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| 1 | Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells显示文摘越来越多的研究建议了 type-2 糖尿病导致的 methylglyoxal (MGO ) 与 Parkinson 的疾病(PD ) 有关。然而,很少对分子的机制被知道。在这研究,我们在 neuroblastoma SH-SY5Y 房间探索了 MGO 毒性。MGO 的 Neurotoxicity 被 mitochondrial 膜潜力, malondialdehyde,和 methylthiazoletetrazolium 试金测量。多巴胺, 3,4-dihydroxyphenylacetic 酸(DOPAC ) ,和 1-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (salsolinol ) 的层次被液体 chromatographymass spectrometry/mass spectrometry 检测。酷氨酸 hydroxylase (TH ) 和多巴胺 transporter (DAT ) 的表情被反向的 transcriptase 聚合酶链反应和西方的污点分析检测。当多巴胺, DOPAC,和内长的神经毒素 salsolinol 的层次也增加了时,结果证明 MGO 在 SH-SY5Y neuroblastoma 房间在 TH 和 DAT 表情导致了增加。Aminoguanidine (AG ) 是 MGO 的一个禁止者。AG 能减少,这被发现反应的氧种类(ROS ) 水平由 MGO 导致了,但是不能禁止 TH, DAT 和多巴胺的增加。多巴胺, DOPAC 和 salsolinol 层次的增加能导致高 ROS 和 mitochondrial 损坏。当 MGO 在糖尿病的功课期间被增加时,这研究建议多巴胺引起的 ROS 能贡献 dopaminergic 神经原的损坏。 | Bingjie Xie Fankai Lin Lei Peng Kaleem Ullah Hanyan Wu Hong Qing Yulin Deng | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 2 | Thermodynamic Analysis and Experimental Research of Water-Cooled Small Space Thermoelectric Air-Conditioner显示文摘This paper aims to find a more general analysis method for the refrigeration performance,and to design a high efficiency modular cooling structure of water-cooled plate.A new analysis method,namely current and refrigeration rate density analysis,is proposed.The general refrigeration performance calculation equations are obtained.A finite-time thermodynamic model of the thermoelectric device is established considering Thomson effect.The basic structure of water-cooled thermoelectric air-conditioner is designed and the specific calculation method is given.The influences of input current density,filling factor and heat transfer conditions on refrigeration performance of the thermoelectric air-conditioner are analyzed,which is compared with refrigeration performance of air-cooled thermoelectric air-conditioner.The results show that the maximum refrigeration rate density of the water-cooled thermoelectric air-conditioner is 8.65 k W/m^(2),and the maximum coefficient of performance(COP)is 2.27 in the case of the cooling temperature differenceΔT=5 K.Compared withΔT=5 K,the maximum refrigeration rate density and the maximum COP ofΔT=15 K decreases by 27.98%and 76.65%,respectively.At the filling factorθ=0.43,the refrigeration rate density and COP are 2.57 k W/m~2 and 1.24,respectively.The experimental device of thermoelectric air-conditioner is established to verify the model.The experimental results show that the maximum value of input current and COP is 4 A and 0.95 with the efficient water-cooling method,respectively.The experimental data coincides with the theoretical calculation,which shows the validity of the analysis method and cooling method. | JIANG Fan MENG Fankai CHEN Lin’gen CHEN Zhaojun | 2022 | Journal of Thermal Science2022，31，2： | 2 |
| 3 | Puerarin facilitates Ca 2+ -induced Ca 2+ release triggered by KCl-depolarization in primary cultured rat hippocampal neurons显示文摘 | Fankai Lin Yan Xin Jianghua Wang Liqun Ma Jue Liu Chao Liu Lihong Long Fang Wang You Jin Jun Zhou Jianguo Chen | 2007 | European Journal of Pharmacology2007，，1： | 1 |
| 4 | Strength Acquisition Mechanism of High Temperature Resistant Materials Prepared by Waste Architectural Ceramics显示文摘In order to realize the large-scale and high-value utilization of waste architectural ceramics,high-temperature resistant materials based on waste architectural ceramics were prepared with sodium silicate as the binder,clay/bauxite and metakaolin/bauxite as coating materials,and the cold strength obtaining mechanism was explored.The phase composition,the microstructure and the mechanical properties of the high temperature resistant materials based on waste architectural ceramics were tested and analyzed.The results showed that when the heat treatment temperature was between 110-1000℃,the strength of the samples mainly came from the physical adhesion of sodium silicate and fine powder.When the temperature rose to 1100℃,the strength of the sample was improved since the internal low-melting-point components melted and promoted sintering.The addition of clay and bauxite can effectively enhance the flexural strength of the samples when the heat treatment temperature is 1000℃.When the heat treatment temperature rises from 900 to 1000℃,the flexural strength of the samples will be enhanced owing to the formation of silica alumina spinel and mullite from metakaolin. | HUANG Zhaohui SHI Tengteng LIU Yangai WU Xiaowen LIU Xianjie LIN Fankai LENG Gouqin ZHAN Huasheng LI Yanjing GAO Changhe | 2022 | China's Refractories2022，31，1： | 0 |
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