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| 1 | Community structure of ammonia-oxidizing bacteria under long-term application of mineral fertilizer and organic manure in a sandy loam soil显示文摘 | Chu HY Fujii T Morimoto S Lin XG Yagi K Hu JL Zhang JB | 2007 | 中国生物学文摘2007，21，6： | 77 |
| 2 | Structural pattern of eastern Himalayan syntaxis in Namjagbarwa and its formation process显示文摘The structural pattern of the eastern Himalayan syntaxis in Namjagbarwa consists of two series of structures with different styles. One series compiles the earlier ductile contractional and lateral-slip deformation system, formed by nearly north-south shortening within the syntaxis, left-lateral and right-lateral slipping along its western and eastern boundaries respectively. They were possibly produced by the indentation of the Indian continent into Asian continent after India-Asia collision. The peak deformation-metamorphic ages in these structures are 62-60 Ma, ~23 Ma and ~13 Ma. The other series is composed of ductile-brittle normal faults distributing concentrically and dipping toward the outsides of Namjagbarwa Peak. They were probably the collapse structures caused by rapid uplift in a later time and the beginning ages for the normal faulting are about 7.3-6.3 Ma. | ZHANG Jinjiang, Jl Jianqing, ZHONG Dalai, DING Lin & HE Shundong1. Department of Geology, Peking University, Beijing 100871, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Correspondence should be addressed to Zhang Jinjiang (email: zhjj@pku.edu.cn) | 2004 | Science China Earth Sciences2004，47，2： | 34 |
| 3 | A new method for judging the computational stability of the difference schemes of nonlinear evolution equations显示文摘For the non-conservative difference schemes of nonlinear evolution equations with aperiodic boundary conditions, taken one-dimensional nonlinear advection equation as an example, a new method for judging the computational stability is given. It is proved to be practical and effective through several numerical examples. The stability criteria obtained by this method are really the necessary conditions of computational stability. | LIN Wantao Jl Zhongzhen WANG Bin YANG Xiaozhong | 2000 | Chinese Science Bulletin2000，45，15： | 18 |
| 4 | Nutritional support teams increase percutaneous endoscopic gastrostomy uptake in motor neuron disease显示文摘AIM:To examine factors influencing percutaneous endoscopic gastrostomy(PEG) uptake and outcomes in motor neuron disease(MND) in a tertiary care centre.METHODS:Case notes from all patients with a confirmed diagnosis of MND who had attended the clinic at the Repatriation General Hospital between January 2007 and January 2011 and who had since died,were audited.Data were extracted for demographics(age and gender),disease characteristics(date of onset,bulbar or peripheral predominance,complications),date and nature of discussion of gastrostomy insertion,nutritional status [weight measurements,body mass index(BMI)],date of gastrostomy insertion and subsequent progress(duration of survival) and quality of life(QoL) [Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised(ALSFRS-R)].In addition,the type of clinician initiating the discussion regarding gastrostomy was recorded as Nutritional Support Team(involved in providing nutrition input viz Gastroenterologist,Speech Pathologist,Dietitian) and other(involved in non-nutritional aspects of patient care).Factors affecting placement and outcomes including length of survival,change in weight and QoL were determined.RESULTS:Case records were available for all 86 patients(49 men,mean age at diagnosis 66.4 years).Thirty-eight patients had bulbar symptoms and 48 had peripheral disease as their presenting feature.Sixty-six patients reported dysphagia.Thirty-one patients had undergone gastrostomy insertion.The major indications for PEG placement were dysphagia and weight loss.Nine patients required immediate full feeding,whereas 17 patients