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| 1 | Chemical composition of PM_(2.5) during winter in Tianjin,China显示文摘PM2.5 samples for 24 h were collected during winter in Tianjin,China. The ambient mass concentration and chemical composition of the PM2.5 were determined. Ionic species were analyzed by ion chromatog-raphy,while carbonaceous species were determined with the IMPROVE thermal optical reectance(TOR) method,and inorganic elements were measured by inductively coupled plasma-atomic emission spec-trometer. The daily PM2.5 mass concentrations ranged from 48.2 to 319.2 g/m3 with an arithmetic average of 144.6 g/m3. The elevated PM2.5 in winter was mostly attributed to combustion sources such as vehicle exhaust,heating,cooking and industrial emissions,low wind speeds and high relative humidity(RH) ,which were favorable for pollutant accumulation and formation of secondary pollutants. By chem-ical mass balance,it was estimated that about 89.1% of the PM2.5 mass concentrations were explained by carbonaceous species,secondary particles,crustal matters,sea salt and trace elements. Organic material was the largest contributor,accounting for about 32.7% of the total PM2.5 mass concentrations. SO42-,NO3-,Cl- and NH4+ were four major ions,accounting for 16.6%,11.5%,4.7% and 6.0%,respectively,of the total mass of PM2.5. | Jinxia Gu Zhipeng Bai Weifang Li Liping Wu Aixia Liu Haiyan Dong Yiyang Xie | 2011 | Particuology2011，9，3： | 60 |
| 2 | The Chinese Stroke Association scientific statement:intravenous thrombolysis in acute ischaemic stroke显示文摘The most effective medical treatment for acute ischaemic stroke(AIS)is to offer intravenous thrombolysis during the ultra-early period of time after the onset.Even based on the Consensus of Chinese Experts on Intravenous Thrombolysis for AIS in 2012 and 2014 Chinese Guidelines on the Diagnosis and Treatment of AIS,the rate of thrombolysis for AIS in China remained around 2.4%,and the rate of intravenous tissue plasminogen activator usage was only about 1.6%in real world.The indication of thrombolysis for AIS has been expanded,and contraindications have been reduced with recently published studies.In order to facilitate the standardisation of treating AIS,improve the rate of thrombolysis and benefit patients who had a stroke,Chinese Stroke Association has organised and developed this scientific statement. | Qiang Dong Yi Dong Liping Liu Anding Xu Yusheng Zhang Huaguang Zheng Yongjun Wang 无 | 2017 | Stroke & Vascular Neurology2017，2，3： | 56 |
| 3 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 4 | Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow. | Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 无 | 2018 | Stroke & Vascular Neurology2018，3，3： | 37 |
| 5 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 6 | Statistics-based Optimization of the Polarimetric Radar Hydrometeor Classification Algorithm and Its Application for a Squall Line in South China显示文摘A modified hydrometeor classification algorithm(HCA) is developed in this study for Chinese polarimetric radars. This algorithm is based on the U.S. operational HCA. Meanwhile, the methodology of statistics-based optimization is proposed including calibration checking, datasets selection, membership functions modification, computation thresholds modification,and effect verification. Zhuhai radar, the first operational polarimetric radar in South China, applies these procedures. The systematic bias of calibration is corrected, the reliability of radar measurements deteriorates when the signal-to-noise ratio is low, and correlation coefficient within the melting layer is usually lower than that of the U.S. WSR-88D radar. Through modification based on statistical analysis of polarimetric variables, the localized HCA especially for Zhuhai is obtained,and it performs well over a one-month test through comparison with sounding and surface observations. The algorithm is then utilized for analysis of a squall line process on 11 May 2014 and is found to provide reasonable details with respect to horizontal and vertical structures, and the HCA results—especially in the mixed rain–hail region—can reflect the life cycle of the squall line. In addition, the kinematic and microphysical processes of cloud evolution and the differences between radardetected hail and surface observations are also analyzed. The results of this study provide evidence for the improvement of this HCA developed specifically for China. | Chong WU Liping LIU Ming WEI Baozhu XI Minghui YU | 2018 | Advances in Atmospheric Sciences2018，35，3： | 32 |
