|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | Metformin reverses fatty liver disease in obese,leptin-deficient mice显示文摘 | Lin HZ Yang SQ Chuckaree C | 2000 | Nat Med2000，6，： | 1 |
| 3 | Metormin reverses fatty liver disease in obese,leptin-deficient mice 显示文摘 | Lin HZ Yang SQ Chuckaree C | 2000 | Nat Med2000，6，9： | 1 |
| 4 | Metformin reverses fatty liver disease in obese, leptin-deficient mice显示文摘 | Lin HZ Yang SQ Chuckaree C | 2000 | Nat Med2000，6，9： | 1 |
| 5 | Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes显示文摘 | Lin HZ Yang SQ | 1999 | Gastroenterology1999，116，5： | 1 |
| 6 | Expression of ORF22 partialgene of hepatitis E virus in tomatoes and immunoactivity of expression products显示文摘 | Ma Y Lin SQ Gao Y | 2003 | World J G Astroenterol2003，9，： | 1 |
| 7 | Meffomtin reverses fatty liver disease in obese leptin-deficient mice 显示文摘 | Lin HZ Yang SQ Chuckaree C ctal | 2000 | Nature Med2000，6，8： | 1 |
| 8 | Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia:an experience from a single neonatal intensive care unit显示文摘 | Lin ZL Yu HM Lin J Chen SQ Liang ZQ Zhang ZY | 2006 | J Perinatol2006，26，3： | 1 |
| 9 | Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/ reoxygenation injury 显示文摘 | Zhao HB Lin SQ Liu JH et ol | 2004 | J Pharmacol Sci2004，95，2： | 1 |
| 10 | Metformin's reverses fatty liver disease in obese leptin-deficient mice显示文摘 | Lin HZ Yang SQ Chuckaree C | 2000 | Nature Medicine2000，6，8： | 1 |
| 11 | Serum lipid profile changes dur- ing the menopause transition in Chinese women; a community- based cohort study显示文摘 | Zhou JL Lin SQ Shen Y | 2010 | Menopause2010，17，5： | 1 |
| 12 | Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factoralpha-dependent mechanism显示文摘 | Yang SQ Lin Hz | 1998 | Biochem Biophys Res Commun1998，251，1： | 1 |
| 13 | Leptin regulates proinflammatory immune response 显示文摘 | Loffreda S Yang SQ Lin HZ | 1998 | FASEB J1998，12，1： | 1 |
| 14 | Metformin reverses fatty liver disease in obese,lepfin-deficient mice显示文摘 | Yang SQ Chuckaree C | 2000 | Nat Med2000，6，1： | 1 |
| 15 | Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injury显示文摘 | Zhao HB Lin SQ Liu JH | 2004 | J Pharmacol Sci2004，95，2： | 1 |
| 16 | Metformin reverses fatty liver disease in obese, leptin-deficient mice显示文摘 | Lin HZ Yang SQ Chuckaree C | 2000 | Nat Med2000，6，9： | 1 |
| 17 | The three-wave method for nonlinear evolution equation 显示文摘 | DAI Z D WANG C J LIN SQ | 2010 | NonlSci Lett A2010，1，： | 1 |
| 18 | Vasculature at the Medial Aspect of the Foot and Clinical Application of Flaps Based on It for Forefoot Reconstruction显示文摘 | Zhuang YH Zheng HP Lin SQ | 2011 | Plast Reconstr Surg2011，127，5： | 1 |
| 19 | Vasculature at the medial aspect of the foot and clinical application of flaps based on it for forefoot reconstruction显示文摘 | Zhuang YH Zheng HP Lin SQ | 2011 | Plast Reconstr Surg2011，127，： | 1 |
| 20 | Modified distally based sural neuro-veno-fasciocutaneous flap:anatomical study and clinical applications显示文摘 | Zhang FH Chang SM Lin SQ | 2005 | Microsurgery2005，25，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员