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| 1 | Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin显示文摘AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth. METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice. Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining. RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ± 52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer. | Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu | 2007 | World Journal of Gastroenterology2007，13，34： | 15 |
| 2 | 长期食用含糖和人工甜味剂的饮料与美国成年人死亡风险的关系显示文摘摄入含糖饮料(sugar-sweetened beverages,SSB)或含人工甜味剂饮料(artificially sweetened beverages,ASB)是否与死亡风险相关,这关乎公共卫生利益。研究者分析了卫生专业人员随访研究(1986-2014年)中男性37 716人和护士健康研究(1980-2014年)中女性80 647人(基线无慢性病)的SSB和ASB的消费与总死亡率和病因特异性死亡率之间的关系。应用Cox比例风险回归估计风险比和95%CI。结果显示,在随访3415564人年期间,研究者记录了36436例死亡,其中心血管病死亡7896例,癌症死亡12380例。 | 刘青(译) 叶鹏(摘、审校) Malik VS Li Y Pan A De Koning L Schernhammer E Willett WC Hu FB | 2019 | 中华高血压杂志2019，27，5： | 9 |
| 3 | Derivation of hypermethylated pluripotent embryonic stem cells with high potency显示文摘天真的 hypomethylated 胚胎的 pluripotent 干细胞(转换字符) 离胚囊的 preimplantation epiblast 发展地最靠近,与潜力到贡献所有胚胎的纸巾和 germline,除了在妄想的胚胎的胚胎外的纸巾。由对比,类似于 postimplantation epiblast 的 epiblast 干细胞(EpiSCs ) 是相对更多的 methylated 和表演为 chimerism 的一个有限潜力。第一次,这里,我们在 pluripotent 房间以外发展地揭示先进 pluripotent 干细胞(ASC ) ,它是在内部房间团中,但是与更高的力量比 EpiSCs。因此,单个 ASC 在怪物很高效地作出贡献到胎儿, germline,蛋黄囊和胎盘的迷宫。因为他们是,发展地,更多进展了, ASC 不贡献 trophoblast。ASC 在与 Activin A 和基本成纤维细胞生长因素补充的化学上定义的媒介在二个步骤从胚囊被导出,在包含 ActA, BMP4, CHIR99021 和白血病的 ABCL 媒介由 culturing 列在后面禁止的因素。尤其是, ASC 与天真的 pluripotency 基因,以及 mesodermal 的表示展出不同 transcriptome 体的基因;Eomes,时代, Tdgf1, Evx1, hand1, Wnt5a 和不同重复元素。到 ASC 的确定的转换字符的变换也是可完成的。重要地, ASC 作为与 hypomethylated 相比展出稳定的 hypermethylated epigenome 和主要未经触动的印记胚囊和天真的转换字符的内部房间质量。ASC 的性质建议他们以在 pluripotency 的天真、告知的状态之间的一个中间的细胞的状态代表房间。 | Siqin Bao Walfred WC Tang Baojiang Wu Shinseog Kim Jingyun Li Lin Li Toshihiro Kobayashi Caroline Lee Yanglin Chen Mengyi Wei Shudong Li Sabine Dietmann Fuchou Tang Xihe Li | 2018 | Cell Research2018，28，1： | 4 |
| 4 | Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals 显示文摘 | Li WC Kuszak JR Dunn K | 1995 | J Cell Biol1995，130，1： | 2 |
| 5 | Lens epithelial cells apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals显示文摘 | Li WC Kuszak JR Dunn K | 1995 | J Cell Biol1995，130，： | 2 |
| 6 | Isolation and culture of adult mouse hepatocytes显示文摘 | Li WC Ralphs KL Tosh D | 2010 | Methods Mol Biol2010，633，： | 1 |
| 7 | Novel porous solids for carbon dioxide capture显示文摘 | Hao G P Li WC Lu A H | 2011 | Journal of Materials Chemistry2011，21，18： | 1 |
| 8 | Matrilysin(matrix metalloproteinase- 7) mediates E-cadherin ectodomain shedding in injured lung ep- ithelium显示文摘 | McGuire JK Li Q Parks WC | 2003 | Am J Patho12003，162，： | 1 |
| 9 | The effect of blocking anutritional pathway to the intervertebral disc in the dog model 显示文摘 | Hutton WC Murakami H Li J | 2004 | J Spinal Disord Tech2004，17，1： | 1 |
| 10 | RGD- conjugated Gold nanorods induce radiosensitization in melanoma cancer cells by downregu- lating alpha(v)beta(3) expression显示文摘 | Xu WC Luo T Li P | 2012 | Int J Nanomedicine2012，7，： | 1 |
| 11 | Lens epithelial cell apoptasis appears to be a common cellar basis for non-con- genital cataract development in humans and animals 显示文摘 | LI WC KUSZAK JR DUNN K | 1995 | J Cell Biol1995，130，1： | 1 |
| 12 | Nucleophosmin mutations in de novo acute myeloid leukemia:the age-dependent incidences and the stability during disease evolution显示文摘 | Chou WC Tang JL Lin LI | 2006 | Cancer Res2006，66，： | 1 |
| 13 | Clinical significance of regulatory T cells and CD8+effector populations in patients with human endometrial carcinoma显示文摘 | Chang WC Li CH Huang SC | 2010 | Cancer2010，116，24： | 1 |
| 14 | Precancerous gastric lesions in a population at high risk of stomach cancer显示文摘 | You WC Blot WJ Li JY | 1993 | Cancer Res1993，53，1： | 1 |
| 15 | Lens epithelial cell apoptosis appears to be a common cellular basis for non--congenital cataract development in humans and animals显示文摘 | Li WC Kuszak JR Dunn K | 1995 | J Cell Biol1995，130，： | 1 |
| 16 | C-glycosylflavones from stellaria media显示文摘 | Hu YM Ye WC Li Q | 2006 | Chin J Nat Med2006，4，6： | 1 |
| 17 | A Chinese adolescent girl with Fechtner-like syndrome显示文摘 | Leung TF Tsoi WC Li CK | 1998 | Acta Paediatr1998，87，： | 1 |
| 18 | Characteristics of primary osteomyelitis children in a medical center in Taipei 显示文摘 | Yeh TC Chiu NC Li WC | 2005 | -2002 J Formos Med As- soc2005，104，1： | 1 |
| 19 | Poly ( 1 -lactide) -vitamin E TPGS nanoparticles enhanced the cytotoxicity of doxorubicin in drug-resistant MCF-7 breast cancer cells 显示文摘 | Li PY Lai PS Hung WC | 2010 | Biomacromolecules2010，11，10： | 1 |
| 20 | Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals 显示文摘 | Li WC Kuszak JR Dunn K | 1995 | J Cell Biol1995，130，1： | 1 |
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