| 7 | Theory of multivariate compound extreme value distribution and its application to extreme sea state prediction显示文摘In this paper, a new type of distribution, multivariate compound extreme value distribution (MCEVD), is introduced by compounding a discrete distribution with a multivariate continuous distribution of extreme sea events. In its engineering application the number over certain threshold level per year is fitting to Poisson distribution and the corresponding extreme sea events are fitting to Nested Logistic distribution, then the Poisson-Nested logistic trivariate compound extreme value distribution (PNLTCED) is proposed to predict extreme wave heights, periods and wind speeds in Yellow Sea. The new model gives more stable and reasonable predicted results. | LIU Defu WANG Liping PANG Liang | 2006 | Chinese Science Bulletin2006，51，23： | 23 |
| 8 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 9 | Statistical Characteristics of Raindrop Size Distribution in the Tibetan Plateau and Southern China显示文摘The characteristics of raindrop size distribution(DSD) over the Tibetan Plateau and southern China are studied in this paper, using the DSD data from April to August 2014 collected by HSC-PS32 disdrometers in Nagqu and Yangjiang, comprising a total of 9430 and 6366 1-min raindrop spectra, respectively. The raindrop spectra, characteristics of parameter variations with rainfall rate, and the relationships between reflectivity factor(Z) and rainfall rate(R) are analyzed, as well as their DSD changes with precipitation type and rainfall rate. The results show that the average raindrop spectra appear to be one-peak curves, the number concentration for larger drops increase significantly with rainfall rate, and its value over southern China is much higher, especially in convective rain. Standardized Gamma distributions better describe DSD for larger drops, especially for convective rain in southern China. All three Gamma parameters for stratiform precipitation over the Tibetan Plateau are much higher, while its shape parameter(μ) and mass-weighted mean diameter(D_m), for convective precipitation, are less. In terms of parameter variation with rainfall rate, the normalized intercept parameter(N_w) over the Tibetan Plateau for stratiform rain increases with rainfall rate, which is opposite to the situation in convective rain. The μover the Tibetan Plateau for stratiform and convective precipitation types decreases with an increase in rainfall rate, which is opposite to the case for D m variation. In Z–R relationships, like 'Z = AR^b', the coefficient A over the Tibetan Plateau is smaller, while its b is higher, when the rain type transfers from stratiform to convective ones. Furthermore, with an increase in rainfall rate, parameters A and b over southern China increase gradually, while A over the Tibetan Plateau decreases substantially, which differs from the findings of previous studies. In terms of geographic location and climate over the Tibetan Plateau and southern China, the precipitation in the pre-flood seasons is dominated by strong convective rain, while weak convective rain occurs frequently in northern Tibet with lower humidity and higher altitude. | Yahao WU Liping LIU | 2017 | Advances in Atmospheric Sciences2017，34，6： | 20 |
| 10 | Clinical diagnostic performance of the simultaneous amplification and testing methods for detection of the Mycobacterium tuberculosis complex for smear-negative or sputum-scarce pulmonary tuberculosis in China显示文摘 | Fan Lin Zhang Qing Cheng Liping Liu Zhibing Ji Xiaobing Cui Zhenling Ju Jingliang Xiao Heping | 2014 | Chinese Medical Journal2014，，10： | 19 |
