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| 1 | Some Notes on Large Deviations of Markov Processes | Liming Wu Laboratoire de Mathématiques Appliquées,CNRS-UMR 6620 UniversitéBlaise Pascal,63177,A UBIERE,France and Department of Mathematics,Wuhan University Wuhan,430072 P.R China | 2000 | Acta Mathematica Sinica,English Series2000，16，3： | 2 |
| 2 | Disruption of crosstalk between LX-2 and liver cancer stem-like cells from MHCC97H cells by DFOG via inhibiting FOXM1显示文摘Hepatic stellate cell(HSC)line LX-2 is activated by liver cancer stem-like cells(LCSLCs)and produces various cytokines that make up most of the hepatocellular carcinoma(HCC)microenvironment.The new genistein derivative,7-difluoromethoxyl-5,4-dirboctylgenistein(DFOG),shows anticancer effects in multiple malignancies by controlling forkhead box M1(FOXM1).In this study,we aimed to assess whether DFOG disrupts the crosstalk between human HSC LX-2 cells and LCSLCs.Distinct gen erations of MHCC97H-derived spheres were obtained with the sec ond generation considered as LCSLCs which displayed enhanced self-renewal ability and elevated expression levels of CD133,CD44,and EpCAM proteins,as well as tumorigenicity,as revealed by colony formation assay in vitro and tumorigenicity assay in vivo.LX-2 and MHCC97H cells were co-cultured with/without DFOG(1,5,and 10 pM,respectively)using the transwell system.FOXM1 overexpression and/or knockdown were employed for mechanistic investigations.Our results suggested that Co-CM promoted LX-2 cell transformation into liver cancer-associated HSCs.Meanwhile,FOXM1 was up-regulated and the level of hepatocyte growth factor(HGF)was in creased in LX-2 cells and in the super nata nt after Co-CM stimulati on.Sphere and colony formation abilities in MHCC97H cells,and protein levels of CD133r CD44,and EpCAM,were also markedly elevated.DFOG dose-dependently inhibited the above effects,similar to FOXM1 knockdown in LX-2 cells.FOXM1 overexpression reversed the inhibitory effects of DFOG or FOXM1 knockdown or both on LX-2 cell activation and LCSLC feature induction in MHCC97H cells by LCSLC/LX-2 co-culture.This study demonstrated that DFOG disrupts the crosstalk between HSCs and LCSLCs to suppress LCSLC features via dowrrregulating FOXM1 expression and reducing HGF secretion in HSCs. | A Chen Chang Xu Yimin Luo Lihua Liu Kun Song Guangqi Deng Mengjie Yang Jianguo Cao Liming Yuan Xiang Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 2 |
| 3 | 显示文摘 | Ying Liming Bruckbauer A Rothery A M | 2002 | Anal Chem2002，74，： | 1 |
| 4 | On strategies for imbalanced text classification using SVM: a comparative study显示文摘 | SUN A X LIME E LIU Y | 2009 | Decision Support Systems2009，48，1： | 1 |
| 5 | Spot the Difference:Consumer Responses towards Counterfeits显示文摘 | ANG S H CHENG P S LIME A C | 2001 | Journal of Consumer Marketing2001，18，3： | 1 |
| 6 | Efficacy of lignocaine in alleviating potassium chloride infusion pain显示文摘 | LIME T KHOO S T TWEED W A | 1992 | Anaesth Intensive Care1992，20，2： | 1 |
| 7 | On the dynamics of a spherical scaffold in rotating bioreactors显示文摘 | RAMIREZ L LIME A COIMBRA C | 2003 | Biotechnology and Bioengineering2003，84，3： | 1 |
| 8 | Performance measurement framework for hierarchical text classification显示文摘 | SUN A X LIME P NG W K | 2003 | Journal of the American Society for Information Science and Technology2003，54，11： | 1 |
| 9 | On strategies for imbalanced text classification using SVM: a comparative study 显示文摘 | SUN A LIME P LIU Y | 2009 | Decision Support Systems2009，48，1： | 1 |
| 10 | Grazing and utilization of chroococcoid cyanobacteria and heterotrophic bacteria by protozoa in laboratory cultures and a coastal plankton community显示文摘 | CARON D A LIME L MICELI G | 1991 | Mar Ecol Prog Ser1991，76，3： | 1 |
| 11 | Blocking reduction strategies in hierarchical text classification显示文摘 | SUN A LIME P NG W K | 2004 | IEEE Trans on Knowledge and Data Engineering2004，16，10： | 1 |
| 12 | Suitability of novel galactomannans as edible coatings for tropical fruits显示文摘 | CREQUE1RA M A LIME A M TEIXEIRA J A | 2009 | Journal of Food Engineering2009，94，34： | 1 |
| 13 | Closure, stability and iterated line graphs with a 2-factor 显示文摘 | Saito A Xiong Liming | 2009 | Discrete Math2009，309，16： | 1 |
| 14 | Application of a molecular beacon real-time PCR technology to detect Salmonella species contaminating fruits and vegetables 显示文摘 | Samantha Hu Liming Arvind A Bhagwat | 2004 | International Journal of Food Microbiology2004，，95： | 1 |
| 15 | Increaseed K^+ efflux And apoptosis induced by the potassium channel modulatory protein KChAP/PIAS313 In prostate cancer cells显示文摘 | ARBARA A WIBLE LIMING WANG YURI A KURYSHEV | 2002 | JBC Online2002，277，17： | 1 |
| 16 | CFD modeling of spontaneous heating in a large-scale coal chamber显示文摘 | YUAN Liming Smith A C | | 0，，： | 1 |
| 17 | Mechanism and microstructure of oxide fluxes for gas tungsten arc we- lding of magnesium alloy显示文摘 | Liu Liming Zhang Zhaodong Song Gang et a/ | 2007 | metallurgical and materials transactions A2007，38，3： | 1 |
| 18 | Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselecrive synthesis of diverse quercetin glucosides 显示文摘 | LIME K ASHFORD D A HOU B | 2004 | Biotechnol Bioeng2004，87，5： | 1 |
| 19 | Treatment of resistantperitonitis in continuous ambulatory peritoneal dialysis withintraperitoneal urokinase: a double-blind clinical trial 显示文摘 | limes A Burden R P Finch R G | 1994 | NephrolDial Transplant1994，9，7： | 1 |
| 20 | A cation-exchange material for protein separations based on grafting of thiol-terminated sulfopropyl methacrylate telomers onto hydrophilized monodisperse divinylbenzene particles显示文摘 | NORDBORG A LIME F SHCHUKAREV A | 2008 | Journal of separation science2008，31，12： | 1 |
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