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| 1 | PD-1 Involvement in Peripheral Blood CD8+T Lymphocyte Dysfunction in Patients with Acute-on-chronic Liver Failure显示文摘Background and Aims:Programmed cell death-1(PD-1)plays an important role in downregulating T lymphocytes but the mechanisms are still poorly understood.This study aimed to explore the role of PD-1 in CD8^(+)T lymphocyte dysfunction in hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).Methods:Thirty patients with HBV-ACLF and 30 healthy controls(HCs)were recruited.The differences in the numbers and functions of CD8^(+)T lymphocytes,PD-1 and glucose transporter-1(Glut1)expression from the peripheral blood of patients with HBV-ACLF and HCs were analyzed.In vitro,the CD8^(+)T lymphocytes from HCs were cultured(HC group)and the CD8^(+)T lymphocytes from ACLF patients were cultured with PD-L1-IgG(ACLF+PD-1 group)or IgG(ACLF group).The numbers and functions of CD8^(+)T lymphocytes,PD-1 expression,glycogen uptake capacity,and Glut1,hexokinase-2(HK2),and pyruvate kinase(PKM2)expression were analyzed among the HC group,ACLF group and ACLF+PD-1group.Results:The absolute numbers of CD8^(+)T lymphocytes in the peripheral blood from patients with HBVACLF were lower than in the HCs(p<0.001).The expression of PD-1 in peripheral blood CD8^(+)T lymphocytes was lower in HCs than in patients with HBV-ACLF(p=0.021).Compared with HCs,PD-1 expression was increased(p=0.021)and Glut1 expression was decreased(p=0.016)in CD8^(+)T lymphocytes from the HBV-ACLF group.In vitro,glycogen uptake and functions of ACLF CD8^(+)T lymphocytes were significantly lower than that in HCs(p=0.017;all p<0.001).When PD-1/PD-L1 was activated,the glycogen uptake rate and expression levels of Glut1,HK2,and PKM2 showed a decreasing trend(ACLF+PD-1 group compared to ACLF group,all p<0.05).The functions of CD8^(+)T lymphocytes in the ACLF+PD-1 group[using biomarkers of Ki67,CD69,IL-2,interferon-gamma,and tumor necrosis factor-alpha-were lower than in the ACLF group(all p<0.05).Conclusions:CD8^(+)T lymphocyte dysfunction is observed in patients with HBV-ACLF.PD-1-induced T lymphocyte dysfunction might involve glycolysis inhibition. | Xiaoshuang Zhou Yidong Li Yaqiu Ji Tian Liu Ninghui Zhao Jiefeng He Jia Yao | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 2 |
| 2 | Fabrication of Regular Hierarchical Structures with Superhydrophobic and High Adhesion Performances on a 304 Stainless Steel Surface via Picosecond Laser显示文摘Hierarchical structures significantly influence the development of metal surface wettability.In this study,three kinds of hierarchical structures fbimed by the superimposition of different nanoscale(quasi-)periodic structures on micro-column arrays were fabricated on 304 stainless steel surfaces via picosecond laser irradiation.Scanning Electron Microscope(SEM)and Confocal Laser Scanning Microscope(CLSM)were used to characterize the created hierarchical structures.An optical contact angle meter was used to analyse the wetting performances.The results show that the surfaces of these fabricated samples have superhydrophobic properties and strong adhesion per formances,which can be attributed to the formation of hierarchical structure that causes a reduction in the liquid-solid contact area and the change in the direction of surfece tension.By controlling the dimensionof the nanotextures on the micro-column arrays,the hydrophobic property of 304 stainless steel surfaces can be greatly improved. | Chenbin Ma Min Kang Xingsheng Wang Ninghui Li Wei Hong Chenyu Li An Yang | 2019 | Journal of Bionic Engineering2019，16，5： | 2 |
