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| 1 | The Genesis Mechanism of the Mantle Fluid Action and Evolution in the Ore-Forming Process: A Case Study of the Laowangzhai Gold Deposit in Yunnan, China显示文摘Based on petrological studies of the wall rocks, mineralizing rocks, ores and veins from the Laowangzhai gold deposit, it is discovered that along with the development of silication, carbonation and sulfidation, a kind of black opaque ultra-microlite material runs through the spaces between grains, fissures and cleavages. Under observations of the electron microprobe, scanning electronic microscopy and energy spectrum, this kind of ultra-microlite material is confirmed to consist of ultra microcrystalline quartz, silicate, sulfides and carbonates, as well as rutile, scheelite and specularite (magnetite), showing characters of liquation by the analyses of SEM and energy spectrum. The coexistence of immiscibility and precipitating co-crystallization strongly suggests that the mineralizing fluid changed from the melt to the hydrothermal fluid. Combined with the element geochemical researches, it is realized that the ultra-microlite aggregate is the direct relics of the mantle fluid behaving like a melt and supercritical fluid, which goes along with the mantle-derived magma and will escape from the magma body at a proper time. During the alteration process, the nature of the mantle fluid changed and it is mixed with the crustal fluid, which are favorable for mineralization in the Loawangzhai gold deposit. | LIU Xianfan LI Chunhui LU Qiuxia DENG Biping SONG Xiangfeng ZHAO Fufeng CHU Yating XIAO Jixiong YI Liwen HUANG Yupeng | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 13 |
| 2 | C^2G^2FSnake: automatic tongue image segmentation utilizing prior knowledge显示文摘Extraction of the tongue body from digital images is essential for automated tongue diagnoses in traditional Chinese medicine. This paper presents a fully automated active contour initial method that utilizes prior knowledge of the tongue shape and its location in tongue images. Then colorspace information is introduced to control curve evolution. Combining the geometrical Snake model with the parameterized GVFSnake model, a novel approach for automatic tongue segmentation: C2G2FSnake (color control-geometric & gradient flow Snake) is proposed. This method increases the curve velocity but decreases the complexity. C2G2FSnake greatly extends practical usage to tongue segmentation, at the same time increasing the precision. Compared with other state-of-the-art works using different images of tongue color, C2G2FSnake realizes automatic tongue segmentation with greatly improved accuracy. | SHI MiaoJing LI GuoZheng LI FuFeng | 2013 | Science China(Information Sciences)2013，56，9： | 12 |
| 3 | Clinical classification and gene mutation of Chinese probands with Charcot-Marie-Tooth disease Analysis of 57 cases显示文摘Charcot-Marie-Tooth(CMT) disease is the most common inherited peripheral neuropathic disorder.CMT is clinically and genetically heterogeneous.To date,27 genes associated with the disease have been cloned.The present study carried out clinical classification according to clinical,electrophysiological and pathological features,conducted inheritance classification according to inheritance patterns,and performed mutation analysis of 13 CMT disease genes(PMP22,CX32,HSPB1,MNF2,MPZ,HSPB8,GDAP1,NFL,EGR2,SIMPLE,RAB7,LMNA,MTMR2) in 57 Chinese probands with CMT.Five cases of AD-CMT1 and 13 cases of sporadic CMT1 were diagnosed as CMT1A;five cases of X-CMT1,one case of X-CMT2 and one case of sporadic CMT1 were diagnosed as CMTX1;four cases of AD-CMT2 were diagnosed as CMT2F;one case of AD-CMT2 and one case of sporadic CMT2 were diagnosed as CMT2A2;one case of