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| 1 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 2 | Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial显示文摘Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease. | CHENG Chung-wah ZHANG Li ZHAO Chen ZHONG Linda LD SHI Li-jie DAI Liang ZHENG Rui CHEN Jing LI Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 3 |
| 3 | Standard Protocol Items for Clinical Trials with Traditional Chinese Medicine 2018: Recommendations, Explanation and Elaboration(SPIRIT-TCM Extension 2018)显示文摘Traditional Chinese Medicine(TCM) is one of the oldest systems of medicine. More and more attention has been paid to TCM application, but the variable quality of clinical trials with TCM impedes its widespread acceptance. The Standard Protocol Items: Recommendations for Interventional Trials(SPIRIT) 2013 Statement has established guidelines for designing clinical trials to ensure that the trial results are accurate and reliable. However, there are difficulties when applying SPIRIT 2013 Statement to trials with TCM, due to the unique theory and the characteristic of TCM intervention. An Extension to the original SPIRIT was developed to ensure the quality of trial design with TCM. As Chinese herbal formulae, acupuncture and moxibustion are common and representative interventions in TCM practice, the executive working group determined that the SPIRIT-TCM Extension focus on these three interventions. Extension was developed through initiation, 3 rounds of Delphi consensus survey, and finalizing expert meeting. Seven items from the SPIRIT 2013 Statement were modified, namely, 'title', 'background and rationale', 'objectives', 'eligibility criteria', 'interventions', 'outcomes', and 'data collection methods'. The Extension includes the introduction of the concept of TCM pattern and 3 major TCM interventions, with examples and explanations. The SPIRIT-TCM Extension 2018 provides suggestion for investigators in designing high quality TCM clinical trials. It is expected that wide dissemination and application of this extension ensure continuous improvement of TCM trial quality throughout the world. | DAI Liang CHENG Chung-wah TIAN Ran ZHONG Linda LD LI You-ping LYU Ai-ping CHAN An-wen SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，1： | 2 |
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| 5 | Estimation and projection of therational profile of cancer mortality in China:1991-2005显示文摘 | Yang L Parkin DM LI LD et a1 | 2008 | Br JCancer2008，90，11： | 1 |
| 6 | Inducible expression of functionalmu opioid receptors in murine dendritic cells显示文摘 | Li ZH Chu N Shan LD | 2009 | J NeuroimmunePharmacol2009，4，3： | 1 |
| 7 | Post-stroke hypother- mia provides neuroprotection through inhibition of AMP- activated protein kinase 显示文摘 | Li J Benashski S McCullough LD | 2011 | J Neurotrauma2011，28，7： | 1 |
| 8 | A varicella outbreak in a school with high one-dose vaccination coverage, Beijing, China显示文摘 | Lu L Suo LD Li J | 2012 | Vaccine2012，30，： | 1 |
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| 12 | Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice显示文摘 | Li XX Bek M Asico LD | 2001 | Hypertension2001，38，： | 1 |
| 13 | Genome wide association study of esophageal squamous cell carcinoma in Chinese sub- jects identifies susceptibility loci at PLCE1 and C20orf54显示文摘 | Wang LD Zhou FY Li XM | 2010 | Nat Genet2010，42，9： | 1 |
| 14 | Using mesoporous carbon electrodes for brackishwater desalination显示文摘 | Zou LD LI L X Song H H | 2008 | Water Resarch2008，42，： | 1 |
| 15 | Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty disease 显示文摘 | Hong XZ Li LD Wu LM | 2007 | Clin Exp Pharmacol Physiol2007，34，12： | 1 |
| 16 | DHA does not protect ELOVL4 transgenic mice from retinal degeneration显示文摘 | Li F Marchette LD Brush RS | 2009 | Mol Vis2009，15，： | 1 |
| 17 | Somatostatincell processes as pathways for paracrine secretion 显示文摘 | Larsson LI Goltermann N Magistrls LD | 1979 | Science1979，205，28： | 1 |
| 18 | Estimation and projec-tion of the national profile of cancer mortality in China:1991-2005显示文摘 | Yang L Parkin DM Li LD | 2004 | Br J Cancer2004，90，11： | 1 |
| 19 | Enzyme induction and acute endocrine effects in prepubertal female rats receiving environmental PCB/PCDF/PCDD mixtures 显示文摘 | Li MH Hansen LD | 1996 | Environ Health Perspectives1996，104，： | 1 |
| 20 | Estimation and projectionof the national profile of cancer mortality in China:1991-2005显示文摘 | Yang L Parkin DM Li LD | 2004 | BrJ Cancer2004，90，11： | 1 |
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