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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Stress Proteins (HSPs): Method of Detection and Their use as an Environmental Biomarker显示文摘 | Lewis S Handy R D | 1999 | Ecotoxicology1999，8，： | 2 |
| 4 | Necessary and sufficient for delayindependent stability of linear autonomous system显示文摘 | LEWIS R W ANDSON B D O | 1980 | IEEE Trans on Automat Contr1980，25，： | 2 |
| 5 | Effect of two opposing changes in photoperiod upon age at first egg and related traits in layer - hybrid pullets 显示文摘 | Lewis P D Perry G C Morris T R | 2003 | Journal of Agricultural Science Cambridge2003，140，： | 1 |
| 6 | A role for the AKT1 potassium channel in plant nutrition显示文摘 | Hirsch R E Lewis B D Spalding E P | 1998 | Science1998，280，： | 1 |
| 7 | Stress Proteins (HSPs):Method of detection and their use as an environmental biomarker 显示文摘 | Lewis S Handy R D | 1999 | Ecotoxicology1999，8，： | 1 |
| 8 | The Effect of Ceramic Fiber Coatings on the Room-Temperature Mechanical Behavior of Ceramic?Fiber Composites显示文摘 | R W Rice J R Spann D Lewis | 1984 | Ceramic Engineering and Science Proceedings1984，5，78： | 1 |
| 9 | A model for predicting the age at sexual maturity for growing pullets of layer strains given a single change in photoperiod 显示文摘 | Lewis P D Morris T R Perry G C | 2002 | Journal of Agricultural Science Cambridge2002，130，： | 1 |
| 10 | Modelling through-soil transport of phosphorus to surface waters from livestock agriculture at the field and catchment scale 显示文摘 | MeGechan M B Lewis D R Hooda P S | 2005 | Science of the Total Environment2005，344，13： | 1 |
| 11 | Web space reconstruction with a M-V flap显示文摘 | LEWIS R C NORDYKE M D DUNCAN K H | 1988 | J Hand Surg Am1988，13，1： | 1 |
| 12 | Effect of constant and of changing photoperiod on plasma LH and FSH concentrations and age at first egg in layer strains of domestic pullets显示文摘 | Lewis P D Perry G C Morris T R | 1998 | Br Poult Sci1998，39，： | 1 |
| 13 | The effect of microbial phytase in a pearl millet-soybean meal diet on apparent digestibility and retention of nutrients,serum mineral concentration,and bone mineral density of nurscry pigs显示文摘 | MURRY A C LEWIS R D AMOS H E | 1997 | J Anim Sci1997，75，： | 1 |
| 14 | Dredging impact on an urbanized Florida bayou, effects on benthos and algal-periphyton显示文摘 | LEWIS M A WEBER D E STANLEY R S | 2001 | Environmental Pollution2001，115，2： | 1 |
| 15 | Modeling of substitutionin SAPO-5 and SAPO-34 molecular sieves 显示文摘 | Sastre G Lewis D W Catlolw C R | 1997 | Journal of Physical Chenistry1997，101，27： | 1 |
| 16 | Enhancement of calcium signalling dynamics and stability by delayed modulation of the plasmamembrane calcium-ATPase in human T cells 显示文摘 | BAUTISTA D M HOTH M LEWIS R S | 2002 | J Physiol2002，541，3： | 1 |
| 17 | Numerical comparison of a deformable discrete element model and an equivalent continuum analysis for the compaction of ductile porous material显示文摘 | Ransing R S Lewis R W | 2001 | Computers and Structures2001，79，： | 1 |
| 18 | Ultrastructural localization of sulfated and unsulfated keratan sulfate in normal and macular cornealdystrophy type Ⅰ 显示文摘 | Lewis D Davies Y Nieduszynski IA Fullwood NJ Lawrence F Ronshek R | 2000 | Glycobiology2000，10，3： | 1 |
| 19 | Factor influencing the distribution of lindane and other hexachlorocyclohexane in the environment显示文摘 | Waller K Vallero D A Lewis R G | 1999 | Environmental Science and Technology1999，33，24： | 1 |
| 20 | A role for the AKT1 potassium channel in plant nutrition 显示文摘 | HIRSCII R E LEWIS B D SPALDING E P el al | 1998 | Science1998，280，5365： | 1 |
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