initially used the gastrostomy to supplement oral intake,4 for medication administration and 1 for hydration.Initially the PEG regime met 73% ± 31% of the estimated total energy requirements,increasing to 87% ± 32% prior to death.There was stabilization of weight in patients undergoing gastrostomy [BMI at 3 mo(22.6 ± 2.2 kg/m 2) and 6 mo(22.5 ± 2.0 kg/m 2) after PEG placement compared to weight at the time of the procedure(22.5 ± 3.0 kg/m 2)].However,weight loss recurred in the terminal stages of the illness.There was a strong trend for longer survival from diagnosis among MND in PEG recipients with limb onset presentation compared to similar patients who did not undergo the procedure(P = 0.063).Initial discussions regarding PEG insertion occurred earlier after diagnosis when seen by nutrition support team(NST) clinicians compared to other clinicians.(5.4 ± 7.0 mo vs 11.9 ± 13.4 mo,P = 0.028).There was a significant increase in PEG uptake(56% vs 24%,P = 0.011) if PEG discussions were initiated by the NST staff compared to other clinicians.There was no change in the ALSFRS-R score in patients who underwent PEG(pre 34.1 ± 8.6 vs post 34.8 ± 7.4),although in non-PEG recipients there was a nonsignificant fall in this score(33.7 ± 7.9 vs 31.6 ± 8.8).Four patients died within one month of the procedure,4 developed bacterial site infection requiring antibiotics and 1 required endoscopic therapy for gastric bleeding.Less serious complications attributed to the procedure included persistent gastrostomy site discomfort,poor appetite,altered bowel function and bloating.CONCLUSION:Initial discussion with NST clinicians increases PEG uptake in MND.Gastrostomy stabilizes patient weight but weight loss recurs with advancing disease. | Lin Zhang Leanne Sanders Robert JL Fraser | 2012 | World Journal of Gastroenterology2012，18，44： | 6 |
| 5 | Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats显示文摘Objective To investigate the mechanism of Tojapride,a Chinese herbal formula extract,on strengthening the barrier function of esophageal epithelium in rats with reflux esophagitis(RE).Methods Ten out of 85 SD rats were randomly selected as the sham group(n10),and 75 rats were developed a reflux esophagitis model(RE)by the esophageal and duodenal side-to-side anastomosis.Fifty successful modeling rats were divided into different medicated groups through a random number table including the model,low-,medium-,and high-dose of Tojapride as well as omeprazole groups(n10).Three doses of Tojapride[5.73,11.46,22.92 g/(kg•d)]and omeprazole[4.17 mg/(kg•d)]were administrated intragastrically twice daily for 3 weeks.And the rats in the sham and model groups were administered 10 mL/kg distilled water.Gastric fluid was collected and the supernatant was kept to measure for volume,pH value and acidity.Esophageal tissues were isolated to monitor the morphological changes through hematoxylin-eosin(HE)staining,and esophageal epithelial ultrastructure was observed by transmission electron microscopy.The expressions of nuclear factor kappa-light-chain-enhancer of activated B cells p65(NF-KBp65),κB kinase beta(IKKß),occludin,and zonula occludens-1(ZO-1)in the esophageal tissues were measured by immunohistochemistry and Western blot,respectively.Results The gastric pH value in the model group was significantly lower than the sham group(P<0.05).Compared with the model group,gastric pH value in the omeprazole and medium-dose of Tojapride groups were significantly higher(P<0.05).A large area of ulceration was found on the esophageal mucosa from the model rats,while varying degrees of congestion and partially visible erosion was observed in the remaining groups.Remarkable increase in cell gap width and decrease in desmosome count was seen in RE rats and the effect was reversed by Tojapride treatment.Compared with the sham group,the IKKßlevels were significantly higher in the model group(P<0.05).However,the IKKßlevels were down-regulated