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| 1 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 2 | 中国慢性病的挑战与应对显示文摘中国在短短几十年内,完成了从传染病向慢性病的流行病学模式转变,转变速度远远高于其他许多国家。而行为模式的转变,包括膳食习惯变化、体力活动减少、高水平的男性吸烟率等危险因素是中国疾病模式快速转变的重要原因。其结果是,这些本可避免的慢性病的发病率和死亡率快速上升。引发了医疗卫生服务费用显著上升。目前,中国有1.77亿高血压患者,有3.03亿烟民(占世界烟民的1/3),并有5.3亿人遭受被动吸烟危害。 | Gonghuan Yang Lingzhi Kong Wenhua Zhao Xia Wan Yi Zhai Lincoln C Chen Jeffrey P Koplan | 2008 | 世界临床医学2008，2，6： | 5 |
| 3 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 4 | A novel plasminogen activator from Streptococcus uberis显示文摘 | Rosey E L Lincoln R A Ward P N | 1999 | FEMS Microbiol Lett1999，178，： | 1 |
| 5 | Membrane destabilizing properties of cell-penetrating peptides 显示文摘 | Thor6n PE Persson D Lincoln P | 2005 | Biophys Chem2005，114，23： | 1 |
| 6 | Validation of a new measure of protective footcare behaviour:the Nottingham Assessment of Functional Footcare(NAFF) 显示文摘 | Lincoln NB Jeffcoate WJ Ince P | 2007 | Practical Diabetes Int2007，24，4： | 1 |
| 7 | Engineering vitamin E content: from Arabidopsis mutant to soy oil显示文摘 | Van Eenennaam A L Lincoln K Durrett T P | 2003 | The Plant Cell2003，15，12： | 1 |
| 8 | MAPMAKER: an interactive computer package for constructing primary genetic maps of experimental and natural populations显示文摘 | Lander E S Green P Abrahamson J Barlow A Day M J Lincoln S E Newbury L | 1987 | Genetics1987，1，： | 1 |
| 9 | Natriuretic Peptides,Their Receptors and cGMP-dependent Signa-ling Functions显示文摘 | Lincoln R P Sarah A H Deborah M D | 2005 | Endocrine Reviews2005，16，： | 1 |
| 10 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul Christian Amaral Ansel P Oskouei Behzad Hu Ming-Chang Sloan Alexis Isakova Tamara Gutiérrez Orlando M Aguillon-Prada Robier Lincoln Joy Hare Joshua M Mundel Peter Morales Azorides Scialla Julia Fischer Michael Soliman Elsayed Z Chen J | 2011 | Journal of Clinical Investigation2011，，11： | 1 |
| 11 | Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation 显示文摘 | Lincoln AJ Wickramasinghe D Stein P | 2002 | Nat Genet2002，30，4： | 1 |
| 12 | DNA com- mission of the international society for forensic ge- netics: guidelines for mitochondrial DNA typing显示文摘 | Carracedo A Bar W Lincoln P eta! | 2000 | Forensic Sci Int2000，110，2： | 1 |
| 13 | Functional recovery of community stroke patients显示文摘 | Lincoln NB Gladman JRF Berman P | 2000 | Disabil Rehabil2000，22，3： | 1 |
| 14 | Purification and properties of a unique flavin-containing chloroperoxidase from the capitellid polychaete Notomastus lobatus显示文摘 | Lincoln D E Woodin S A | 1991 | J Bio Chem1991，266，23： | 1 |
| 15 | Binding of cell-penetrating penetratin peptides to plasma membrance vesicles correlates directly with cellular uptake显示文摘 | Amand HL Bostrom CL Lincoln P | 2011 | Bio- chim Biophys Acta2011，1808，12： | 1 |
| 16 | The effect of melatonin implants administered from December until April on plasma prolactin, triiodothyronine and thyroxine concentrations and on the timing of the spring moult in cashmere goats显示文摘 | Dicks P Russel A Lincoln G A | 1995 | Anita Sci1995，60，2： | 1 |
| 17 | Validation of a new measure of protective foot care behaviour: the Nottingham Assessment of Functional Foot care (NAFF) 显示文摘 | Lincoln NB Jeffcoate WJ Ince P | 2007 | Pract Diab Int2007，24，4： | 1 |
| 18 | Mechanism of DNA threa-ding intercalation of binuclear Ru complexes:Unior bi-molecular pathways depending on ligand structure and binding density显示文摘 | NORDELL P LINCOLN P | 2005 | J Am Chem Soc2005，127，： | 1 |
| 19 | Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation显示文摘 | Lukacs NW Strieter RM Warmington K Lincoln P Chensue SW Kunkel SL | 1997 | J Immunol1997，158，9： | 1 |
| 20 | MAPMAKER:an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations 显示文摘 | Lander E S Green P Abrahamson J Barlow A Daly M J Lincoln S E Newburg L | 1987 | Genomics1987，1174，181： | 1 |
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