| 11 | Poisson-Gumbel Mixed Compound Distribution and its application显示文摘With the development of offshore engineering, the joint probability study for extreme sea environments has been a subject of increasing interest for both mathematicians and engineers. However, the conventional multivariate probability distribution models do not describe the distribution of the occurrences of extreme sea states induced by typhoon, hurricane or winter storm, and thus fail to reflect the probability characteristics of sea environments in all the aspects. Extreme sea environments are typically to be found in storms like typhoon, and the occurrences of such storms in certain sea areas, varying from year to year, may be fitted to a discrete distribution. By compounding the discrete distribution with a bivariate continuous distribution of two extreme sea environments, a new kind of distribution-Bivariate Compound Extreme Value Distribution (BCEVD) is obtained in this note. This study proposes Poisson-Gum-bel Mixed Compound Distribution, one of the particular forms of BCEVD, and gives an | Defu Liu Shuqin Wen Liping Wang | 2002 | Chinese Science Bulletin2002，47，22： | 18 |
| 12 | Marine Geohazards: Review and Future Perspective显示文摘With offshore resource exploration moving to the deep water, marine geohazards have been attracting attention from the academic and industry. Research achievements of marine geohazards were reviewed in this paper. We analyzed and discussed typical issues among marine geohazards, including coastal erosion, submarine slope failure, turbidity current and special hazards induced by gas hydrate dissociation, in terms of their definition, distribution, characteristics and case studies. Major international projects on marine geohazards headed by the United States, Europe, Japan and other international organizations are introduced as well. Three marine geohazard survey methods, including geophysical survey, geotechnical exploration and in-situ observation, were summarized with a brief description of each approach, respectively. Especially, the history of marine geohazard researches in China is briefly reviewed, showing the disparity between China and developed countries in the study of marine geohazards narrows gradually. The potential research tendency in future was suggested. | JIA Yonggang ZHU Chaoqi LIU Liping WANG Dong | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 18 |
| 13 | Enhanced biological nutrient removal by the alliance of a heterotrophic nitrifying strain with a nitrogen removing ecosystem显示文摘从合成废水的氮移动在一个空运生物反应器(白长袍的) 被调查,在器官的碳下面与新奇不是自养的硝化细菌 Pseudonocardia ammonioxydans H9T 扩充了到从 0 ~ 12 的氮比率(Corg/N ) 。接种紧张的效果也在安定性质和化学的氧需求(货到付款) 的移动上被决定。二个实验室规模反应堆被设置完成在水力的保留的一样的物理化学的条件下面使状态硝化的一个马厩时间(HRT ) ,温度, pH 和溶解的氧() ,并且在定序的批模式下面操作了。水平在 0.5 1.5 mg/L 被保留由周期激动人心并且通风。每特定的 Corg/N 比率为 3 个星期的持续时间被继续。反应堆(BR2 ) 之一与 P 被接种。ammonioxydans H9T 周期性地在每 Corg/N 比率的开始。污泥容量的索引(SVI ) 与增加的 Corg/N 比率改善了,但是没有重要差别在二个反应堆之间被检测。BR2 与增加显示出氮移动的高水平不是自养的条件,和氨移动到达了到水平 82%88% ,在在在比 6 高的 Corg/N 比率的控制反应堆(BR1 ) 的比那高的 to10% 上面;然而,在试验性的反应堆的氨移动水平是多达 8% 比在在 Corg/N 的控制反应堆,比率比 2 降低降低。货到付款移动效率日益增多地反应堆在两个与增加的 Corg/N 比率增加了。货到付款移动百分比直到山峰价值 88%94% 在 BR2,多达 11% 比那高在在比 4 高的 Corg/N 比率的 BR1。氨和货到付款移动的山峰价值几乎与最高的数字与一致(18%27% 总计细菌的数字) 在 BR2 的外长的细菌,作为殖民地形成检测了单位(CFU ) 。而且,在 BR2 的氨和货到付款的移动是仔细与有为氨和货到付款的直到 0.82 和 0.85 的一个系数索引(R2 ) 的接种紧张的数字有关分别地。这些结果建议它在在高 Corg/N 比率与一个不是自养的硝化细菌接种的一个反应堆为氨和碳营养素移动是更有效的,推断不是自养的 nitrifers 将在有氨和货到付款的高水平的废水的处理实际上是更可得到的。 | Naeem ud din Ahmad XU Haiying CHEN Liping LIU Zhipei LIU Shuangjiang | 2008 | Journal of Environmental Sciences2008，20，2： | 17 |
| 14 | Applications of Wavelet Analysis in Differential Propagation Phase Shift Data De-noising显示文摘Using numerical simulation data of the forward differential propagation shift(ΦDP) of polarimetric radar, the principle and performing steps of noise reduction by wavelet analysis are introduced in detail. Profiting from the multiscale analysis, various types of noises can be identified according to their characteristics in different scales, and suppressed in different resolutions by a penalty threshold strategy through which a fixed threshold value is applied, a default threshold strategy through which the threshold value is determined by the noise intensity, or a ΦDPpenalty threshold strategy through which a special value is designed for