after treatment by all doses of Tojapride(P<0.01 or P<0.05).The occluding and ZO-1 levels decreased in the model group compared with the sham group(Ps0.01 or Ps0.05),while both indices were significantly up-regulated in the Tojapride-treated groups(P<0.01 or P<0.05).Conclusions Tojapride could improve the pathological conditions of esophageal epithelium in RE rats.The underlying mechanisms may involve in down-regulating the IKKßexpression and elevating ZO-1 and occludin expression,thereby alleviating the inflammation of the esophagus and strengthening the barrier function of the esophageal epithelium. | YIN Xiao-lan ZHONG Linda LIN Cheng-yuan SHI Xiao-shuang ZHANG Jiao CHEN Zheng-yi CHE Hui MA Xiang-xue TIAN Ya-xin DUAN Yuan-zhi LU Lin Jl Hai-jie ZHAO Ying-pan TANG Xu-dong WANG Feng-yun | 2021 | Chinese Journal of Integrative Medicine2021，27，8： | 4 |
| 6 | 不同血管紧张素转换酶抑制剂与高血压患者整体和病因特异性死亡率的相关性显示文摘血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)已广泛用于治疗高血压,比较不同药物降低死亡率有效性的研究却鲜有报道。方法:选取中国台湾地区全民健康保险数据库中从2004年1月1日至2009年12月31日开始用卡托普利、赖诺普利、依那普利、福辛普利、雷米普利、咪达普利或培哚普利治疗的高血压患者。整体和病因特异性死亡率通过中国台湾地区全民死亡登记来证实。从最初用ACEI开始随访患者直至死亡、退出研究或研究终止(2010年12月31日)。 | Chang CH Lin JW Caffrey JL Wu LC Lai MS | 2015 | 中华高血压杂志2015，23，9： | 2 |
| 7 | Intermedin ( ADM2 ) functions as a pituitary paracrine factor regulating prolctin release 显示文摘 | Chia Lin C Rob G Park Jl | 2005 | Mol Endocrino12005，19，11： | 1 |
| 8 | Down-regulation of L-type calcium channel and sarcopasmic reticular Ca2+-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor,calsequestrin and phospholamban-an insight into the mechanism of atrial electrical remodeling显示文摘 | Lai LP Su MJ Lin JL | 1999 | JACC1999，33，： | 1 |
| 9 | Predictors of clinical recurrence after successful electrical cardioversion of chronic persistent atrial fibrillation :Clinical and electrophysiological observations 显示文摘 | Lin JM Lin JL Lai LP | 2002 | Cardiology2002，97，： | 1 |
| 10 | Mother and fetus both survive from severe paraquat intoxication显示文摘 | Jeng CC Wu CD Lin JL | 2005 | Clin Toxicol(Phila)2005，43，4： | 1 |
| 11 | Tight mechanism correlation betweenheart rate turbulence and baro reflex sensitivity: sequential auto-nomic blockade analysis 显示文摘 | Lin LY Lai LP Lin JL | 2002 | Cardiolvasic Electrophysiol2002，13，： | 1 |
| 12 | Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility factors for noise-induced temporary threshold shift显示文摘 | Lin CY Wu JL Shih TS | 2009 | Hearring Res2009，815，： | 1 |
| 13 | The prevalence, antimicrobial re- sistance and PFGE profiles of Laribacter hongkongensis in retail freshwater fish and edible frogs of southern China 显示文摘 | Feng JL Hu J Lin JY | 2012 | Food Mi- crobiol2012，32，1： | 1 |
| 14 | A study of the process by which a schoolage child adapted to body image changes following openheart surgery显示文摘 | Lin HC Tsai JL | 2006 | Hu Li Za Zhi2006，53，5： | 1 |
| 15 | Tight mechanism correlation between heart rate turbulence and baroreflex sensitivity: sequential autonomic blockade analysis 显示文摘 | Lin LY Lai LP Lin JL | 2002 | J Cardiovase Electrophysiol2002，13，5： | 1 |
| 16 | Expression of artificial microRNAs in transgenic Arabidopsis thaliana confers virus resistance 显示文摘 | Niu QW Lin SS Reyes JL | 2006 | Nature Biotechnology2006，24，： | 1 |
| 17 | Antigen Expression in Xenotransplantation:How Low Must It Co?显示文摘 | Parker W Lin SS Platt JL | 2001 | Transplantation2001，71，2： | 1 |
| 18 | Tight mechanism correlation between heart rate turbulence and baroreflex sensitivity: sequential autonomic blockade analysis 显示文摘 | LIN LY LAI LP LIN JL | 2002 | J Cardiovas Eleetrophyslol2002，13，5： | 1 |
| 19 | Downregulation of angiotensin converting enzyme Ⅱ is associated with pacing-induced sustained atrial fibrillation显示文摘 | Pan CH Lin JL Lai LP | 2007 | FEBS Lett2007，581，： | 1 |
| 20 | Acupuncture for stroke rehabilitation显示文摘 | Wu HM Tang JL Lin XP | 2006 | Cochrane Database Syst Rev2006，，00： | 1 |
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