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| 1 | Small changes huge impact: the role of thioredoxin 1 in the regulation of apoptosis by S-nitrosylation显示文摘氮的氧化物(没有) 是 apoptosis 的 bioregulator,它有 antiapoptotic 和 proapoptotic 功能。然而,为它的相反的生物效果负责的分子的机制充分没被理解。在蛋白质 S-nitrosylation 的学习的最近的进展可以提供新奇卓见进由号码发信号的 apoptotic 的规定而另外的蛋白质的 S-nitrosylation 例如 caspases 和 Bcl-2 ,禁止 apoptosis ,一些蛋白质的 S-nitrosylation 例如 glyceraldehyde-3-phosphate 脱氢酶和船边交货,刺激 apoptosis ,暗示这translational以后修正的生物功能的复杂性。而且, nitrosylation 和 denitrosylation 能被 thioredoxin 调整 1 (Trx1 ) 系统。研究显示出那 Trx1 任何一个 transnitrosylates,取决于在 Trx1 的不同半胱氨酸残余的氧化还原作用地位或 denitrosylates 特定的蛋白质。S-nitrosylated Trx1 的 Cys73 为它的 transnitrosylating 活动负责而在为它的 denitrosylating 活动的 Trx1 的 Cys32 的免费 thiol。在这 minireview,我们在在 Trx1 和 NO 目标之间的相互作用的理解提供概述,并且在调整 apoptosis 讨论调停 Trx1 的 S-nitrosylation 的角色和特定的蛋白质的 denitrosylation。 | Huili Li Ajun Wan Guoqiang Xu Dequan Ye | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 4 |
| 2 | Characterization of folate-graft-chitosan as a scaffold for nitric oxide release显示文摘 | Ajun Wan Yan Sun Huili Li | 2008 | International Journal of Biological Macromolecules2008，，5： | 1 |
| 3 | Characterization of novel quaternary chitosan derivative nanoparticles loaded with protein显示文摘 | Wan Ajun Sun Yan Li Huili | 2009 | Journal of Applied Polymer Science2009，114，： | 1 |
| 4 | Preparation of aspirin and probueol in combination loaded chitosan nanoparticles and in vitro release study显示文摘 | AJUN W YAN S LI G | 2009 | Carbohydrate Polymers2009，75，4： | 1 |
| 5 | Preparation of aspirin and probucol in combination loaded chitosan nanoparticles and in vitro release study显示文摘 | Wan Ajun Sun Yan Gao Li Li Huili | 2008 | Carbohydrate Polymers2008，，4： | 1 |
| 6 | Characterization of folate-graft chitosan as a scaffold for nitric oxide release 显示文摘 | Wan Ajun Sun Yan Li Huili | 2008 | Inter- national Journal of Biological Macromolecules2008，43，5： | 1 |
| 7 | Preparation of aspilin and probucol in combination loaded chitosan nanoparticles and in vitro release study 显示文摘 | Ajun W Yan S Li G | 2009 | Carbohydrate Polymers2009，75，4： | 1 |
| 8 | Adaption differential evalution algorithm for multiobjective optimization problems显示文摘 | QIAN Weiyi LI Ajun | 2008 | Applied Mathematics and Computation2008，201，： | 1 |
| 9 | Preparation of aspirin and probuco! in combination loaded chitosan nanoparticles and in vitro release study显示文摘 | AJUN W YAN S LI G | 2009 | Carbohydrate Polymers2009，75，4： | 1 |
| 10 | In Situ Monitoring of Transmetallation in Electric Potential-Promoted Oxidative Coupling in a Single-Molecule Junction显示文摘To monitor and investigate chemical reactions in real time and in situ is a long-standing,challenging goal in chemistry.Herein,an electric potential-promoted oxidative coupling reaction of organoboron compounds without the addition of base is reported,and the transmetallation process involved is monitored in real time and in situ with the scanning tunneling microscopy break single-molecule junctions(STMBJ)technique.We found that the electric potential applied determined the transmetallation.At low-bias voltage,the first-step transmetallation process occurred and afforded Au─C-bonded aryl gold intermediates.The electronic properties of organoboron compounds have a strong influence on the transmetallation process,and electron-rich compounds facilitate this transformation.At high-bias voltage,the second-step transmetallation process took place,and the corresponding intermediate(highly reactive diaryl metal complex)was detected with the assistance of Pd(OAc)_(2).Our work demonstrates the applications of STMBJ on in situ monitoring and catalyzing of chemical reactions and provides a new methodology to fabricate singlemolecule devices. | Yunpeng Li Chengxi Zhao Rui Wang Ajun Tang Wenjing Hong Dahui Qu He Tian Hongxiang Li | 2023 | CCS Chemistry2023，5，1： | 0 |
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