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| 1 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 2 | Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics. | Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart | 2019 | Animal Models and Experimental Medicine2019，2，4： | 3 |
| 3 | Robust adaptive beamforming based on covariance matrix reconstruction for look direction mismatch显示文摘 | Mallipeddi R Lie J P Suganthan P N | 2011 | Progress in Electromagnetics Research Letters2011，25，： | 1 |
| 4 | Use of High-pressure Processing for Oyster Shucking and Shelf-life Extension 显示文摘 | lie H Adams R M Farkas D F | 2002 | Journal of Food Science2002，67，2： | 1 |
| 5 | Expression of p27,p21and p16 protein in early squamous cervical cancer and its relation to prognosis显示文摘 | Van de Putte G Holm R Lie AK | 2003 | Gynecol Oncol2003，89，1： | 1 |
| 6 | Fine grid tidal modeling of the Yellow and East China Seas显示文摘 | KANG S K LEE S R LIE H J | 1998 | Continental Shelf Research1998，18，： | 1 |
| 7 | How temperature affects development and reproduction in spiders: a review 显示文摘 | Lie D Q Jackson R R | 1996 | J Therm Biol1996，，4： | 1 |
| 8 | Long-term medical and social conse- quences of preterm birth 显示文摘 | Moster D Lie R T Markestad T | 2008 | N Engl J Med2008，359，3： | 1 |
| 9 | Long-term results of allogeneic bone marrow transplantation for 108 aduh patients with acute lym- phoblastic leukemia:favorable outcome with BMT at first remission and HLA-matched unrelated donor 显示文摘 | China CS Lie AK Liang R | 2007 | Bone Marrow Transplant2007，40，4： | 1 |
| 10 | Clinicopathological featur--es and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantationJ bone显示文摘 | Leun g A Y Mak R Lie AK | 2002 | Marrow Transplant2002，29，6： | 1 |
| 11 | Method to calculate the fire resistance of reinforced concrete columns with rectangular cross section显示文摘 | Lie T T Irwin R J | 1993 | ACI Structural Journal1993，90，1： | 1 |
| 12 | Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion显示文摘 | LIE J DE CROM R VAN GENT T | 2002 | J Lipid Res2002，43，11： | 1 |
| 13 | Fire resistance of steel columns filled with bar-reinforced concrete显示文摘 | Lie T T Kodur V K R | 1996 | Journal of Structural Engineering1996，122，1： | 1 |
| 14 | Fire resistance of steel columns filled with bar-reinforced concrete 显示文摘 | LIE T T KODUR V K R | 1996 | Journal of Structural En- gineering ASCE1996，122，1： | 1 |
| 15 | Arabidopsis cuticular waxes: Advances in synthesis, export and regulation显示文摘 | Amélie Bernard Jér?me Joubès | 2013 | Progress in Lipid Research2013，，1： | 1 |
| 16 | Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins显示文摘 | LIE J DE CROM R VAN GENT T | 2004 | J Lipid Res2004，45，5： | 1 |
| 17 | Visual simulation of shallow-water waves显示文摘 | HAGEN T R HJELMERVIK J M LIE K-A | 2005 | Simul Model Pract Theory2005，13，8： | 1 |
| 18 | Fire resistance of circular steel columns filled with fibre-reinforced concrete 显示文摘 | KODUR V K R LIE T T | 1996 | Journal of Structural Engineering ASCE1996，122，7： | 1 |
| 19 | Co-Authorship Networks and Research Impact: A Social Capital Perspective 显示文摘 | LIE Y LIAO C H YEN H R | 2013 | Research Policy2013，42，9： | 1 |
| 20 | Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis 显示文摘 | Van de Putte G Holm R Lie AK | 2003 | Gynecol Oncal2003，，89： | 1 |
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