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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet2001，，9286： | 4 |
| 3 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet . 2001 (9286)2001，，9286： | 4 |
| 4 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | 2001 (9286)2001，，9286： | 4 |
| 5 | Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance显示文摘 | Ling Yang Ping Li Suneng Fu Ediz S. Calay G?khan S. Hotamisligil | 2010 | Cell Metabolism2010，，6： | 2 |
| 6 | Preparation of mesocarbon microbeads from coal tar 显示文摘 | LU Y G LING L C WU D | 1999 | Journal of Material Science1999，34，16： | 1 |
| 7 | Diffusion with hydrolysis and ion association in aqueous solutions of beryllium sulfate 显示文摘 | Hao Ling Lu Ruanhui Derek G L | 1996 | Journal of Solution Chemistry1996，25，3： | 1 |
| 8 | Positive inductive effect of IL-2 on virus-specific cellular responses elicited by a PRRSV-ORF7 DNA vaccine swine 显示文摘 | Rompato G Ling E Chen Z | 2006 | Vet Immunol immunop2006，109，12： | 1 |
| 9 | Effects of expand- able graphite and ammonium polyphosphate on the flame-re- tardant and mechanical properties of rigid polyurethane fimms 显示文摘 | XIAN Y M LING Y XIAO G Z | 2009 | JApplPolymSci2009，114，： | 1 |
| 10 | An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast 显示文摘 | Bauman R A Ling G Tong L | 2009 | J Neurotraurna2009，26，6： | 1 |
| 11 | P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines显示文摘 | Bradley G Naik M Ling V | 1989 | Cancer Res1989，49，10： | 1 |
| 12 | Repeated administration of propofol upregulated the expression of c-Fos and cleaved-caspase-3 proteins in the developing mouse brain显示文摘 | CUI Y LING SHAN G YI L | 2011 | Indian J Pharmacol2011，43，1： | 1 |
| 13 | The symptom cluster of fatigue, pain,anxiety,and depression and the effect on the quality of life of women receiving treatment for breast eancer:a multieenter study显示文摘 | So WK Marsh G Ling WM | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 14 | Increased if-equency of regulator), T cells in peripheral blood and tu- rnout infiltrating lymphocytes in colorectal cancer patients 显示文摘 | LING K L PRATAP S E BATES G J | 2007 | Cancer Irnmun2007，28，7： | 1 |
| 15 | Intracellular localization of Herpes simplex virus type 1 thymidine kinase fused to diferent fluorescent proteins depends on choice of fluorescent tag显示文摘 | Ariane Sling Andreas Simm Nikolai G Rainov | 2002 | FEBS Letters2002，527，： | 1 |
| 16 | Co-Al2O3 Omposites Powder Prepared by Electroless Plating显示文摘 | Zhang C Ling G P He J H | 2004 | Materials Letters2004，58，： | 1 |
| 17 | Amorphous A1- Mn coating on NdFeB magnets: Electrodeposition from A1C13- EMIC- MnC1z ionic liquid and its corrosion behavior显示文摘 | Chen J Xu B J Ling G P | 2012 | Materi- als Chemistry and Physics2012，13，41： | 1 |
| 18 | Crowding clustering genetic algorithm for multimodal function optimization显示文摘 | Ling Q Wu G Yang Z Y | | 0，，01： | 1 |
| 19 | Determination of DNA by Use of the Molecular 'Light Switch' Complex of Ru(bipy)2(dppz)^2+ 显示文摘 | Ling L S He Z K Song G W | 2000 | Mikrochhn Acta2000，134，12： | 1 |
| 20 | Optimal and nonlinear control of systems with sandwiched bacldas-h显示文摘 | Tao G Ma X Ling Y | 2001 | Automatica2001，37，2： | 1 |
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