ΦDPde-noising. Then, a hard- or soft-threshold function, depending on the de-noising purpose, is selected to reconstruct the signal. Combining the three noise suppression strategies and the two signal reconstruction functions, and without loss of generality, two schemes are presented to verify the de-noising effect by dbN wavelets:(1) the penalty threshold strategy with the soft threshold function scheme(PSS);(2) the ΦDPpenalty threshold strategy with the soft threshold function scheme(PPSS). Furthermore, the wavelet de-noising is compared with the mean, median, Kalman, and finite impulse response(FIR) methods with simulation data and two actual cases. The results suggest that both of the two schemes perform well, especially when ΦDPdata are simultaneously polluted by various scales and types of noises. A slight difference is that the PSS method can retain more detail, and the PPSS can smooth the signal more successfully. | HU Zhiqun LIU Liping | 2014 | Advances in Atmospheric Sciences2014，31，4： | 17 |
| 15 | Nano-formulations for transdermal drug delivery:A review显示文摘Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Use of traditional physical and chemical enhancers to improve the transdermal permeation rate by increasing drug solubility, diffusion coefficient, and reservoir effect is not feasible owing to the toxic side effects of the overuse of chemical penetration enhancers. Nanoformulations generally vary in size and range from 10 nm to 100 nm. The smaller particle size leads to increased drug permeability, stability, retention, and targeting, making nano-formulations suitable for transdermal drug delivery. The different applications of nano-formulations(vesicles or nanoparticles and nanoemulsions) have been widely studied. Here, the classification, characteristics, transdermal mechanism, and application of the most popular nano-formulations in transdermal drug delivery system are reviewed. | Xingli Zhou Ying Hao Liping Yuan Sushmita Pradhan Krista Shrestha Ojaswi Pradhan Hongjie Liu Wei Li | 2018 | Chinese Chemical Letters2018，29，12： | 17 |
| 16 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 17 | Spatial variations of macrozoobenthos and sediment nutrients in Lake Yangcheng: Emphasis on effect of pen culture of Chinese mitten crab显示文摘We determined the effect of Chinese mitten crab(CMC) pen culture on the quantified spatial distribution of the macrozoobenthic community and sediment nutrients in Lake Yangcheng.Redundancy analysis indicated that water temperature, macrophyte occurrence, sediment type, and crab culture were the main environmental factors that influence the spatiotemporal macrozoobenthic distribution. Macrozoobenthic assemblages in the lake were characterized by eutrophic indicator species. In the most polluted estuaries, the abundance and diversity indices of the whole community and abundance of chironomids and oligochaetes were significantly depressed, and sediment carbon(C) and phosphorus(P) were significantly enhanced compared with those in the western, middle(MB), and eastern basin(EB). Crab culture in this lake had significant effects on the species composition of the macrozoobenthic community in one of three CMC culture pens(CP), and generally depressed the abundance of most chironomid and oligochaete species. Significantly increased diversity, evenness, sediment carbon and nitrogen content, and sediment C:P ratio in the CP were found compared with those in the three basins.However, no conspicuous difference in sediment P content between the CP and the two basins of MB and EB was detected. Our results showed that the enhanced diversity and evenness of macrozoobenthos might be associated with the joint effect of macrophyte planting and crab predation, and macrophyte planting may modify the effects of CMC culture by leading to disproportional accumulation of C and N in the sediment relative to P in the CP of the lake. | Liping Chen Ying Zhang Qigen Liu Zhongjun Hu Yuejuan Sun Ziran Peng Lijing Chen | 2015 | Journal of Environmental Sciences2015，27，11： | 15 |
