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44篇 您的检索式：作者名="LEYBAERT L"

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	题名	作者	年代	出处	被引量
1	TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。	Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊	2018	神经损伤与功能重建2018，13，6：	5
2	ATP-dependent astrocyte-endothelial calcium signaling following mechanical damage to a single astrocyte in astrocyte-endothelial co-cultures显示文摘	Paemeleire K Leybaert L	2000	J Neurotrauma2000，17，4：	1
3	Gap junc-tional communication and connexin 43 expressionin relation to apoptotic cell death survival of granulosa cells显示文摘	Krysko DV Mussche S Leybaert L	2004	J Histochem Cytochem2004，52，：	1
4	Gap junctions and the propagation of cell survival and cell death signals显示文摘	Krysko DV Leybaert L Vandenabeele P	2005	Apoptosis2005，10，3：	1
5	Inositol 1,4,5-trisphosphate receptor function in human oocytes:calcium responses and oocyte activationrelated phenomena induced by photolytic release of InsP3 are blocked by a specific antibody to the type I receptor显示文摘	Goud PT Goud AP Leybaert L	2002	Mol Hum Reprod2002，8，10：	1
6	Gap junctions and the propagation of cell survival and cell death signals 显示文摘	Krysko DV Leybaert L Vandenabeele P	2005	Apoptosis2005，10，3：	1
7	Connexin channels, connexin mimetic peptides and ATP release 显示文摘	Leybaert L Braet K Vandamme W	2003	Cell Commun Adhes2003，10，46：	1
8	A simple and practical method to acquire geometrically correct images with resonant scanning-based line scanning in a custom-built video-rate laser scanning microscope显示文摘	LEYBAERT L de MEYER A MABILDE C	2005	Journal of Microscopy2005，219，3：	1
9	Changes of intracellular free calcium following mechanical injury in a spinal cord slice preparation显示文摘	de Hemptinne A	1996	Exp Brain Res1996，112，：	1
10	The gap junction cellular internet:connexinhemichannels enter the signalling limelight显示文摘	Evans WV Leybaert L	2006	Biochem J2006，397，1：	1
11	The gap junction cellular internet:connexin hemichannels enter the signalling limelight显示文摘	EVANS W H DEVUYST E LEYBAERT L	2006	Biochem J2006，397，1：	1
12	Gap junctional communication and connexin43 expression in relation to apoptotic cell death and survival of granulosa cells显示文摘	Krysko DV Mussche S Leybaert L	2004	Histochem Cytochem2004，52，6：	1
13	First and second messenger role of calcium: survival versus apoptosis in serum-free cultured granulosa explants 显示文摘	Mussche S Leybaert L D'Herde K	2000	Ann NY Acad Sci2000，926，1：	1
14	Gap junctional communication and connexin 43 expression in relation to apoptotic cell death and survival of granulosa cells 显示文摘	Krysko DV Mussche S Leybaert L D' Herde K	2004	Histochem Cytochem2004，52，9：	1
15	Gap junctions and the propagation of cell survival and cell death signals显示文摘	Krysko DV Leybaert L Vandenabeele P	2005	Apoptosis2005，10，：	1
16	The gap junction cellular intemet:connexin hemichannels enter the signaling limelight 显示文摘	Evans WH De Vuyst E Leybaert L	2006	Biochem J2006，397，1：	1
17	The gap junction cellular internet: connexin hemichannels enter the signalling limelight 显示文摘	Evans WH De Vuyst E Leybaert L	2006	Biochem J2006，397，1：	1
18	Gap junctional communication and connexin43 expression in relation to apoptotic cell, death and survival of granulose cells显示文摘	Krysko DV Mussche S Leybaert L	2004	J Histochem Cytochem2004，52，9：	1
19	Gap junctional communication and connexin43 expression in relation to apoptotic cell death and survival of granulosa cells显示文摘	Krysko DV Mussche S Leybaert L	2004	J Histochem Cytochem2004，52，9：	1
20	The gap junction cellular In-ternet :connexin hemichannels enter the signalling limelight 显示文摘	Evans WH De Vuyst E Leybaert L	2006	Biochem J2006，3971，：	1

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