AD-CMT2 was diagnosed as CMT2L;one case of AD-CMT2 was diagnosed as CMT2J;one case of AR-CMT1 was diagnosed as CMT4A.Among the 57 CMT probands,seven genotypes were determined among 34 patients,with a detection rate of 59.6%.The results indicated that the clinical classification and inheritance classification are indispensable for selecting potential disease genes for mutation detection,and for efficient molecular diagnosis. | Ruxu Zhang Xiaobo Li Xiaohong Zi Shunxiang Huang Fufeng Zhang Kun Xia Qian Pan Beisha Tang | 2011 | Neural Regeneration Research2011，6，9： | 4 |
| 4 | Detecting Non-Stationarity for Auscultation Signal of Traditional Chinese Medicine显示文摘The information about the nonstationarity of the aus-cultation signal is utilized in this paper to objectively and auto-matically identify healthy people and patients with qi-deficiency or yin-deficiency. In order to characterize the nonstationarity of the sound signal,the nonlinear cross-prediction method is used to extract features from the signal. A feature selection method based on conditional mutual information maximization criterion (CMIM) is implemented to find an optimal feature set. By means of the support vector machine (SVM) classifier,three common states (healthy,qi-deficiency and yin-deficiency) in traditional Chinese medicine are distinguished using the feature set,and a satisfactory classification accuracy of 80% is achieved in the experiment. In conclusion,the analysis based on the nonstationarity of the sound signal provides an alternative and outstanding approach to the objective auscultation of traditional Chinese medicine (TCM). | YAN Jianjun SHEN Qingwei WANG Yiqin LI Fufeng GUO Rui CHEN Chunfeng SHEN Yong | 2011 | Wuhan University Journal of Natural Sciences2011，16，1： | 1 |
| 5 | A novel transgenic mouse model of Chinese CharcotMarie-Tooth disease type 2L显示文摘We previously found that the K141N mutation in heat shock protein B8(HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family.The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene,and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L,and consequently be suitable for use in studies of disease pathogenesis.Transgenic mice overexpressing K141NHSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system.PCR and western blot analysis confirmed integration of the K141NHSPB8 gene and widespread expression in tissues of the transgenic mice.The K141NHSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination,but no obvious sensory disturbance at 6 months of age by behavioral assessment.Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased,but motor nerve conduction velocity remained normal at 6 months of age.Pathological analysis of the sciatic nerve showed reduced myelinated fiber density,notable axonal edema and vacuolar degeneration in K141NHSPB8 transgenic mice,suggesting axonal involvement in the peripheral nerve damage in these animals.These findings indicate that the K141NHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease. | Ruxu Zhang Fufeng Zhang Xiaobo Li Shunxiang Huang Xiaohong Zi Ting Liu Sanmei Liu Xuning Li Kun Xia Qian Pan Beisha Tang | 2014 | Neural Regeneration Research2014，9，4： | 1 |
| 6 | Normalized Acquisi- tion System of the Facial Diagnosis in Traditional Chinese Medi- cine显示文摘 | Fufeng Li Peng Qian Xiaoyan Zheng | 2013 | Applied Mechanics and Materials2013，，： | 1 |
| 7 | Computer - assisted lip diagnosis on traditional Chinese medicine using multi - class support vector machines 显示文摘 | Fufeng Li Changbo Zhao Zheng Xia | 2012 | BMC Complement Ahem Med2012，12，： | 1 |
