health related quality of life(HRQL)(the higher the score, the worse the symptoms). Discriminatory validity was assessed in a validation cohort including cirrhotic patients with(1) tense/severe;(2) moderate/mild; or(3) no ascites(controls). Patients also completed chronic liver disease questionnaire(CLDQ) and the Euro QoL 5-Dimensions 5-Level(EQ-5D-5L) questionnaire evaluating HRQL. The relation between scale scores was analysed using Spearman correlations. RESULTS The final CAS scale included 14 items. The equivalent reliability was high(Chronbach's alpha 0.88). The validation cohort included 103 patients(72% men, mean age 62.4 years). The mean scores for each question in the CAS scale were higher for patients with severe/tense ascites than for mild/moderate ascites and controls. Compared with controls(mean = 9.9 points), the total CAS scale score was higher for severe/tense ascites(mean = 23.8 points) as well as moderate/mild ascites(mean = 18.6 points)(P < 0.001 both groups). We found a strong correlation between the total CAS and CLDQ score(rho = 0.82, P < 0.001) and a moderate correlation between the CAS and the EQ-5D-5L score(0.67, P < 0.001). CONCLUSION The CAS is a valid tool, which reflects HRQOL in patients with ascites. | Agnete Nordheim Riedel Nina Kimer Anne-Sofie Houlberg Jensen Emilie Kristine Dahl Mads Israelsen Luise Aamann Lise Lotte Gluud | 2018 | World Journal of Gastroenterology2018，24，15： | 3 |
| 9 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 10 | 黑色电影是不是美国文化的一面镜子?显示文摘美国通过第二次世界大战而崛起,与参战初期不可同日而语。美国社会的各个层面都发生了巨变,连意识形态都有别于从前的时代。这些巨变对文化产生了影响,在那个混乱的年代,神奇的胶片世界中出现了人们闻所未闻的新鲜事物。40年代催生了美国“黑色电影”(Film Noir),一种在战后20年间长盛不衰的电影风格。本文将着眼于这一时期的美国文化,力求寻找到黑色电影和美国当代文化之间的关联性。为了研究这一关联性,我认为有必要从历史的大背景来看电影这种艺术形式,对人文历史进行一次追根溯源。 | Lise Hordnes 钟晓京 | 2011 | 东方艺术2011，，1： | 2 |
| 11 | Implications of CO2 emissions trading for short-run electricity market outcomes in northwest Europe显示文摘 | Yihsu Chen Jos Sijm Benjamin F. Hobbs Wietze Lise | | Journal of Regulatory Economics0，，： | 2 |
| 12 | High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer显示文摘 | Mads H. Rasmussen Niels F. Jensen Line S. Tarpgaard Camilla Qvortrup Maria U. R?mer Jan Stenvang Tine P. Hansen Lise L. Christensen Jan Lindebjerg Flemming Hansen Benny V. Jensen Torben F. Hansen Per Pfeiffer Nils Brünner Torben F. ?rntoft Claus L. Anders | 2013 | Molecular Oncology2013，，3： | 2 |
| 13 | 生物抑制剂解淀粉芽孢杆菌结合1-甲基环丙烯处理在果实采后病害控制及品质保持中的作用效果显示文摘以未经任何处理为对照,研究分别用商业氯水、1-甲基环丙烯(1-MCP)、解淀粉芽孢杆菌(PPCB004)处理和经1-MCP(100μL)预处理后,应用生物抑制剂PPCB004处理对番木瓜品种‘Solo’贮藏期间炭疽病(anthracnose)和拟茎点霉软腐病(phomopsis)的控制效果。 | Mohamed Salia Osman Dharini Sivakumar Lise Korsten | 2011 | 保鲜与加工2011，11，2： | 2 |
| 14 | RosBREED:bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops显示文摘The Rosaceae crop family(including almond,apple,apricot,blackberry,peach,pear,plum,raspberry,rose,strawberry,sweet cherry,and sour cherry)provides vital contributions to human well-being and is economically significant across the U.S.In 2003,industry stakeholder initiatives prioritized the utilization of genomics,genetics,and breeding to develop new cultivars exhibiting both disease resistance and superior horticultural quality.However,rosaceous crop breeders lacked certain knowledge and tools to fully implement DNA-informed breeding—a“chasm”existed between existing genomics and genetic information and the application of this knowledge in breeding.The RosBREED project(“Ros”signifying a Rosaceae genomics,genetics,and breeding community initiative,and“BREED”,indicating the core focus on breeding programs),addressed this challenge through a comprehensive and coordinated 10-year effort funded by the USDA-NIFA Specialty Crop Research Initiative.RosBREED was designed to enable the routine application of modern genomics and genetics technologies in U.S.rosaceous crop breeding programs,thereby enhancing their efficiency and effectiveness in delivering cultivars with producer-required disease resistances and market-essential horticultural quality.This review presents a synopsis of the approach,deliverables,and impacts of RosBREED,highlighting synergistic global collaborations and future needs.Enabling technologies and tools developed are described,including