| 3 | Delegation Logic:A Logic-based Approach to Distributed Authorization显示文摘 | Ninghui Li Benjamin N G Feigenbaum J | 2003 | ACM Transactions on Information and System Security2003，6，1： | 1 |
| 4 | Experimental research about the role of activating water-vapor in the De SO2technology from flue gas with PPCP显示文摘 | WU Yan LI Jie WANG Ninghui | 2000 | IEEE Industry Applications Conference2000，，： | 1 |
| 5 | Industrial experiments on desulfurization of flue gases by pulsed corona induced plasma chemical process显示文摘 | Wu Yan Li Jie Wang Ninghui | 2003 | Journal of Electrostatics2003，57，34： | 1 |
| 6 | Study on Increasing the SO2 Removal Efficiency with the Radicals Produced by H2O in Pulse Discharge Plasma Process显示文摘 | Wu Yan Li Jie Wang Ninghui | 2001 | Jpn J Appl Phys:Part 22001，40，8： | 1 |
| 7 | Delegation logic: A logic-based approach to distributed authorization显示文摘 | LI NINGHUI GROSOF B N FEIGENBAUM J | 2003 | ACM Transaction on Information and System Security2003，6，1： | 1 |
| 8 | OACerts:oblivious attribute certificates 显示文摘 | Li Jiangtao Li Ninghui | 2006 | IEEE Transactions on Dependable and Secure Computing2006，3，4： | 1 |
| 9 | Industrial experiments on desulfurization of flue gas by pulsed corona induced plasma chemical process显示文摘 | Yan Wu Jie Li Ninghui Wang | 2003 | Journal of Electrostatics2003，57，34： | 1 |
| 10 | Industrial experiments on desulfurization of flue gases by pulsed corona induced plasma chemical process显示文摘 | Yan Wu Jie Li Ninghui Wang | 2003 | Journal of Electrostatics2003，57，： | 1 |
| 11 | Distributed credential chain discovery in trust management显示文摘 | LI NINGHUI WINSBOROUGH W H MITCHELL J C | 2003 | Journal of Computer Security2003，11，1： | 1 |
| 12 | Slicing: A new approach for privacy preserving data publishing 显示文摘 | Ninghui Li Jian Zhang Molloy I | 2009 | 1EEE Transactions onKnowledge and Data Engineering2009，24，3： | 1 |
| 13 | Towards optimal k-anonymization显示文摘 | Tiancheng Li Ninghui Li | 2008 | Data and Knowledge Engineering2008，65，1： | 1 |
| 14 | Closeness: a new privacy measure for data publishing显示文摘 | Li Ninghui Li Tiancheng Venkatasubramanian S | 2010 | IEEE Trans on Knowledge and Data Engineering2010，22，7： | 1 |
| 15 | Security analysis in role- based access control显示文摘 | LI Ninghui TRIPUNITARA M V | 2006 | ACM Transactions on Information and System Security2006，9，4： | 1 |
| 16 | Distributed cre- dential chain discovery in trust management显示文摘 | Li Ninghui Winsborough W H Mitchell J C | 2003 | Joumal of Computer Security2003，11，1： | 1 |
| 17 | Security analysis in role-based access control显示文摘 | Li Ninghui Tripunitara M | 2006 | ACM Trans on Information and System Security2006，9，4： | 1 |
| 18 | On mutually exclusive roles and seperation-of-duty显示文摘 | LI NINGHUI TRIPUNITARA M V BIZRI Z | 2007 | ACM Transactions on Information and System Security2007，10，2： | 1 |
| 19 | Beyond proof of compliance: Security and availability analysis in trust management 显示文摘 | Ninghui Li John C Mitchell William H Wingsborough | 2005 | Journal of ACM2005，52，3： | 1 |
| 20 | A critique of the ANSI standard on role-based access control显示文摘 | Li Ninghui Ji Won Byun Bertino E | 2007 | IEEE Security & Privacy2007，5，6： | 1 |
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