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| 1 | Human immunodeficiency virus infection and the liver显示文摘Liver disease in human immunodeficiency virus(HIV)-infected individuals encompasses the spectrum from abnormal liver function tests,liver decompensation,with and without evidence of cirrhosis on biopsy,to non-alcoholic liver disease and its more severe form,non-alcoholic steatohepatitis and hepatocellular cancer.HIV can infect multiple cells in the liver,leading to enhanced intrahepatic apoptosis,activation and fibrosis.HIV can also alter gastro-intestinal tract permeability,leading to increased levels of circulating lipopolysaccharide that may have an impact on liver function.This review focuses on recent changes in the epidemiology,pathogenesis and clinical presentation of liver disease in HIV-infected patients,in the absence of co-infection with hepatitis B virus or hepatitis C virus,with a specific focus on issues relevant to low and middle income countries. | Megan Crane David Iser Sharon R Lewin | 2012 | World Journal of Hepatology2012,4,3: | 5 |
| 2 | Residual renal function in peritoneal dialysis with failed allograft and minimum immunosuppression显示文摘Immunosuppression(IS) is often withdrawn in patients with end stage renal disease secondary to a failed renal allograft, and this can lead to an accelerated loss of residual renal function(RRF). As maintenance of RRF appears to provide a survival benefit to peritoneal dialysis(PD) patients, it is not clear whether this benefit of maintaining RRF in failed allograft patients returning to PD outweigh the risks of maintaining IS. A 49 year-old Caucasian male developed progressive allograft failure nine years after living-donor renal transplantation. Hemodialysis was initiated via tunneled dialysis catheter(TDC) and IS was gradually withdrawn. Two weeksafter IS withdrawal he developed a febrile illness, which necessitate removal of the TDC and conversion to PD. He was maintained on small dose of tacrolimus(1 mg/d) and prednisone(5 mg/d). Currently(1 year later) he is doing exceedingly well on cycler-assisted PD. Residual urine output ranges between 600-1200 m L/d. Total weekly Kt/V achieved 1.82. RRF remained well preserved in this patient with failed renal allograft with minimal immunosuppressive therapy. This strategy will need further study in well-defined cohorts of PD patients with failed allografts and residual RRF to determine efficacy and safety. | Nadear Elmahi éva Csongrádi Kenneth Kokko Jack R Lewin Jamie Davison Tibor Fülp | 2013 | World Journal of Transplantation2013,3,2: | 5 |
| 3 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001,,4: | 3 |
| 4 | Vulvar granular cell tumor显示文摘Granular cell tumors are rare,usually benign,soft tissue neoplasms of neural origin.They occur more often in females than males,the peak age incidence is in the fourth through fifth decades.They can occur anywhere in the body with up to 15% situated in the vulva.The commonest presentation is as an asymptomatic mass.Microscopic findings are usually sufficient,but immunohistochemistry can also be helpful in confirming the diagnosis.The vulvar tumors are benign in 98% of cases with 2% reported as malignant.In this case report we describe a woman with a granular cell tumor confirmed by biopsy who underwent excision of the mass but with focal extension to the resection margin on microscopy.Our recommendation of re-excision was declined.Since it is not uncommon with these tumors to find groups of tumor cells extending beyond the macroscopic limits of growth,we conclude that it is advisable to have margins assessed intraoperatively by frozen section such that further excision can be performed for positive margins.Our patient has been followed for 18 mo without recurrence,should the tumor recur,re-excision,with frozen section control,is indicated.Recurrence rates are reported as 2%-8% with clear margins and 20% with positive margins. | Michel E Rivlin G Rodney Meeks Mohamed A Ghafar Jack R Lewin | 2013 | World Journal of Clinical Cases2013,1,4: | 2 |
| 5 | Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations显示文摘 | HELLER G ZHANG Lin-qi | 2002 | Blood2002,100,6: | 1 |
| 6 | Evaluation of HSV-tk gene therapy in a rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes显示文摘 | Gerolami R Cardoso J Lewin M | | 0,,: | 1 |
| 7 | Model-based Control of Fuel Cells: (1) Regulatory Control显示文摘 | Golbert J Lewin D R | 2004 | J Power Sources2004,135,: | 1 |
| 8 | Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea显示文摘 | Bergenstal R Lewin A Bailey T | 2009 | Curr Med Res Opin2009,25,1: | 1 |
| 9 | The ferric uptake regulator of Pseudomonas aeruginosa has no essential cysteine residues and does not contain a structural zinc ion显示文摘 | Lewin A C Doughty P A Flegg L Moore G R Spiro S | 2002 | Microbiology2002,148,8: | 1 |
| 10 | A elective-titration study ofthe comparative effectiveness of two angiotension Ⅱ receptorblockers, Irbesartan and Losartan显示文摘 | Guthrie R Lewin AJ | 1998 | Clin Ther1998,20,12: | 1 |
| 11 | Identification and Control of Open-loop Unstable Process by Relay Method显示文摘 | Marchetti G Scali C Lewin D R | 2001 | Automatica2001,37,: | 1 |
| 12 | Improved PCA methods for process disturbance and failure identification显示文摘 | WACHS A LEWIN D R | 1999 | AIChE Journal1999,45,8: | 1 |
| 13 | Twice-daily and three-times-daily dosing of a repaglinide/rnetformin fixed-dose combination tablet provide similar glycaemic conlrol显示文摘 | Raskin P Lewin A Reinhardt R | 2009 | Diabetes Obes Metab2009,11,10: | 1 |
| 14 | Polymorphism identification in the ACADM, AT3, ILl0, MyoG and TSHB genes of cattle显示文摘 | Beever J E Fisher S R Lewin H A | 1997 | Animal Genetics1997,28,5: | 1 |
| 15 | Sex differences in neuropsychological functioning among schizophrenic patients 显示文摘 | Lewine RR Walker EF Shurett R | 1996 | Am J Psychiatry1996,153,9: | 1 |
| 16 | Evaluation of HSV-tk gene therapy in a rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes显示文摘 | Cardoso J Lewin M | 2000 | Cancer Res2000,60,4: | 1 |
| 17 | Sessile serrated ade- nomas with low-and high-grade dysplasia and early carcinomas 显示文摘 | Sheridan T B Fenton H Lewin M R | 2006 | Am J Clin Pathol2006,126,4: | 1 |
| 18 | The reaction between hypochlorite and bromides 显示文摘 | FARKAS L LEWIN M BLOCH R | 1949 | J Am Chem Soc1949,71,: | 1 |
| 19 | Free air carbon dioxide enrichment: Development, progress, results显示文摘 | Hendrey G R Lewin K F Nagy J | 1993 | Vegetation1993,,1: | 1 |
| 20 | Sex Differences in Neu-ropsychological Functioning Among Schizophrema显示文摘 | Lewine R R Walker E F Shurett R | 1996 | Am J Psychiatry1996,153,: | 1 |