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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | The use of adjoint equations to solve a variational adjustment problem with advective constrains 显示文摘 | Lewis J M Derber C | 1985 | Tellus1985，37，4： | 2 |
| 3 | Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome显示文摘 | Eswar Krishnan C Kent Kwoh H Ralph Schumacher Lewis Kuller | 2007 | Hypertension2007，，2： | 2 |
| 4 | Breathless cancer cells get fat on glutamine显示文摘 | Dimitrios Anastasiou Lewis C Cantley | 2012 | Cell Research2012，22，3： | 2 |
| 5 | α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation显示文摘尽管为有类型 1 糖尿病的个人的小岛移植被显示了产出优异的血葡萄糖控制,它为长期的控制仍然保持不适当。这是部分,由于小岛损害和压力,那能导致贝它房间损失。过量 IL-1β 的抑制;活动可能最小化小岛损害,因此保存工作。IL-1 受体对手(IL-1Ra ) , IL-1β 的一个内长的禁止者;,保护小岛免受导致 cytokine 的坏死和 apoptosis 的伤害。因此,在 IL-1β 之间的不平衡;并且 IL-1Ra 可能影响到小岛的 allogeneic 和自体免疫的回答的功课。我们的组以前证明传播丝氨酸朊酶禁止者人 alpha-1-antitrypsin (hAAT ) ,以及 immunomodulatory 活动。在现在的学习,我们寻求了决定是否胰腺的小岛 hAAT 的 allograft 保护的活动被 IL-1Ra 调停感应。我们的结果证明 hAAT 在刺激巨噬细胞在 IL-1Ra 表示导致了 2.04 褶层增加并且 hAAT-pre-treated 小岛接枝在 IL-1Ra 抄本层次展出了 4.851 褶层增加,它与中等煽动性的侧面被联系。出人意料地,从 IL-1Ra-knockout 鼠标被孤立并且在 grafting 前与 hAAT 预先对待进野类型的鼠标的小岛在大概从渗入主机房间被导出的 intragraft IL-1Ra 表示产出增加,当主机的 hAAT 处理不在时的虽然。确实, hAAT-pre-treated 小岛产生了能在有教养的巨噬细胞导致 IL-1Ra 生产的 hAAT 免费的调节媒介。最后,我们证明 hAAT 为 p65 支持了不同 phosphorylation 和原子 translocation 模式,为 IL-1Ra 要求的一个关键抄写因素表示。 | Avishag Abecassis Ronen Schuster Galit Shahaf Eyal Ozeri Ross Green David E Ochayon Peleg Rider Eli C Lewis | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 6 | Two feet- two approaches: a component - based model of ecological footprinting 显示文摘 | Simmons C Lewis K Barrett J | 2000 | Ecological Economics2000，32，3： | 1 |
| 7 | Effect of two opposing changes in photoperiod upon age at first egg and related traits in layer - hybrid pullets 显示文摘 | Lewis P D Perry G C Morris T R | 2003 | Journal of Agricultural Science Cambridge2003，140，： | 1 |
| 8 | Robust Adaptive Control of Induction Motors Without Flux Measurment显示文摘 | Kwan C M Lewis F L Yeung K S | 1995 | ACC1995，32，6： | 1 |
| 9 | Drug-induced liver disease in 2006 显示文摘 | Arundel C Lewis JH | 2007 | Curr Opin Gastroenterol2007，23，3： | 1 |
| 10 | Geochemical characteristics of oils from Qaidam,Shanganning and Jianghan basins,China显示文摘 | PHILP R P FAN P LEWIS C A | 1991 | Journal of Southeast Asian Earth Sciences1991，5，3： | 1 |
| 11 | Resonant production of solitons in the RLW equation显示文摘 | LEWIS J C TJON J A | 1979 | Phys Lett A1979，73，： | 1 |
| 12 | Role of HERV-W syneytin-1 in placentation and maintenance of human pregnancy 显示文摘 | NOORALI S ROTAR IC LEWIS C | 2009 | Appl Immunohistochem Mol Morphol2009，17，4： | 1 |
| 13 | Thyrocyles express a function- al toll - like receptor 3 : overexpression can be induced by viral in- fection and reversed by phenylmethimazole and is associated with Hashimoto autoimmune thyroiditis显示文摘 | Harii N Lewis C J Kohn ID | 2005 | Mol Endocrinol2005，19，5： | 1 |
| 14 | Associated and non-associated visco-plasticity and plasticity in soil mechanics显示文摘 | Zienkiewicz O C Humpheson C Lewis R W | 1975 | Geostechnique1975，25，4： | 1 |
| 15 | Identification of urocortin III,an additional member of the corticotrophin-releasing factor (CRF) family with high affinity for the CRF2 receptor显示文摘 | Lewis K Li C Perrin M H | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 16 | Gizard formation and the role of Bapxl显示文摘 | Corinne N Lewis C M Jay C C | 2001 | Develop Biol2001，231，1： | 1 |
| 17 | High basal levels of functional toll- like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papil- lary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration 显示文摘 | McCall KD Harii N Lewis C J | 2007 | Endocrinology2007，148，9： | 1 |
| 18 | A Four-Channel Time-Interleaved ADC With Digital Calibration of Interchannel Timing and Memory Errors显示文摘 | Law C H Hurst P J Lewis S H | 2010 | IEEE J Solid-State Circuits2010，45，10： | 1 |
| 19 | Associated and non-associated visco-plasticity and plasticity in soil mechanics 显示文摘 | Zienkiewicz O C Humpheson C Lewis R W | 1975 | Geotechnique1975，25，4： | 1 |
| 20 | Associ- ated and non-associated viscoplasticity and plasticity in soil mechanics 显示文摘 | Zienkiewicz 0 C Humpheson C Lewis R W | 1975 | Geotechnique1975，25，4： | 1 |
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