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| 1 | Sterilization and disinfection methods for decellularized matrix materials:Review,consideration and proposal显示文摘Sterilization is the process of killing all microorganisms,while disinfection is the process of killing or removing all kinds of pathogenic microorganisms except bacterial spores.Biomaterials involved in cell experiments,animal experiments,and clinical applications need to be in the aseptic state,but their physical and chemical properties as well as biological activities can be affected by sterilization or disinfection.Decellularized matrix(dECM)is the low immunogenicity material obtained by removing cells from tissues,which retains many inherent components in tissues such as proteins and proteoglycans.But there are few studies concerning the effects of sterilization or disinfection on dECM,and the systematic introduction of sterilization or disinfection for dECM is even less.Therefore,this review systematically introduces and analyzes the mechanism,advantages,disadvantages,and applications of various sterilization and disinfection methods,discusses the factors influencing the selection of sterilization and disinfection methods,summarizes the sterilization and disinfection methods for various common dECM,and finally proposes a graphical route for selecting an appropriate sterilization or disinfection method for dECM and a technical route for validating the selected method,so as to provide the reference and basis for choosing more appropriate sterilization or disinfection methods of various dECM. | Meihan Tao Tianrang Ao Xiaoyan Mao Xinzhu Yan Rabia Javed Weijian Hou Yang Wang Cong Sun Shuang Lin Tianhao Yu Qiang Ao | 2021 | Bioactive Materials2021，6，9： | 2 |
| 2 | The impact of energy-intensive industries on air quality in China’s industrial agglomerations显示文摘Understanding the driving forces of regional air pollution and its mechanism has gained much attention in academic research,which can provide scientific policy-making basis for economy-environment sustainability in China.Being an important energy and industrial base,the North China Plain region has been experiencing severe air pollution.Therefore,understanding the relationship between industrialization and air quality in this region is of great importance for air quality improvement.In this study,the average annual concentrations of SO2,NO2 and PM10 in 47 sample cities at and above the prefecture level in the North China Plain region from 2007 to 2016 were used to illustrate the spatiotemporal characteristics of air pollution within this region.Furthermore,panel data model,panel vector autoregression model,and impulse response function were used to explore the correlation and driving mechanism between energy-intensive industries and regional air quality.The results show that:first,overall air quality improved in the study area between 2007 and 2016,with a significant greater fall in concentration of SO2 than that of NO2 and PM10;second,provincial border areas suffered from severe air pollution and showed an apparent spatial agglomeration trend of pollution;and third,the test results from different models all proved that energy-intensive industries such as the chemical,non-metallic mineral production,electric and thermal power production and supply industries,had a significant positive correlation with concentrations of air pollutants,and indicated an obvious short-term impulse response effect.It concludes that upgradation of industrial structure,especially that of energy-intensive industries,plays a very important role in the improvement of regional air quality,which is recommended to be put in top priority for authorities.Therefore,policies as increasing investments in technological innovation in energy-intensive industries,deepening cooperation in environmental governance between different provinces and cities,and strengthening supervision and entry restrictions are suggested. | ZHANG Xiaoping LIN Meihan WANG Zhenbo JIN Fengjun | 2021 | Journal of Geographical Sciences2021，31，4： | 1 |
| 3 | Fabrication and evaluation of an optimized xenogenic decellularized costal cartilage graft:preclinical studies of a novel biocompatible prosthesis for rhinoplasty显示文摘On account of the poor biocompatibility of synthetic prosthesis,millions of rhinoplasty recipients have been forced to choose autologous costal cartilage as grafts,which suffer from limited availability,morbidity at the donor site and prolonged operation time.Here,as a promising alternative to autologous costal cartilage,we developed a novel xenogeneic costal cartilage and explored its feasibility as a rhinoplasty graft for the first time.Adopting an improved decellularization protocol,in which the ionic detergent was substituted by trypsin,the resulting decellularized graft was confirmed to preserve more structural components and better mechanics,and eliminate cellular components effectively.The in vitro and in vivo compatibility experiments demonstrated that the decellularized graft showed excellent biocompatibility and biosecurity.Additionally,the functionality assessment of rhinoplasty was performed in a rabbit model,and the condition of grafts after implantation was comprehensively evaluated.The optimized graft exhibited better capacity to reduce the degradation rate and maintain the morphology,in comparison to the decellularized costal cartilage prepared by conventional protocol.These findings indicate that this optimized graft derived from decellularized xenogeneic costal cartilage provides a new prospective for future investigations of rhinoplasty prosthesis and has great potential for clinical application. | Shuang Lin Yuanjia He Meihan Tao Aijun Wang Qiang Ao | 2021 | Regenerative Biomaterials2021，8，6： | 1 |
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