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| 1 | Inhibitory effect of recombinant adenovirus carrying melittin gene on hepatocellular carcinoma显示文摘 | Ling CQ Li B Zhang C Zhu DZ Huang XQ Gu W Li SX | 2005 | 第二军医大学学报2005，26，10： | 30 |
| 2 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Influence of the symmetry energy on the balance energy of the directed flow显示文摘The influence of the density-dependent symmetry energy on the balance energy (E bal) of directed flow from heavy ion collisions (HICs) at incident energies covered by INDRA and MSU experiments is studied,using the updated version of the ultrarelativistic quantum molecular dynamics (UrQMD) model,especially adapted to low-energy heavy ion collisions (HICs).Four mass-symmetric reactions with total mass numbers between 192 and 394 are chosen for investigating the influence of the symmetry energy on the system-mass dependence of E bal.The results show that the uncertainty in the density dependence of the symmetry potential causes changes of E bal of the order of several MeV,depending on the type of particle considered.The E bal of neutrons from HICs is particularly sensitive to the density dependence of the symmetry potential energy,while the system-mass dependence of E bal of Z=1 particles is not. | GUO ChenChen WANG YongJia LI QingFeng TRAUTMANN W LIU Ling WU LiJuan | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 4 |
| 5 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 6 | Minireview dietary phytosterols:a review of metabolism,benefits and side effects显示文摘 | Ling W H Jones P J | 1995 | Life Science1995，57，： | 2 |
| 7 | Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein显示文摘 | Wang J Y Ling H Yang W | 2001 | EMBO J2001，20，24： | 1 |
| 8 | Minireview dietary phytosterols:a review metabolism,benefits and side effects 显示文摘 | Ling W H Jones P J H | 1995 | Life Science1995，51，3： | 1 |
| 9 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion显示文摘 | Ling W Chung J N Troutt T R | 1998 | J Fluid Mech1998，358，： | 1 |
| 10 | Effects of various metals and their loading methods on the mesopore formation in pitch-based spherical activated carbon 显示文摘 | Liu Z Ling L Qiao W | 1999 | Carbon1999，37，8： | 1 |
| 11 | Shooting and bouncing rays: calculating the RCS of an arbitrarily shaped cavity 显示文摘 | Ling H Chou Pt C Lee S W | 1989 | IEEE Transactions on Antennas and Propagation1989，37，2： | 1 |
| 12 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion 显示文摘 | Ling W Chung J N Troutt T R | 1998 | Journal of Fluid Mechanics1998，358，： | 1 |
| 13 | Development of a mode of application of bioorganic fertilizer for improving the biocontrol efficacy to Fusarium wilt 显示文摘 | Ling N Xue C Huang Q W | 2010 | Biocontro12010，55，： | 1 |
| 14 | Contrasting geochemical and Sm- Nd isotopic compositions of Archean metasediments from the Kongling high-grade terrain of the Yangtze craton: Evidence for cra- tonic evolution and redistribution of REE during crustal anatexis显示文摘 | Gao S Ling W L Qiu Y M | 1999 | Geochimica et Cosmochimica Acta1999，63，1314： | 1 |
| 15 | Spatial and temporal characterization of phase fluctuations in non-Kolmogorov atmospheric turbulenc显示文摘 | RAO C JIANG W LING N | 2000 | Journal of Modern Optics2000，47，： | 1 |
| 16 | 17-Beta Estradiol and Hydroxyestradiols Interact via the NFKappaB Pathway to Elevate Cyclooxygenase 2 Expression and Prostaglandin E2 Secretion in Human Bronchial Epithelial Cells显示文摘 | Ho C C Ling Y C Chang L W | | 0，，02： | 1 |
| 17 | Physical activity,diet and cardiovas- cular disease risks in Chinese women显示文摘 | Ma J Liu Z Ling W | 2003 | Public Health Nu- tr2003，6，2： | 1 |
| 18 | Multiscale distance matrix for fast plant leaf recognition显示文摘 | HU R JIA W LING H | 2012 | IEEE Transactions on Image Processing2012，21，11： | 1 |
| 19 | Assessment of impact factors on shear wave based liver stiffness measurement显示文摘 | Ling W Lu Q Quan J | 2013 | Eur J Radiol2013，82，： | 1 |
| 20 | The effects of washing and cooking on chlorpyrifos and its toxic metabolites in vegetables显示文摘 | Ling Y Wang H Yong W | 2011 | Food Control2011，22，1： | 1 |
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