| 18 | Chemical and optical properties of aerosols and their interrelationship in winter in the megacity Shanghai of China显示文摘A field campaign on air quality was carried out in Shanghai in winter of 2012. The concentrations of NO, NO2, NOx, SO2, CO, and PM2.5increased during haze formation. The average masses of SO42-, NO3-and NH4+were 10.3, 11.7 and 6.7 μg/m3 during the haze episodes, which exceeded the average(9.2, 7.9, and 3.4 μg/m3) of these components in the non-haze days. The mean values for the aerosol scattering coefficient(b sp), aerosol absorption coefficient(b ap) and single scattering albedo(SSA) were 288.7, 27.7 and0.91 Mm-1, respectively. A bi-peak distribution was observed for the mass concentrations of CO, NO, NO2, and NOx. More sulfate was produced during daytime than that in the evening due to photochemical reactions. The mass concentration of NH4+achieved a small peak at noontime. NO3-showed lower concentrations in the afternoon and higher concentrations in the early morning. There were obvious bi-peak diurnal patterns for b sp and b ap as well as SSA. b sp and b ap showed a positive correlation with PM2.5mass concentration.(NH4)2SO4, NH4NO3, organic mass, elemental carbon and coarse mass accounted for 21.7%, 19.3%, 31.0%, 9.3% and 12.3% of the total extinction coefficient during non-haze days, and 25.6%, 24.3%, 30.1%, 8.1% and 8.2% during hazy days. Organic matter was the largest contributor to light extinction. The contribution proportions of ammonium sulfate and ammonium nitrate to light extinction were significantly higher during the hazy time than during the non-haze days. | Tingting Han Liping Qiao Min Zhou Yu Qu Jianfei Du Xingang Liu Shengrong Lou Changhong Chen Hongli Wang Fang Zhang Qing Yu Qiong Wu | 2015 | Journal of Environmental Sciences2015，27，1： | 14 |
| 19 | In vitro antibacterial activity of thymol and carvacrol and their effects on broiler chickens challenged with Clostridium perfringens显示文摘Background:In the post-antibiotic era,essential oils(EO) are promising alternatives to growth-promoting antibiotics.The aim of the present study was to investigate the antibacterial activities of an EO product and its components thymol and carvacrol in vitro,and the efficacy of EO to control Clostridium perfringens challenge in broiler chickens.Results:The in vitro minimum inhibitory concentration assay showed strong antibacterial activity of the EO product,thymol,and carvacrol against pathogenic Escherichia coli,C.perfringens,and Salmonella strains,and weak activity towards beneficial Lactobacillus strains.Besides,an additive effect was observed between thymol and carvacrol.The in vivo study was carried out with 448 male broiler chicks following a 4 × 2 factorial arrangement to test the effects of EO supplementation(0,60,120,or 240 mg/kg EO in wheat-based diet),pathogen challenge(with or without oral gavage of C perfringens from day 14 to day 20) and their interactions.Each treatment consisted of eight replicate pens(seven birds/pen).The challenge led to macroscopic gut lesions,and resulted in a significant increase in ileal populations of C.perfringens and Escherichia subgroup(P< 0.05) on day 21.Dietary EO supplementation did not influence C perfringens numbers,but linearly alleviated intestinal lesions on day 21 and 28(P=0.010 and 0.036,respectively),and decreased Escherichia populations in ileum with increased EO dosages(P=0.027 and 0.071 for day 21 and 28,respectively).For caecum,EO quadratically influenced Lactobacillus populations on day 21(p=0.002),and linearly decreased the numbers of total bacteria and Escherichia on day 28(P=0.026 and 0.060,respectively).Mean thymol and carvacrol concentrations in the small intestine were 0.21 and 0.20 μg/g in intestinal digesta(wet weight),respectively,for birds fed 60 mg/kg EO,and 0.80 and 0.71 μg/g,respectively,for birds fed 240 mg/kg EO.Conclusions:These results indicated that dietary EO supplementation could affect intestinal microbiota and alleviate intestinal lesions in broilers,which may contribute in controlling C.perfringens infection in broiler chickens. | Encun Du Liping Gan Zhui Li Weiwei Wang Dan Liu Yuming Guo | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 14 |
| 20 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
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