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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Generalized charts ofenergy storage effectiveness for thermocline heat storagetank design and calibration显示文摘 | Li P Lew J V Karaki W | 2011 | Solar Energy2011，85，9： | 1 |
| 3 | Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain显示文摘 | Sara Ekmark-Lewén Anders Lewén Charlotte Israelsson Gui Lin Li Mohammad Farooque Yngve Olsson Ted Ebendal Lars Hillered | 2010 | Restorative Neurology and Neuroscience2010，，3： | 1 |
| 4 | Comparing the urea re- duction ratio and the urea product as outcome-based measures of hemodialysis dose 显示文摘 | Li Z Lew NL Lazarus JM | 2000 | Am J Kidney Dis2000，35，4： | 1 |
| 5 | CFD study on flow distribution uniformity in fuel distributors having multiple structural bifurcations of flow channels 显示文摘 | Liu H Li P Lew J V | 2010 | International Journal of Hydrogen Energy2010，35，17： | 1 |
| 6 | Magnetic nanoscale dots on colloid crystal surfaces显示文摘 | Li S P Lew W S Xu Y B | 2000 | Appl Phys Lett2000，76，： | 1 |
| 7 | CFD study on flow distribution uniformity in fuel distributors having multiple structural bifurcations of flow channels显示文摘 | Liu H Li P W Van Lew J | 2010 | International Journal of Hydrogen Energy2010，35，17： | 1 |
| 8 | Generalized charts of for thermocline heat storage tank design and calibration显示文摘 | Li P Lew J V Karaki W energy storage effectiveness | 2011 | Solar Energy2011，85，9： | 1 |
| 9 | A method for designing broad-band Microstrip antennas in multi- layered planar structures显示文摘 | LIU Zhangfa KOOI Pangshyan LI Lewe | 1999 | IEEE Transactions on Antennas and Propagation1999，47，9： | 1 |
| 10 | Diallyl trisulfide inhibits angiogenic features of human umbilical vein endothelial cells by causing Akt inactivation and down-regulation of VEGF and VEGFR-2 显示文摘 | Xiao D Li M Herman-Antosiewicz A Xiao H Lew KL Zeng Y ctal | 2006 | Nutr Cancer2006，55，1： | 1 |
| 11 | Metabolism of 1-acyl-2-oleoyl-sn-glycero-3-phosphoethanolamine in castor oil biosythesis显示文摘 | LI J T LEW K M CHEN J M | 2000 | Lipids2000，35，5： | 1 |
| 12 | Magellan:a cognitive map-based model of human wayfinding显示文摘 | MANNING J R LEW T F LI N | 2014 | Journal of Experimental Psychology2014，143，3： | 1 |
| 13 | Is B-lineage acute lymphoblastic leukemia with a mature phenotype and L1 morphology a precursor B-lymphoblastic leukemia/lymphoma or Burkitt leukemia/lymphoma·显示文摘 | Li S Lew G | 2003 | Arch Pathol Lab Med2003，127，10： | 1 |
| 14 | Comparing the urea reduction ratio and the urea product as outcome-based measures of hemodialysis does显示文摘 | Li Z Lew N L Lazarus J M | 2000 | Am J Kidney Dis2000，35，4： | 1 |
| 15 | Generalized charts of energy storage effectiveness for thermocline heat storage tank design and calibration 显示文摘 | Li P Lew J V Karaki W | 2011 | Solar Energy2011，85，9： | 1 |
| 16 | The Hong Kong progressive lens myopia control study: design and main fingings 显示文摘 | EDWARDS MH LI RW LAM CS LEW JK YU BS | 2002 | Invest Ophthalmol Vis Sci2002，43，9： | 1 |
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