genome-wide scanning platforms and DNA diagnostic tests.Examples of DNA-informed breeding use by project participants are presented for all breeding stages,including pre-breeding for disease resistance,parental and seedling selection,and elite selection advancement.The chasm is now bridged,accelerating rosaceous crop genetic improvement. | Amy F.Iezzoni Jim McFerson James Luby Ksenija Gasic Vance Whitaker Nahla Bassil Chengyan Yue Karina Gallardo Vicki McCracken Michael Coe Craig Hardner Jason D.Zurn Stan Hokanson Eric van de Weg Sook Jung Dorrie Main Cassia da Silva Linge Stijn Vanderzande Thomas M.Davis Lise L.Mahoney Chad Finn Cameron Peace | 2020 | Horticulture Research2020，7，1： | 2 |
| 15 | Sap flow for beech(Fagus sylvatica L.)in a natural and a managed forest—effect of spatial heterogeneity显示文摘Aims Beech(Fagus sylvatica L.)is an important species in natural and managed forests in Europe.This drought-sensitive species dominates even-aged stands as well more natural stands composed of a mixture of tree species,age and size classes.This study evaluates the extent that heterogeneity in spacing and tree diameter affect the seasonal availability and use of water.Methods Two stands were evaluated:(i)a heterogeneous forest remnant(NAT)with trees up to;300 years old,a mean top height of 28.4 m and a total of 733 stems ha1with stem diameters averaging 18 cm and(ii)an even-aged 80-year old stand(MAN),with a height of 25 m,and a total of 283 stems ha1 with diameters averaging 38 cm.Stem sap flow,Js(g m2 s1),was continuously measured in 12(MAN)and 13(NAT)trees using 20-mm long heat dissipation sensors.Individual tree measures of sap flow were correlated using non-linear statistical methods with air vapour pressure deficit(D,hPa)and global radiation(Rg,J m2 day1),along with constraints imposed by reductions in soil water content(SWC).SWC was measured as volumetric%using time domain reflectometry.Important Findings The daily integrated Js(Js-sum)for trees growing in the evenly spaced MAN stand and trees in canopy and closed forest positions in NAT stand decreased as the availability of soil moisture was reduced.In the heterogeneous NAT stand,SWC in a recently formed canopy gap remained high throughout the vegetation period.Based on regression models,the predicted relative decrease in Js-sum for dry relative to moist soil water conditions in the closed forest(at mean daily D=10 hPa)was 7–11%for trees near the gap and 39–42%for trees in the closed forest.In MAN,the reduction in Js-sum was 29%in dry relative to moist conditions.Js-sum in the outer 20 mm of the xylem in NAT was lower than that in MAN and the rate of decline in Js with xylem depth was less in NAT than in MAN.In MAN,Js-sum in deep and outer xylem was negatively affected at low soil moisture availability;in NAT,this was the case for only the outer xylem indicating that deep roots could be important in supplying water at times of low soil moisture in the upper soil. | Lise Dalsgaard Teis Nørgaard Mikkelsen Annemarie Bastrup-Birk | 2011 | Journal of Plant Ecology2011，4，1： | 2 |
| 16 | Functional Analysis of Yeast bcs1 Mutants Highlights the Role of Bcs1p-Specific Amino Acids in the AAA Domain显示文摘 | Cécile Nouet Gilles Truan Lise Mathieu Geneviève Dujardin | 2009 | Journal of Molecular Biology2009，，2： | 2 |
| 17 | 《系统功能语言学--选择研究》评介显示文摘从学科发展的趋势来看,当代系统功能语言学日益呈现出跨学科、多视角的综合研究态势,各相关学科的交叉研究或界面研究也不断涌现。由三位国际知名学者LiseFontaine、TomBartlett和GerardO’Grady共同编著、剑桥大学出版社于2013年出版的《系统功能语言学——选择研究》(SystemicFunctionalLinguistics:Exploring Choice)一书是上述趋势的生动体现。 | 陆礼春 Lise Fontaine Tom Bartlett Gerard O'Grady | 2015 | 现代外语2015，38，4： | 2 |
| 18 | Denaturing High-performance Liquid Chromatography mutation analysis in patients with reduced Protein S levels 显示文摘 | Lise Bathum Anna-Marie Mtl nster Mads Nybo | 2008 | Clinica Chimica Acta 20082008，7681，： | 1 |
| 19 | Pd(O)-catalyzed allylie alkylation in the synthesis of (±)carbovir 显示文摘 | LISE LOTTE G TORE B | 1992 | Tetrahedron Letters1992，33，8： | 1 |
| 20 | Factors related to persistent fatigue following completion of breast cancer treatment显示文摘 | Celine Gelinas Lise Fillion | 2004 | Oncology Nursing Forum2004，31，2： | 1 |
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