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| 1 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 2 | Performance of APACHE III over time in Australia and New Zealand- a retrospective cohort study 显示文摘 | Paul E Bailey M Van Lint A | 2012 | Anaesth Intensive Care2012，40，6： | 1 |
| 3 | Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo显示文摘 | Merezak C Reichert M Van Lint C | 2002 | J Virol2002，76，10： | 1 |
| 4 | Cryptoeoccal disease in patients with or without human immunodeficiency virus: clinical presentation and monitoring of serum cryptococcal antigen fiters显示文摘 | LINT Y YEH K M LIN J C | 2009 | J Micmbiolhnmunol Infect2009，42，3： | 1 |
| 5 | Application of the charge regulation model to transport of ions through hydrophilic membranes: one-dimensional transport model for narrow pores (nanofiltration) 显示文摘 | Lint D Biesheuvel W B Verweij P M | 2002 | Joumal of Colloid and Interface Science2002，251，1： | 1 |
| 6 | Stoichiometry of carbon, hydrogen, nitrogen, sulfur and oxygen in the particulate matter of the western North Pacific marginal seas显示文摘 | CHEN C LINT A HUANG C M | 1996 | Mar Chem1996，54，： | 1 |
| 7 | Factors predicting response and graft-versus-host disease after donor lymphocyte infusion:a study on 593 infusions显示文摘 | Raiola AM Van Lint MT Valbonesi M | 2003 | Bone Marrow Transplant2003，31，8： | 1 |
| 8 | A skew-normal mixture regression model显示文摘 | LIU M LINT I | 2014 | Educational and Psychological Mea- surement2014，74，： | 1 |
| 9 | Exaction of proteins from Pacific whiting mince at various washing conditions显示文摘 | LINT M PARK J M | 1996 | Food Science1996，61，2： | 1 |
| 10 | Extraction of proteins from pacific whiting mince at various washing conditions显示文摘 | LINT M PARK J W | 1996 | Journal of Food Science1996，61，2： | 1 |
| 11 | Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease显示文摘AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative recurrence.METHODS Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.910, P = 0.043) were also predictors of postoperative recurrence. No association was revealed between postoperative recurrence and smoking status, postoperative prophylactic treatment and the presence of myenteric plexitis and relapse.CONCLUSION The presence of severe submucosal plexitis with lymphocytes in the proximal resection margin is more likely to result in postoperative relapse in CD. | Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás Molnár | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 1 |
| 12 | Herpes simplex virus-specfic CD8 + T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation 显示文摘 | van Lint A Ayers M Brooks AG | 2004 | J Immunol2004，172，1： | 1 |
| 13 | Group Decision Making Using Incomplete Fuzzy Preference Relations Based on the Additive Consistency and the Order Consistency 显示文摘 | CI-IEN S M LINT E LEE L W | 2014 | In-formationSciences2014，259，3： | 1 |
| 14 | Recovered protein and reconditioned water from surimi processing waste显示文摘 | LINT M PARK J W MORRISSEY M T | 1995 | Journal of Food Science1995，60，1： | 1 |
| 15 | Herpes simDlex virus-specific CD8+T cells can clear established lyric infections from skin and nerves and can partially limit the early sDread of virus after cutaneous inoculation显示文摘 | VAN LINT A AYERS M BROOKS A G | 2004 | J Immunol2004，172，1： | 1 |
| 16 | Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration显示文摘 | MARMONT A M VAN LINT M T GUALANDI F | 1997 | Lupus1997，6，6： | 1 |
| 17 | Application of the charge regulation model to transport of ions through hydrophilic membranes: one-dimensional transport model for narrow pores (nanofiltration)显示文摘 | de Lint W B S Biesheuvel P M Verweij H | 2002 | Journal of Colloid and Interface Science2002，251，： | 1 |
| 18 | Short-term effects of hyposmotic shock on Na +/K +-ATPase expression in gills of the enryhaline milkfish, Chanos chanos 显示文摘 | LINT Y M CHEN C N YOSHINAGA T | 2006 | Comp Biochem Physiol A2006，143，3： | 1 |
| 19 | Antioxidative ability of lactic acid bacteria显示文摘 | LINT M Y YEN C L | 1999 | J Agric Food Chem1999，47，： | 1 |
| 20 | Nkx2-5:a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants显示文摘 | Lints T J Parsons L M Hartley L | 1993 | Development1993，119，3： | 1 |
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