| 8 | Molecular basis of cross-interactions between Aβ and Tau protofibrils probed by molecular simulations显示文摘Amyloid β-protein(Aβ) and Tau, two common pathogenic proteins associated with Alzheimer’s disease(AD), cross-interact, and thus co-assemble into hybrid aggregates. However, molecular mechanism of the cross-interactions remains unclear. To explore the issue, docking and molecular dynamics(MD) simulations were coupled to study the cross-interactions between Aβ pentamer and Tau pentamer. Four stable hybrid decamer conformations including double layer, single layer, block, and part-in were obtained by protein-protein docking software HADDOCK 2.2. Then, MD simulations were used to explore the molecular mechanism of cross-interactions between Aβ pentamer and Tau pentamer. The results of MD simulations showed that the part-in structure was the most stable among all the above four representative ones. The binding energy between Aβ and Tau was about-759.77 kJ·mol-1in the part-in structure. Moreover, the part-in conformation would undergo conformational transition, which would improve its hydrophobicity and make the structure more compact. This work offers a structural understanding of cross-interactions between Aβ and Tau linked to AD. | Fufeng Liu Luying Jiang Jingcheng Sang Fuping Lu Li Li | 2023 | Chinese Journal of Chemical Engineering2023，55，3： | 0 |
| 9 | Paclitaxel-induced activation of murine peritoneal macrophage in vitro显示文摘Objective:To study the effects of paclitaxel on macrophage activation.Methods:Mouse macrophages were isolated by peritoneal lavage and cultured in RPMI 1640 medium according to the following groups:paclitaxel(5μmol/L) group,IFN-γ(5U/L) group,paclitaxel (5μmol/L) and IFN-γ (5U/L) combination group, and control group(without paclitaxel and IFN-γ).24 hours later,supernatants were collected for nitric oxide(NO) assessment using the Griess reagent, and tumor necrosis factor-α(TNF-α) assessment using the enzyme linked immunosorbent assay.Antibody-dependent cell-mediated cytotoxicity(ADCC) of the macrophages was assessed using the method of hemoglobin-enzyme release assay (Hb-ERA).Results:Paclitaxel induced the production of higher levels of NO(8.86±1.16μmol/L) and TNF-α(120.2±10.2pg/ml),and enhanced the ADCC of macrophages[(20.61±1.13)%].The differences were significant compared with the control group[no NO and TNF-α detected,ADCC (15.37±1.93)%](P<0.01).Paclitaxel and IFN-γ in combination induced the production of higher levels of NO(22.85±0.91μmol/L) and TNF-α(358.6±27.5pg/ml),and enhanced the ADCC of macrophages[(42.49±3.09)%].The differences were significant compared with paclitaxel or IFN-γ[NO 8.09±1.13μmol/L,TNF-α 124.8±9.6pg/ml,ADCC (23.32±2.63)%] alone(P<0.01).Conclusion:These findings indicate that paclitaxel can promote NO and TNF-α production,enhance ADCC of macrophages,and induce macrophage activation.The active effects are more significant with paclitaxel and IFN-γ combination. | Li Zhongxiang Wang Fufeng Qiao Yuhuan | 2004 | 现代妇产科进展2004，13，2： | 0 |
| 10 | Highly Sensitive Functionalized Conducting Copolypyrrole Film for DNA Sensing and Protein-resistant显示文摘以便利用 polypyrrole (PPy ) 的应用在生物传感器和生物电子的衍生物, biomolecules 的不同固定机制到上不同地,进行 PPy 电影的 functionalized 被调查。有 carboxyl 和氨基的组的吡咯和吡咯衍生物被化学聚合的方法与在 Au 表面上自我装配的 -(N-pyrrolyl)-octylthiol 异分子聚合形成共聚物电影的层,即, poly [pyrrole-co-( N-pyrrolyl ) -caproic 酸]( poly ( Py-co-PyCA ))并且 poly [pyrrole-co-( N-pyrrolyl )-hexylamine]( poly ( Py-co-PyHA )),在哪个 carboxyl 组在( Py-co-PyCA ) poly 被激活到酉旨组。基于结构特征, PPy 上的 DNA 分子的固定 / 杂交, poly (Py-co-PyCA ) 并且(Py-co-PyHA ) 被周期的 voltammograms 大小 poly 调查。为不同地 functionalized 共聚物, DNA 的固定机制是各种各样的。在前后,而且, PPy 和它的共聚物的合成电极的电气化学的性质正在被检测牛的浆液白朊(BSA ) 吸附,蛋白质绑定的运动过程被光谱学的表面电浆子回声决定。因为很少 BSA 分子能抛锚到 PPy 和它的共聚物表面上,它建议这种进行的聚合物能作为蛋白质抵抗的材料被使用。 | Zhang,Zhihong Li,Guijuan Yan,Fufeng Zhang,Zhonghou Fang,Shaoming | 2012 | Chinese Journal of Chemistry2012，30，2： | 0 |
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