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| 1 | First Efficient Synthesis of 7-Epi-14-isocyano-isodauc-5-ene from a -(-)-Santonin显示文摘The natural products containing isodaucane skeleton 1 belonged to a rare kind of sesqiterpenes.1 In recent years, investigation on this kind sesquiterpenes have been attracting the interest of chemists, because some isodaucane sesquiterpenes isolated from the medical plants have been shown important bioactivities.2 The main synthetic challenge of isodaucane natural products resided in the introduction of syn-C1-methyl and C8-isopropyl groups. Although some approaches to synthesize isodaucane have been reported to date,3 they needed several steps to construct the cyclopentane unit bearing syn-methyl and isopropyl groups. | LI DeRun | 2001 | Chemical Research in Chinese Universities2001，17，z1： | 0 |
| 2 | 微波电子枪外回路耦合度计算与实验研究显示文摘在热阴极微波电子枪的研制中,为设计微波腔链与波导的耦合孔,应用Derun Li等提出的“能量方法”进行模拟计算。使用MAFIA计算微波电子枪第3腔与外回路馈电波导之间的耦合度,从而设计连接波导与腔链的耦合孔,使两者之间的耦合度满足需要。该方法的计算结果与实验测量值的差别在10%—30%之间,满足实际加工要求。说明其对于驻波加速腔链与外回路耦合的设计计算是相当有效的。 | 边晓浩 陈怀璧 郑曙昕 Derun Li | 2005 | 高能物理与核物理2005，29，11： | 0 |
| 3 | LOM and HOM damping study in a superconducting deflecting cavity for ALS at LBNL显示文摘Superconducting deflecting cavities can be used in synchrotron light source to generate subpico- second X-ray pulses while the impedance of the lower order modes(LOM)and higher order modes(HOM) in the cavity should be kept below an accepted level to avoid beam instability.These modes can be damped by adding waveguide on beam pipe.Detailed simulation of Q in CST Microwave Studio is introduced and experiment results on an aluminum model cavity with damping waveguide are reported to make a comparison. | 施嘉儒 陈怀璧 唐传祥 郑曙昕 Derun Li | 2008 | Chinese Physics C2008，32，3： | 0 |
| 4 | Inspired heat shock protein alleviating prodrug enforces immunogenic photodynamic therapy by eliciting pyroptosis显示文摘Despite immunotherapy involving immune checkpoint inhibitors(ICIs)have revolutionized cancer therapy,the clinical efficacy is limited due to ICI resistance.Pyroptosis is a gasdermin-mediated programmed cell death that enhances responses to ICIs.However,nontargeted elicitation of pyroptosis may induce systemic side effects and toxicity.Therefore,we reasonably design and construct a tumor-specific prodrug that combines the heat shock protein 90 inhibitor tanespimycin(17-AAG)with the photosensitizer chlorin e6(Ce6)to induce pyroptosis,by utilizing the high glutathione level in the tumor microenvironment.The released Ce6 and 17-AAG produce reactive oxygen species by laser triggering,which induces gasdermin E-mediated pyroptosis.Furthermore,17-AAG reduces myeloid-derived suppressor cells and sensitizes tumors to anti-programmed death^(-1)(PD-1)therapy.Thus,our prodrug strategy achieves tumor-targeted pyroptosis to suppress tumor growth,thereby improving the response to anti-PD-1 therapy and extending the survival of 4T1 breast tumor-bearing mice.Consequently,this pyroptosis-based prodrug represents a novel strategy for enforcing immunogenic photodynamic therapy. | Junjie Zhou Xianbin Ma Hao Li Derun Chen Liang Mao Leilei Yang Tian Zhang Wei Qiu Zhigang Xu Zhi-Jun Sun | 2022 | Nano Research2022，15，4： | 0 |
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